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64 Results Found

  • Article
  • Open Access
26 Citations
4,280 Views
10 Pages

Epidemics of Crimean-Congo Hemorrhagic Fever (CCHF) in Sudan between 2010 and 2020

  • Ayman Ahmed,
  • Yousif Ali,
  • Bashir Salim,
  • Isabelle Dietrich and
  • Jakob Zinsstag

Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arboviral disease that poses a great threat to global health in the Old World, and it is endemic in Europe, Asia, and Africa, including Sudan. In this retrospective study, we reviewed previous epid...

  • Article
  • Open Access
18 Citations
3,616 Views
8 Pages

The Prevalence and Genetic Variants of the CCHF Virus Circulating among Ticks in the Southern Regions of Kazakhstan

  • Kulyaisan T. Sultankulova,
  • Gaukhar O. Shynybekova,
  • Nurlan S. Kozhabergenov,
  • Nazym N. Mukhami,
  • Olga V. Chervyakova,
  • Yerbol D. Burashev,
  • Kunsulu D. Zakarya,
  • Aziz K. Nakhanov,
  • Kainar B. Barakbayev and
  • Mukhit B. Orynbayev

Crimean–Congo hemorrhagic fever (CCHF) disease cases are registered annually in endemic regions of Kazakhstan. To study the prevalence of various Crimean–Congo hemorrhagic fever virus (CCHFV) genotypes, a total of 694 ticks were collected...

  • Article
  • Open Access
8 Citations
6,159 Views
19 Pages

Ticks on the Run: A Mathematical Model of Crimean-Congo Haemorrhagic Fever (CCHF)—Key Factors for Transmission

  • Suman Bhowmick,
  • Khushal Khan Kasi,
  • Jörn Gethmann,
  • Susanne Fischer,
  • Franz J. Conraths,
  • Igor M. Sokolov and
  • Hartmut H. K. Lentz

Crimean-Congo haemorrhagic fever (CCHF) is a zoonotic disease caused by the Crimean-Congo hemorrhagic fever virus (CCHFV). Ticks of the genus Hyalomma are the main vectors and represent a reservoir for the virus. CCHF is maintained in nature in an en...

  • Case Report
  • Open Access
2 Citations
1,613 Views
6 Pages

Crimean–Congo Hemorrhagic Fever Mimicking HELLP Syndrome in a Pregnant Woman and Her Infant in Kosovo: A Case Report

  • Lindita Ajazaj-Berisha,
  • Bahrije Halili,
  • Vera Ndrejaj,
  • Kurtesh Sherifi,
  • Xhevat Jakupi,
  • Simone Priesnitz,
  • Christoph J. Hemmer,
  • Salih Ahmeti and
  • Petra Emmerich

26 January 2025

Crimean–Congo hemorrhagic fever (CCHF) is fatal in 10 to 40% of cases. It is caused by CCHF virus (CCHFV). Symptoms include fever, headache, myalgia, and often hemorrhage and other complications. This report shows that CCHF may resemble HELLP s...

  • Article
  • Open Access
14 Citations
2,793 Views
6 Pages

Detection of Crimean-Congo Hemorrhagic Fever Virus Antibodies in Cattle in Plateau State, Nigeria

  • Asabe A. Dzikwi-Emennaa,
  • Clement Meseko,
  • Paulinus Emennaa,
  • Adedeji J. Adeyinka,
  • Andrew M. Adamu and
  • Oyelola A. Adegboye

24 November 2022

Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral hemorrhagic disease with global clinical significance. Certain species of ticks are vectors of CCHF, which can be transmitted from animals to humans and humans to humans by direct exposur...

  • Article
  • Open Access
31 Citations
4,887 Views
19 Pages

Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome

  • Miša Korva,
  • Katarina Resman Rus,
  • Miša Pavletič,
  • Ana Saksida,
  • Nataša Knap,
  • Mateja Jelovšek,
  • Katja Strašek Smrdel,
  • Xhevat Jakupi,
  • Isme Humolli and
  • Tatjana Avšič-Županc
  • + 2 authors

26 July 2019

Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fe...

