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Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

Department of Pharmacology and Institute of Neuroscience, Faculty of Medicine, University of Granada (Avenida de Madrid 11, 18012 Granada, Spain) and Biomedical Research Center, University of Granada, Parque Tecnológico de Ciencias de la Salud, 18100 Armilla, Granada, Spain
Authors to whom correspondence should be addressed.
Mar. Drugs 2012, 10(2), 281-305;
Received: 30 December 2011 / Revised: 19 January 2012 / Accepted: 19 January 2012 / Published: 31 January 2012
(This article belongs to the Special Issue Tetrodotoxin 2011)
Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs). VGSCs play a critical role in neuronal function under both physiological and pathological conditions. TTX has been extensively used to functionally characterize VGSCs, which can be classified as TTX-sensitive or TTX-resistant channels according to their sensitivity to this toxin. Alterations in the expression and/or function of some specific TTX-sensitive VGSCs have been implicated in a number of chronic pain conditions. The administration of TTX at doses below those that interfere with the generation and conduction of action potentials in normal (non-injured) nerves has been used in humans and experimental animals under different pain conditions. These data indicate a role for TTX as a potential therapeutic agent for pain. This review focuses on the preclinical and clinical evidence supporting a potential analgesic role for TTX. In addition, the contribution of specific TTX-sensitive VGSCs to pain is reviewed. View Full-Text
Keywords: tetrodotoxin; TTX; TTX-sensitive voltage-gated sodium channels; pain; neuropathic pain tetrodotoxin; TTX; TTX-sensitive voltage-gated sodium channels; pain; neuropathic pain
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MDPI and ACS Style

Nieto, F.R.; Cobos, E.J.; Tejada, M.Á.; Sánchez-Fernández, C.; González-Cano, R.; Cendán, C.M. Tetrodotoxin (TTX) as a Therapeutic Agent for Pain. Mar. Drugs 2012, 10, 281-305.

AMA Style

Nieto FR, Cobos EJ, Tejada MÁ, Sánchez-Fernández C, González-Cano R, Cendán CM. Tetrodotoxin (TTX) as a Therapeutic Agent for Pain. Marine Drugs. 2012; 10(2):281-305.

Chicago/Turabian Style

Nieto, Francisco Rafael, Enrique José Cobos, Miguel Ángel Tejada, Cristina Sánchez-Fernández, Rafael González-Cano, and Cruz Miguel Cendán. 2012. "Tetrodotoxin (TTX) as a Therapeutic Agent for Pain" Marine Drugs 10, no. 2: 281-305.

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