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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management and Personalized Treatment in Digestive Surgery

edited by

Bogdan Severus Gaspar

submission deadline 25 Nov 2025 | Viewed by 339 | Submission Open

Keywords: digestive disease; digestive cancers; gastrointestinal surgery; stomach; pancreas; liver

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Spine Surgery: Updates and Challenges

edited by Mark James Lambrechts

submission deadline 25 Nov 2025 | Viewed by 141 | Submission Open

Keywords: spine; orthopedic surgery; neurosurgery; precision; endoscopic spine; artificial disc replacement; spinal deformity; patient-specific alignment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Head and Neck Disease: Personalized Approaches to Screening and Diagnosis

edited by Heejin Kim

submission deadline 25 Nov 2025 | Viewed by 92 | Submission Open

Keywords: otolaryngology; head and neck; rhinosinusitis; thyroidectomy; tonsillectomy; personalized; screening; diagnosis

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Towards Precision Anesthesia and Pain Management

edited by

Giustino Varrassi

, Joseph V. Pergolizzi and Filomena Puntillo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 11515 | Submission Open

Keywords: precision medicine; anesthesia; pain medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Computer-Assisted Diagnosis and Personalized Treatment of Fracture

edited by Juan Jiménez-Delgado

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4218 | Submission Open

Keywords: fracture diagnosis; computer-assisted simulation; artificial intelligence in orthopedics; medical imaging advances; personalized fracture treatment; computational fracture analysis; surgical planning tools; virtual reality in orthopedics; forensic analysis of fractures; multiscale modeling of bone

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

New Insights into Personalized Medicine for Anesthesia and Pain

edited by

Hyun Kang

and Guen Joo Choi

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3310 | Submission Open

Keywords: new insights; personalized medicine; anesthesia; pain management; perioperative analgesia; airway management; perioperative nausea; interventional pain care; critical care; minimally invasive surgery/robotic surgery; mechanical ventilation; chronic pain; acute pain; lumbar/cervical/thoracic/spinal pain; musculoskeletal pain

(This special issue belongs to the Section Personalized Medical Care)

Clinical Advances and Innovations in Reconstructive and Plastic Surgery

edited by Laura Răducu

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3185 | Submission Open

Keywords: plastic surgery; breast reconstruction; robotics; microsurgery; burns injury

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Role of Genetic Tools in Diagnosis and Personalized Treatment for Neurological Diseases

edited by

Federica Scalia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2152 | Submission Open

Keywords: neurological disorders; molecular modeling; bioinformatics; genetic tools; genetic variants; omic technologies; DNA sequencing; newborn screening; therapeutic procedure; mechanism of action

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Epigenetics in Precision Medicine: From Mechanism to Therapy

edited by

Andrea Latini

and

Valerio Caputo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1562 | Submission Open

Keywords: epigenetics; precision medicine; methylation; histone modifications; non-coding RNA

(This special issue belongs to the Section Epigenetic Therapy)

Personalized Medicine in Gastrointestinal Surgical Oncology

edited by

Dae Hoon Kim

and Myoung-Won Son

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1281 | Submission Open

Keywords: personalized medicine; gastrointestinal surgical oncology; laparoscopic surgery; robotic surgery; AI in surgery; multimodal treatment; clinical trials; oncological outcomes

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Radiation Therapy for Cancers: Current Status and Future Perspectives

edited by Roberta Carbonara and

Alba Fiorentino

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1278 | Submission Open

Keywords: personalized radiotherapy; personalized oncology; adaptive radiotherapy; stereotactic radiotherapy; re-irradiation; immuno-radiotherapy; tumor microenvironment and radiotherapy

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Otolaryngology in Clinical Practice: The Necessity of Personalized Medicine

edited by Jerome Rene Lechien

submission deadline 30 Nov 2025 | 1 articles | Viewed by 745 | Submission Open

Keywords: otolaryngology; otorhinolaryngology; artificial Intelligence; personalized Medicine; treatments