  • Article
  • Open Access
16 Citations
4,065 Views
14 Pages

17 September 2023

Crimean–Congo haemorrhagic fever (CCHF) is considered to be spreading across the globe, with many countries reporting new human CCHF cases in recent decades including Georgia, Türkiye, Albania, and, most recently, Spain. We update a human...

  • Systematic Review
  • Open Access
10 Citations
4,021 Views
37 Pages

Seroprevalence of Crimean Congo Hemorrhagic Fever Virus in Occupational Settings: Systematic Review and Meta-Analysis

  • Matteo Riccò,
  • Antonio Baldassarre,
  • Silvia Corrado,
  • Marco Bottazzoli and
  • Federico Marchesi

Crimean Congo Hemorrhagic Fever (CCHF) Virus can cause a serious human disease, with the case fatality ratio previously estimated to be 30–40%. Our study summarized seroprevalence data from occupational settings, focusing on the following occup...

  • Article
  • Open Access
7 Citations
3,369 Views
13 Pages

Hyalomma spp. in Austria—The Tick, the Climate, the Diseases and the Risk for Humans and Animals

  • Georg Gerhard Duscher,
  • Stefan Kienberger,
  • Klaus Haslinger,
  • Barbara Holzer,
  • Irene Zimpernik,
  • Reinhard Fuchs,
  • Michael Schwarz,
  • Peter Hufnagl,
  • Peter Schiefer and
  • Friedrich Schmoll

Recently, ticks of Hyalomma spp. have been found more often in areas previously lacking this tick species. Due to their important role as a vector of different diseases, such as Crimean-Congo-hemorrhagic fever (CCHF), the occurrence and potential spr...

  • Review
  • Open Access
76 Citations
11,518 Views
19 Pages

Epidemiological Aspects of Crimean-Congo Hemorrhagic Fever in Western Europe: What about the Future?

  • Aránzazu Portillo,
  • Ana M. Palomar,
  • Paula Santibáñez and
  • José A. Oteo

Crimean-Congo hemorrhagic fever virus (CCHFV) is an arthropod-borne virus (arbovirus), mainly transmitted by ticks, belonging to the genus Orthonairovirus (family Nairoviridae, order Bunyavirales). CCHFV causes a potentially severe, or even fatal, hu...

  • Article
  • Open Access
2 Citations
2,461 Views
10 Pages

9 October 2023

Background and Objectives: Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonotic infection, which is seen over a wide geographic area. The mortality rate is in inverse proportion to the ability of patients to access healthcare services. Therefor...

  • Article
  • Open Access
9 Citations
2,355 Views
10 Pages

First Broad-Range Serological Survey of Crimean–Congo Hemorrhagic Fever among Hungarian Livestock

  • Nóra Deézsi-Magyar,
  • Béla Dénes,
  • Bereniké Novák,
  • Gyula Zsidei,
  • Dániel Déri,
  • Judit Henczkó,
  • Bernadett Pályi and
  • Zoltán Kis

29 May 2024

(1) Background: Crimean–Congo hemorrhagic fever (CCHF) is an emerging tick-borne disease endemic in Africa, Asia, the Middle East, and the Balkan and Mediterranean regions of Europe. Although no human CCHF cases have been reported, based on vec...

  • Article
  • Open Access
4 Citations
3,837 Views
13 Pages

Emergence of Crimean–Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022

  • Ousseynou Sene,
  • Samba Niang Sagne,
  • Déthié Ngom,
  • Moussa Moise Diagne,
  • Aminata Badji,
  • Aliou Khoulé,
  • El Hadji Ndiaye,
  • Safietou Sankhe,
  • Cheikh Loucoubar and
  • Gamou Fall
  • + 13 authors

19 February 2024

Crimean–Congo hemorrhagic fever (CCHF), the most widespread tick-borne viral human infection, poses a threat to global health. In this study, clinical samples collected through national surveillance systems were screened for acute CCHF virus (C...

