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T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice

1
Laboratory of Virology, NIAID/NIH, Hamilton, MT 59840, USA
2
Research Technologies Branch, NIAID/NIH, Hamilton, MT 59840, USA
3
Laboratory of Persistent Viral Diseases, NIAID/NIH, Hamilton, MT 59840, USA
*
Authors to whom correspondence should be addressed.
Microorganisms 2021, 9(2), 279; https://doi.org/10.3390/microorganisms9020279
Received: 22 December 2020 / Revised: 25 January 2021 / Accepted: 26 January 2021 / Published: 29 January 2021
(This article belongs to the Section Molecular Microbiology and Immunology)
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. Case fatality rates can be as high as 30%. An important gap in our understanding of CCHF are the host immune responses necessary to control the infection. A better understanding of these responses is needed to direct therapeutic strategies to limit the often-severe morbidity and mortality seen in humans. In this report, we have utilized a mouse model in which mice develop severe disease but ultimately recover. T-cells were robustly activated, differentiated to produce antiviral cytokines, and were critical for survival following CCHFV infection. We further identified a key role for interferon gamma (IFNγ) in survival following CCHFV infection. These results significantly improve our understanding of the host adaptive immune response to severe CCHFV infection. View Full-Text
Keywords: Crimean-Congo hemorrhagic fever; CCHFV; T-cells; mouse model; IFNγ Crimean-Congo hemorrhagic fever; CCHFV; T-cells; mouse model; IFNγ
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MDPI and ACS Style

Hawman, D.W.; Meade-White, K.; Leventhal, S.; Carmody, A.; Haddock, E.; Hasenkrug, K.; Feldmann, H. T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice. Microorganisms 2021, 9, 279. https://doi.org/10.3390/microorganisms9020279

AMA Style

Hawman DW, Meade-White K, Leventhal S, Carmody A, Haddock E, Hasenkrug K, Feldmann H. T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice. Microorganisms. 2021; 9(2):279. https://doi.org/10.3390/microorganisms9020279

Chicago/Turabian Style

Hawman, David W., Kimberly Meade-White, Shanna Leventhal, Aaron Carmody, Elaine Haddock, Kim Hasenkrug, and Heinz Feldmann. 2021. "T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice" Microorganisms 9, no. 2: 279. https://doi.org/10.3390/microorganisms9020279

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