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Pain Medicine: Biomarkers and New Therapeutic Frontiers

edited by Gustavo Fabregat-Cid

submission deadline 30 Nov 2025 | Viewed by 184 | Submission Open

Keywords: pain medicine; biomarkers; omics; neuroimaging; pain phenotyping

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Precision Medicine in Obstetrics and Gynaecology

edited by

Rola Khamisy-Farah

submission deadline 30 Nov 2025 | Viewed by 156 | Submission Open

Keywords: precision medicine; reproductive health; preeclampsia; gestational diabetes; ovarian cancer; targeted therapies; endometriosis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Artificial Intelligence in Personalized Management of Cardiovascular Diseases

edited by

Dominique J. Monlezun

submission deadline 30 Nov 2025 | Viewed by 140 | Submission Open

Keywords: artificial intelligence; cardiovascular disease; health determinants and outcomes; cost effectiveness; policy; ethics; and governance

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Acute Myeloid Leukemia: Current Progress and Future Directions

edited by

Valeria Visconte

and

Luca Guarnera

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1420 | Submission Open

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Complications in Vascular Surgery: Current Updates and Perspectives

edited by

Yamume Tshomba

submission deadline 10 Dec 2025 | Viewed by 172 | Submission Open

Keywords: endoleak; visceral ischaemia; lower limb ischaemia; graft infection; aneurysm shrinkage; sac growing; transient ischemic attack; stroke; deep vein thrombosis; vascular injuries; embolization

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advances in Oral Health: Innovative and Personalized Approaches

edited by

Eleftherios G. Kaklamanos

, Heleni Vastardis and

Miltiadis A. Makrygiannakis

submission deadline 15 Dec 2025 | 3 articles | Viewed by 1964 | Submission Open

Keywords: artificial intelligence; machine learning; genetics; orthodontics; pediatric dentistry; preventive dentistry; periodontology

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Medicine in Psychiatry: Challenges and Opportunities

edited by

Gniewko Więckiewicz

submission deadline 20 Dec 2025 | 7 articles | Viewed by 20474 | Submission Open

Keywords: psychiatry; personalized medicine; epidemiology; public health; addictions; schizophrenia; depression; mental health; precision psychiatry; treatment response; genetic factors; biomarkers; pharmacogenomics; behavioral interventions; comorbidity; substance abuse; neurobiology; psychiatric disorders; psychosocial factors; population health

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advancements in Neurosurgical Oncology: Bridging Neurosurgery and Cancer Neuroscience

edited by

Andres M. Alvarez-Pinzon

submission deadline 20 Dec 2025 | 1 articles | Viewed by 9358 | Submission Open

Keywords: neuro-oncology; cancer progression; neural mechanisms in cancer; brain tumors; neurological implications of cancer; cancer-induced neuropathy; neural stem cells and cancer; neuroinflammation in cancer; neuroimaging in oncology; cancer therapeutics and neurological safety

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Plastic Surgery: New Perspectives and Innovative Techniques

edited by Joseph M. Escandón and

Oscar Javier Manrique

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2797 | Submission Open

Keywords: plastic surgery procedures; free tissue flaps; gender-affirmation surgery; reconstructive procedures; lymphedema; breast cancer; oncologic reconstruction; body contouring; regenerative medicine; stem cell therapy; aesthetic surgery

(This special issue belongs to the Section Regenerative Medicine and Therapeutics)

Integrating Mathematical Modeling and Data Analysis in Personalized Medical Research

edited by

Dorota Bielińska-Wąż

and

Piotr Wąż

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1500 | Submission Open

Keywords: personalized medicine; health informatics; mathematical modeling; data analysis; bioinformatics; artificial intelligence; machine learning

(This special issue belongs to the Section Omics/Informatics)

Personalized Medicine in Dental and Oral Health

edited by

Liliana Georgeta Foia

and

Magda Ecaterina Antohe

submission deadline 25 Dec 2025 | 4 articles | Viewed by 14146 | Submission Open

Keywords: oral health; systemic context; personalized medicine; pharmacogenomics; caries pathology; diagnostics; clinical evaluation; paraclinical evaluation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Laparoscopy, Perioperative Care and Complications in Surgery for Gastrointestinal Diseases

edited by Michał Kisielewski

submission deadline 25 Dec 2025 | 2 articles | Viewed by 3768 | Submission Open

Keywords: laparoscopy; perioperative care; colorectal surgery; minimally invasive surgery; upper digestive surgery; hepatobiliary surgery; postoperative complications

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Artificial Intelligence and Computational Approaches for Clinical Pharmacology and Drug Development

edited by Paraskevi F. Katsakiori and

Panagiotis Papadimitroulas

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2122 | Submission Open

Keywords: personalized medicine; artificial intelligence; optimized therapies; computational models; drug development; clinical pharmacology; machine learning; radiopharmaceuticals; prediction models; digital healthcare