  • Article
  • Open Access
17 Citations
3,064 Views
12 Pages

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

  • Moufid Mhamadi,
  • Aminata Badji,
  • Idrissa Dieng,
  • Alioune Gaye,
  • El Hadji Ndiaye,
  • Mignane Ndiaye,
  • Moundhir Mhamadi,
  • Cheikh Talibouya Touré,
  • Mouhamed Rassoul Mbaye and
  • Oumar Faye
  • + 15 authors

Crimean–Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960. Bordering Mauritania in northeastern Senegal, Agnam is an arid area in the region of Mat...

  • Review
  • Open Access
38 Citations
11,190 Views
30 Pages

Systematic Review of Ticks and Tick-Borne Pathogens of Small Ruminants in Pakistan

  • Abdul Ghafar,
  • Tariq Abbas,
  • Abdul Rehman,
  • Zia-ud-Din Sandhu,
  • Alejandro Cabezas-Cruz and
  • Abdul Jabbar

11 November 2020

Ticks and tick-borne diseases (TTBDis) are a major constraint to the health and production of small ruminants in Pakistan. Despite being the subject of intermittent studies over the past few decades, comprehensive information on the epidemiology and...

  • Article
  • Open Access
17 Citations
5,943 Views
15 Pages

The Crimean-Congo Hemorrhagic Fever Virus NSm Protein Is Dispensable for Growth In Vitro and Disease in Ifnar-/- Mice

  • Stephen R. Welch,
  • Florine E. M. Scholte,
  • Jessica R. Spengler,
  • Jana M. Ritter,
  • JoAnn D. Coleman-McCray,
  • Jessica R. Harmon,
  • Stuart T. Nichol,
  • Sherif R. Zaki,
  • Christina F. Spiropoulou and
  • Eric Bergeron

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tri-segmented, tick-borne nairovirus that causes disease of ranging severity in humans. The CCHFV M segment encodes a complex glycoprotein precursor (GPC) that undergoes extensive endoproteolytic cle...

  • Review
  • Open Access
97 Citations
13,604 Views
25 Pages

Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe

  • Nariman Shahhosseini,
  • Gary Wong,
  • George Babuadze,
  • Jeremy V. Camp,
  • Onder Ergonul,
  • Gary P. Kobinger,
  • Sadegh Chinikar and
  • Norbert Nowotny

The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease tha...

  • Communication
  • Open Access
45 Citations
10,385 Views
8 Pages

The First Outbreak of Dengue Fever in Greater Darfur, Western Sudan

  • Ayman Ahmed,
  • Adel Elduma,
  • Babiker Magboul,
  • Tarig Higazi and
  • Yousif Ali

Dengue virus (DENV) is an arthropod-borne virus (arbovirus) transmitted by the Aedes mosquitoes, mainly Aedes aegypti. Dengue fever is a rapidly growing disease with expanding geographical distribution worldwide. We investigated a high number of non-...

  • Article
  • Open Access
4 Citations
1,823 Views
8 Pages

Background and objectives: In this study, we compare portal vein Doppler ultrasound (US) findings between patients with Crimean–Congo hemorrhagic fever (CCHF) and healthy persons and investigate the practicability of these findings in the predi...

  • Article
  • Open Access
1 Citations
1,385 Views
17 Pages

14 August 2025

Crimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an...

  • Article
  • Open Access
2 Citations
2,852 Views
11 Pages

Large-Scale Serological Survey of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Small Ruminants in Senegal

  • Marie Cicille Ba Gahn,
  • Gorgui Diouf,
  • Ndjibouyé Cissé,
  • Mamadou Ciss,
  • Marion Bordier,
  • Mbengué Ndiaye,
  • Mame Thierno Bakhoum,
  • Mamadou Lamine Djiba,
  • Corrie Brown and
  • Modou Moustapha Lo
  • + 2 authors

15 August 2024

Crimean-Congo hemorrhagic fever (CCHF) and Rift Valley fever (RVF) are among the list of emerging zoonotic diseases that require special attention and priority. RVF is one of the six priority diseases selected by the Senegalese government. Repeated e...

  • Article
  • Open Access
3 Citations
2,343 Views
19 Pages

Increased Expression of Proinflammatory Genes in Peripheral Blood Cells Is Associated with Cardiac Cachexia in Patients with Heart Failure with Reduced Ejection Fraction

  • Anja Sandek,
  • Christoph Gertler,
  • Miroslava Valentova,
  • Nadja Jauert,
  • Manuel Wallbach,
  • Wolfram Doehner,
  • Stephan von Haehling,
  • Stefan D. Anker,
  • Jens Fielitz and
  • Hans-Dieter Volk

27 January 2024

Background: Cardiac cachexia (CC) in chronic heart failure with reduced ejection fraction (HFrEF) is characterized by catabolism and inflammation predicting poor prognosis. Levels of responsible transcription factors like signal transducer and activa...

  • Article
  • Open Access
14 Citations
4,351 Views
21 Pages

A Novel RT-LAMP for the Detection of Different Genotypes of Crimean–Congo Haemorrhagic Fever Virus in Patients from Spain

  • Begoña Febrer-Sendra,
  • Pedro Fernández-Soto,
  • Juan García-Bernalt Diego,
  • Beatriz Crego-Vicente,
  • Anabel Negredo,
  • Juan Luis Muñor-Bellido,
  • Moncef Belhassen-García,
  • María Paz Sánchez-Seco and
  • Antonio Muro

Crimean–Congo haemorrhagic fever (CCHF) is a potentially lethal tick-borne viral disease with a wide distribution. In Spain, 12 human cases of CCHF have been confirmed, with four deaths. The diagnosis of CCHF is hampered by the nonspecific symp...

  • Article
  • Open Access
1,294 Views
16 Pages

Multicriteria Decision Analysis as a Tool for Assessing Vector-Borne Diseases Risk: The Case of Crimean–Congo Hemorrhagic Fever in Türkiye

  • Alessia Milano,
  • Alan Juache,
  • Sarah Houben,
  • Maria Grazia Dente,
  • Claudia Robbiati,
  • Silvia Declich,
  • Ruben Danielyan,
  • Aykut Ozkul,
  • Ilke Karayel-Hacıoglu and
  • Cedric Marsboom
  • + 2 authors

Understanding the risk factors for vector-borne diseases, such as Crimean–Congo hemorrhagic fever (CCHF), is critical for effective public health strategies. This study aims to identify and map the environmental and climatic determinants influe...

  • Review
  • Open Access
6 Citations
3,199 Views
19 Pages

Arthropod-Borne Viruses in Mauritania: A Literature Review

  • Abdallahi El Ghassem,
  • Bedia Abdoullah,
  • Jemila Deida,
  • Mohamed Aly Ould Lemrabott,
  • Mohamed Ouldabdallahi Moukah,
  • Mohamed Salem Ould Ahmedou Salem,
  • Sébastien Briolant,
  • Leonardo K. Basco,
  • Khyarhoum Ould Brahim and
  • Ali Ould Mohamed Salem Boukhary

20 November 2023

During the past four decades, recurrent outbreaks of various arthropod-borne viruses have been reported in Mauritania. This review aims to consolidate the current knowledge on the epidemiology of the major arboviruses circulating in Mauritania. Onlin...

  • Article
  • Open Access
3 Citations
1,716 Views
12 Pages

Prognostic Value of Ratios of Inflammatory Markers in the Prognosis of Crimean–Congo Hemorrhagic Fever

  • Mürşit Hasbek,
  • Yasemin Çakır Kıymaz,
  • Seyit Ali Büyüktuna and
  • Hayrettin Yavuz

Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease, causing clinical presentations ranging from asymptomatic infection to fatal viral hemorrhagic fever. Throughout the course of CCHF, the levels of certain biomarkers, such...

  • Article
  • Open Access
765 Views
9 Pages

Background: Crimean–Congo hemorrhagic fever (CCHF) is a severe zoonotic viral infection with high mortality rates. This study aimed to examine the prognostic value of new-generation inflammatory markers—CRP/albumin ratio (CAR), D-dimer/al...