(This special issue belongs to the Section Pharmacogenetics)

Advancing Personalized Medicine: Targeting Oxidative Stress in Neurodegenerative Diseases

edited by Lucia Buccarello

submission deadline 25 Dec 2025 | 1 articles | Viewed by 980 | Submission Open

Keywords: oxidative stress; neurodegeneration; biomarkers; neuroprotection; protein oxidation; neuroinflammation; protein degradation; personalized medicine; intracellular signaling; neuronal death

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Otolaryngology: New Challenges and Future Perspectives

edited by Jerome Rene Lechien

submission deadline 25 Dec 2025 | 1 articles | Viewed by 482 | Submission Open

Keywords: otolaryngology; oral cancer; oncology; head and neck surgery; minimally invasive; laryngology; artificial intelligence; rhinology; ENT; personalized

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Targeted Therapy and Biomarkers for Solid Tumors

edited by Anca Zgură and

Rodica Maricela Anghel

submission deadline 25 Dec 2025 | Viewed by 358 | Submission Open

Keywords: targeted therapy; biomarkers; solid tumors; oncology; cancer immunology; oncology radiotherapy; personalized medicine; molecular targets; drug resistance; translational research

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Diagnosis and Therapy in Renal Cell Carcinoma

edited by Antonio Nacchia

submission deadline 25 Dec 2025 | Viewed by 198 | Submission Open

Keywords: inflammation; kidney cancer; renal cell cancer; inflammatory markers

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Inflammatory Bowel Disease (IBD): Diagnosis and Personalized Treatment

edited by Abigail Raffner (formerly Basson)

submission deadline 25 Dec 2025 | Viewed by 172 | Submission Open

Keywords: inflammatory bowel disease; diagnostic tools; biomarkers; therapeutic strategies; molecular mechanisms; microbiome; genetic predispositions; environmental factors; personalized treatment

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine and Management of Gynecologic Cancer

edited by Hooman Soleymani majd and

Federico Ferrari

submission deadline 25 Dec 2025 | Viewed by 167 | Submission Open

Keywords: proteomic; genomic; biomarkers; precision medicine; molecular profiling; immunotherapy; gynecologic cancer

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Plastic and Reconstructive Surgery: Challenges and Prospects

edited by Johnny Ionut Efanov and Alain Michel Danino

submission deadline 25 Dec 2025 | Viewed by 86 | Submission Open

Keywords: reconstructive surgery; plastic surgery; flaps reconstruction; breast reconstruction; 3D printing; personalized surgery; biomaterials; imaging-assisted surgery; robotics

(This special issue belongs to the Section Regenerative Medicine and Therapeutics)

Cancer Immunotherapy: Current Advancements and Future Perspectives

edited by

Stefano Forte

and

Gianluca Ferini

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15241 | Submission Open

Keywords: personalized immunotherapy; molecular pathways in cancer immunotherapy; precision medicine; molecular markers; molecular bases of abscopal effect; sustained therapeutic response

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Obstetrics and Gynecology and Women's Health—2nd Edition

edited by

Panagiotis N. Tsikouras

submission deadline 31 Dec 2025 | 2 articles | Viewed by 13191 | Submission Open

Keywords: uterine fibroids; uterine myoma; leiomyoma; uterine artery embolization; endometriosis; gynecological surgery; infertility; endocrinology; hysteroscopy; hormonal therapies; personalized medicine

(This special issue belongs to the Section Sex, Gender and Hormone Based Medicine)

Advancing Personalized Spine Surgery Through Minimally Invasive Techniques—Perspectives from Inter-American Society for Minimally Invasive Spine Surgery (SICCMI)

edited by

Kai-Uwe Lewandrowski

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7691 | Submission Open

Keywords: spine surgery; minimally invasive techniques; personalized care; personalized medicine; precision imaging; 3D printing in orthopedics; biomarkers in spinal health; artificial intelligence in surgery; robotics in spine surgery; genomics and spinal disorders; pain management and rehabilitation; surgical navigation systems; biocompatible materials for implants; patient-specific surgical planning; regenerative medicine in spine health; future trends in spinal surgery