  • Article
  • Open Access
3 Citations
1,962 Views
11 Pages

Seroprevalence and Risk Factors of Crimean–Congo Hemorrhagic Fever Exposure in Wild and Domestic Animals in Benin

  • Roland Eric Yessinou,
  • Souaïbou Farougou,
  • James Olukayode Olopade,
  • Daniel Oladimeji Oluwayelu,
  • Anise Happi,
  • Christian Happi and
  • Martin Groschup

8 March 2025

Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease prevalent in Africa. While infection is asymptomatic in animals, it can cause severe illness with hemorrhagic manifestations and high mortality rates in humans. This...

  • Article
  • Open Access
15 Citations
2,789 Views
13 Pages

13 September 2023

Crimean–Congo hemorrhagic fever (CCHF) typically spreads through ticks and is categorized as a viral hemorrhagic fever. CCHF is a fatal endemic disease in Iraq, and it has been reported sporadically since its first report in 1979. Recent outbre...

  • Article
  • Open Access
1 Citations
1,545 Views
12 Pages

Molecular and Clinical Characterization of Crimean–Congo Hemorrhagic Fever in Bulgaria, 2015–2024

  • Kim Ngoc,
  • Ivan Stoikov,
  • Ivelina Trifonova,
  • Elitsa Panayotova,
  • Evgenia Taseva,
  • Iva Trifonova and
  • Iva Christova

Crimean–Congo hemorrhagic fever (CCHF) is a zoonotic viral disease endemic to parts of Africa, Asia and southeastern Europe. Bulgaria is one of the few European countries with the consistent annual reporting of human CCHF cases. This study prov...

  • Article
  • Open Access
17 Citations
4,451 Views
14 Pages

Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever in Cattle of Smallholder Farmers in Central Malawi

  • Marvin Collen Phonera,
  • Martin Chitolongo Simuunza,
  • Henson Kainga,
  • Joseph Ndebe,
  • Mwelwa Chembensofu,
  • Elisha Chatanga,
  • Setiala Kanyanda,
  • Katendi Changula,
  • Walter Muleya and
  • Edgar Simulundu
  • + 6 authors

10 December 2021

Crimean-Congo hemorrhagic fever virus (CCHFV) is endemic in Africa, Asia, and Eastern Europe where it circulates among animals and ticks causing sporadic outbreaks in humans. Although CCHF is endemic in sub-Saharan Africa, epidemiological information...

  • Communication
  • Open Access
2 Citations
2,137 Views
7 Pages

Serological Evidence of Crimean–Congo Haemorrhagic Fever in Livestock in the Omaheke Region of Namibia

  • Alaster Samkange,
  • Pricilla Mbiri,
  • Ophelia Chuma Matomola,
  • Georgina Zaire,
  • Anna Homateni,
  • Elifas Junias,
  • Israel Kaatura,
  • Siegfried Khaiseb,
  • Simson Ekandjo and
  • Simbarashe Chitanga
  • + 9 authors

This research examined the positivity ratio of Crimean–Congo haemorrhagic fever (CCHF) antibodies in cattle and sheep within Namibia’s Omaheke region after a human disease outbreak in the same geographical area. A total of 200 samples (10...

  • Review
  • Open Access
35 Citations
5,607 Views
10 Pages

22 June 2021

Crimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality. CCHFV is transmitted to humans through tick bites or direct contact with patients...

  • Communication
  • Open Access
11 Citations
4,029 Views
16 Pages

16 December 2021

Crimean–Congo hemorrhagic fever virus (CCHFV) infrequently causes hemorrhagic fever in humans with a case fatality rate of 30%. Currently, there is neither an internationally approved antiviral drug nor a vaccine against the virus. A replicon b...

  • Article
  • Open Access
3 Citations
1,279 Views
5 Pages

30 August 2013

Background and Objective. A tick bite has been an emergency of increased importance in recent years since it can cause a progressive, fatal disease such as Crimean-Congo hemorrhagic fever (CCHF). This issue should be considered by physicians working...

  • Article
  • Open Access
20 Citations
4,373 Views
17 Pages

T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice

  • David W. Hawman,
  • Kimberly Meade-White,
  • Shanna Leventhal,
  • Aaron Carmody,
  • Elaine Haddock,
  • Kim Hasenkrug and
  • Heinz Feldmann

Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can ra...

  • Article
  • Open Access
10 Citations
3,016 Views
14 Pages

Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever

  • Neda Baseri,
  • Mostafa Salehi-Vaziri,
  • Ehsan Mostafavi,
  • Fahimeh Bagheri Amiri,
  • Mina Latifian,
  • John Stenos and
  • Saber Esmaeili

26 August 2022

Rickettsia conorii is the causative agent of Mediterranean spotted fever (MSF). Misdiagnosis of MSF may occur with febrile syndromes associated with rash and thrombocytopenia, such as Crimean-Congo hemorrhagic fever (CCHF). This study aimed to determ...

  • Communication
  • Open Access
11 Citations
4,552 Views
10 Pages

Seroepidemiology of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in Cattle across Three Livestock Pastoral Regions in Kenya

  • Isabel Blanco-Penedo,
  • Vincent Obanda,
  • Edward Kingori,
  • Bernard Agwanda,
  • Clas Ahlm and
  • Olivia Wesula Lwande

6 August 2021

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease, endemic in Africa, with a high case fatality rate. There is no efficient treatment or licensed vaccine. This study aimed to determine the prevalence of CCHFV in cattle in extens...

  • Review
  • Open Access
68 Citations
7,223 Views
27 Pages

Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease

  • Aura R. Garrison,
  • Darci R. Smith and
  • Joseph W. Golden

28 June 2019

Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. CCHFV is also an emerging virus, with recent outbreaks in Western Europe. CCHFV can infect a large number of wild and...

  • Article
  • Open Access
1,487 Views
17 Pages

Identification of Hyalomma Ticks on Migratory Birds in Poland During the 2023 and 2024 Spring Seasons

  • Klaudia Bylińska,
  • Jan Rapczyński,
  • Paweł Górski,
  • Oliwia Obuch-Woszczatyńska,
  • Damian Pietrzak,
  • Karol Korzekwa,
  • Małgorzata Krzyżowska and
  • Piotr Bąska

19 August 2025

Ticks from the Hyalomma genus have recently garnered public attention in countries in Northern and Central Europe, as they are transported by migratory birds and might have established stable populations due to climate warming. The main threat associ...

  • Article
  • Open Access
1,606 Views
13 Pages

28 December 2024

Crimean–Congo hemorrhagic fever (CCHF) is a serious tick-borne disease with a wide geographical distribution. Classified as a level 4 biosecurity risk pathogen, CCHF can be transmitted cross-species due to its aerosol infectivity and ability to...

  • Article
  • Open Access
14 Citations
3,138 Views
20 Pages

GEM-PA-Based Subunit Vaccines of Crimean Congo Hemorrhagic Fever Induces Systemic Immune Responses in Mice

  • Qi Wang,
  • Shen Wang,
  • Zhikang Shi,
  • Zhengrong Li,
  • Yongkun Zhao,
  • Na Feng,
  • Jinhao Bi,
  • Cuicui Jiao,
  • Entao Li and
  • Xianzhu Xia
  • + 6 authors

28 July 2022

The Crimean Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne bunyavirus of the Narovirus genus, which is the causative agent of Crimean Congo Hemorrhagic Fever (CCHF). CCHF is endemic in Africa, the Middle East, Eastern Europe and Asia, with a h...

  • Review
  • Open Access
16 Citations
6,996 Views
29 Pages

19 August 2023

Crimean–Congo hemorrhagic fever virus (CCHFV), a member of the Nairoviridae family and Bunyavirales order, is transmitted to humans via tick bites or contact with the blood of infected animals. It can cause severe symptoms, including hemorrhagi...

  • Article
  • Open Access
15 Citations
3,727 Views
11 Pages

29 August 2022

Crimean-Congo hemorrhagic fever virus (CCHFV) is a zoonotic, tick-borne pathogen that is endemic to some parts of Europe, Africa, and Asia. The disease causes fever and hemorrhagic manifestations in humans but not in animals. Domestic and wild animal...