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Clinical and Experimental Surgery in Personalized Molecular Medicine

edited by

Apostolos E. Papalois

and Manousos M. Konstadoulakis

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5801 | Submission Open

Keywords: personalized molecular medicine; clinical practice; surgical research; surgical oncology; multidisciplinary approaches

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Biomarkers and Pathogenesis of Infectious Diseases: From Research to Personalized Medicine

edited by

César Henríquez-Camacho

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2894 | Submission Open

Keywords: biomarkers; infectious diseases; pathogenesis; personalized medicine

(This special issue belongs to the Section Disease Biomarkers)

Digital Pathology in Translational Medicine and Clinical Practice

edited by

Alessandro Caputo

Vincenzo L'Imperio

and Filippo Fraggetta

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2870 | Submission Open

Keywords: digital pathology; computational pathology; integrative pathology; computer-aided diagnosis; artificial intelligence; biomarker discovery

(This special issue belongs to the Section Mechanisms of Diseases)

Recent Research on Personalized Approaches to Clinical Therapeutics and Medication Safety

edited by

Sheraz Ali

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2418 | Submission Open

Keywords: clinical therapeutics; medication safety; pharmacotherapy; personalized medicine; treatment optimization; polypharmacy

(This special issue belongs to the Section Epidemiology)

Advances in Transfusion Medicine and Immunological Research

edited by Luca Mele

submission deadline 31 Dec 2025 | Viewed by 228 | Submission Open

Keywords: transfusion medicine; immunological responses; blood safety; cellular therapy; alloimmunity

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine and Surgery in Cardiovascular Disorders

edited by

Quynh Nguyen

and Edward D. Percy

submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open

Keywords: precision medicine; cardiovascular disorders; cardiogenetics; translational medicine; genomic and multi-omics approaches to cardiovascular diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Approaches in Spinal Deformity: Innovations in Diagnosis and Treatment

edited by

Mitchell S. Fourman

submission deadline 31 Dec 2025 | Viewed by 139 | Submission Open

Keywords: adult spinal deformity; preoperative planning; minimally invasive spine surgery; sagittal malalignment; patient-specific hardware; precision medicine; personalized treatment

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Medicine in Platelet Disease

edited by

Tomas Jose Gonzalez-Lopez

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: personalized medicine; platelet-related pathologies; molecular biology; platelet dysfunction; molecular mechanisms; platelets

Artificial Intelligence and Advanced Medical Imaging in Personalized Medicine

edited by Paul Andrei Ștefan and Diana Feier

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: artificial intelligence; medical imaging; personalized medicine; textural analysis; radiomics

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Innovative and Future Trends in Personalized Medicine for Retinal Diseases

edited by Joanna Dolar-Szczasny

submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open

Keywords: retinal disease; age-related macular degeneration; diabetic retinopathy; gene therapy; retinal biomarker; personalized medicine; retinal imaging; molecular profile; artificial intelligence in ophthalmology; inherited retinal diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Treatments in Thoracic Oncology Surgery

edited by

Georg Schlachtenberger

and Alberto Lopez

submission deadline 10 Jan 2026 | 2 articles | Viewed by 2035 | Submission Open

Keywords: minimally invasive surgery; TNM classification; adjuvant treatment; long-term survival

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

From Acute Injury to Personalized Prevention—Developing Modern Strategies

edited by

Markus Gesslein

and

Eduard Kurz

submission deadline 10 Jan 2026 | Viewed by 155 | Submission Open

Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Oxidative Stress and Antioxidant Therapy in Diseases

edited by

Evgenia Lymperaki

and

Ioannis Tsamesidis

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1787 | Submission Open

Keywords: oxidative stress; antioxidants; ROS; diseases; antioxidants

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Cardiovascular and Metabolic Diseases

edited by

Gaetano Santulli

submission deadline 15 Jan 2026 | Viewed by 202 | Submission Open

Keywords: cardiovascular disease; metabolic syndrome; precision health; telemedicine; biomarkers; pharmacogenomics; artificial intelligence; machine learning; epigenetics; diabetes

(This special issue belongs to the Section Mechanisms of Diseases)

New Approaches in Pharmacogenomics

edited by

Su-Jun Lee

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3946 | Submission Open

Keywords: personalized medicine; supporting tools/software for personalized medicine; pharmacogenomic test; pharmacogenomic education; drug response; genomic biomarker; functional genomics; healthcare system

(This special issue belongs to the Section Pharmacogenetics)

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