  • Article
  • Open Access
16 Citations
3,781 Views
17 Pages

Transmission Dynamics of Crimean–Congo Haemorrhagic Fever Virus (CCHFV): Evidence of Circulation in Humans, Livestock, and Rodents in Diverse Ecologies in Kenya

  • Dorcus C. A. Omoga,
  • David P. Tchouassi,
  • Marietjie Venter,
  • Edwin O. Ogola,
  • Josephine Osalla,
  • Anne Kopp,
  • Inga Slothouwer,
  • Baldwyn Torto,
  • Sandra Junglen and
  • Rosemary Sang

7 September 2023

Crimean–Congo haemorrhagic fever virus (CCHFV) is the causative agent of CCHF, a fatal viral haemorrhagic fever disease in humans. The maintenance of CCHFV in the ecosystem remains poorly understood. Certain tick species are considered as vecto...

  • Communication
  • Open Access
2 Citations
2,334 Views
8 Pages

Identification, Characterization, and Homology Analysis of a Novel Strain of the Crimean–Congo Hemorrhagic Fever Virus from Yunnan, China

  • Jiale Wang,
  • Taif Shah,
  • Jiuxuan Zhou,
  • Xinhua Long,
  • Yixuan Wang,
  • Jie Chen,
  • Mingfei Shi,
  • Zahir Shah,
  • Binghui Wang and
  • Xueshan Xia

Wildlife serve as potential microbial reservoirs, accounting for approximately 70% of emerging infectious diseases. Crimean–Congo hemorrhagic fever virus (CCHFV), which causes Crimean–Congo hemorrhagic fever (CCHF) in humans, is a highly pathogenic t...

  • Abstract
  • Open Access
1,888 Views
2 Pages

The Persistent Infection of Tick Cells by Hazara orthonairovirus Is Mediated by Virus-Derived DNA Forms

  • Maria Vittoria Salvati,
  • Claudia Del Vecchio,
  • Lesley Bell-Sakyi,
  • Cristina Parolin,
  • Arianna Calistri,
  • Giorgio Palù,
  • Ali Mirazimi and
  • Cristiano Salata

Introduction: Crimean–Congo hemorrhagic fever (CCHF) is a severe disease of humans caused by CCHF orthonairovirus (CCHFV), a class 4 pathogen. Hyalomma ticks are the viral reservoir, and they represent the main vector. CCHFV can be transmitted to its...

  • Feature Paper
  • Review
  • Open Access
52 Citations
8,591 Views
13 Pages

Recent Developments in C–H Activation for Materials Science in the Center for Selective C–H Activation

  • Junxiang Zhang,
  • Lauren J. Kang,
  • Timothy C. Parker,
  • Simon B. Blakey,
  • Christine K. Luscombe and
  • Seth R. Marder

Organic electronics is a rapidly growing field driven in large part by the synthesis of π-conjugated molecules and polymers. Traditional aryl cross-coupling reactions such as the Stille and Suzuki have been used extensively in the synthesis of &pi...

  • Review
  • Open Access
1 Citations
3,530 Views
21 Pages

The Expanding Threat of Crimean-Congo Haemorrhagic Fever Virus: Role of Migratory Birds and Climate Change as Drivers of Hyalomma spp. Dispersal in Europe

  • Melissa Alves Rodrigues,
  • Paulina Lesiczka,
  • Maria da Conceição Fontes,
  • Luís Cardoso and
  • Ana Cláudia Coelho

16 June 2025

Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is an emerging zoonotic pathogen with a high case fatality risk. Its primary vectors, Hyalomma spp. ticks, are expanding their geographic range, raising concerns about the increasing risk of Crimean-Cong...

  • Article
  • Open Access
8 Citations
1,872 Views
14 Pages

The objective of this paper is to investigate the 3D non-linearly thermally radiated flow of a Jeffrey nanofluid towards a stretchy surface with the Cattaneo–Christov heat flux (CCHF) model in the presence of a convective boundary condition.The...

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