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Personalized Approaches in Neurosurgery
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Personalized Approaches in Neurosurgery

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 July 2026 | Viewed by 2631

Special Issue Editors

Dr. Alessandro Boaro

E-Mail Website
Guest Editor
Department of Neurosciences, Biomedicine and Movement Sciences, Università di Verona, 37124 Verona, Italy
Interests: neurosurgery; vertebral surgery; artificial intelligence; machine learning; neuronavigation
Dr. Marco Mammi

E-Mail Website
Guest Editor
Department of Neurosurgery, M. Bufalini Hospital, AUSL Romagna, 47521 Cesena, Italy
Interests: neurosurgery; artificial intelligence; statistics

Special Issue Information

Dear Colleagues,

Recent advances in medical technology, data availability, and computational capabilities are opening up new possibilities to tailor the diagnostic, therapeutic, and follow-up journey of neurosurgical patients.

The opportunities unveiled by the application of powerful data analysis techniques, the development of personalized surgical plans for brain and spine surgery, the use of 3D printing technology, and the use of personal digital devices to follow patients over time have the potential to improve outcomes while minimizing risks and reducing costs.

In this Special Issue, we aim to provide readers with a collection of articles regarding the evidence collated, as well as current opportunities and challenges, in the development of personalized approaches for diagnosis, treatment, and follow-up in multiple areas of neurosurgery.

We welcome the submission of original basic science and clinical research papers, proof of concept works, technical notes, and review articles targeting any of these topics.

Dr. Alessandro Boaro
Dr. Marco Mammi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurosurgery
  • neuronavigation
  • neuro-imaging
  • clinical outcomes
  • machine learning

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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20 pages, 2972 KiB  
Review
Intraoperative Monitoring of Sensory Evoked Potentials in Neurosurgery: A Personalized Approach
by Evgeny A. Levin
J. Pers. Med. 2025, 15(1), 26; https://doi.org/10.3390/jpm15010026 - 13 Jan 2025
Viewed by 1724
Abstract
Sensory evoked potentials (EPs), namely, somatosensory, visual, and brainstem acoustic EPs, are used in neurosurgery to monitor the corresponding functions with the aim of preventing iatrogenic neurological complications. Functional deficiency usually precedes structural defect, being initially reversible, and prompt alarms may help surgeons [...] Read more.
Sensory evoked potentials (EPs), namely, somatosensory, visual, and brainstem acoustic EPs, are used in neurosurgery to monitor the corresponding functions with the aim of preventing iatrogenic neurological complications. Functional deficiency usually precedes structural defect, being initially reversible, and prompt alarms may help surgeons achieve this aim. However, sensory EP registration requires presenting multiple stimuli and averaging of responses, which significantly lengthen this procedure. As delays can make intraoperative neuromonitoring (IONM) ineffective, it is important to reduce EP recording time. The possibility of speeding up EP recording relies on differences between IONM and outpatient clinical neurophysiology (CN). Namely, in IONM, the patient is her/his own control, and the neurophysiologist is less constrained by norms and standards than in outpatient CN. Therefore, neurophysiologists can perform a personalized selection of optimal locations of recording electrodes, frequency filter passbands, and stimulation rates. Varying some or all of these parameters, it is often possible to significantly improve the signal-to-noise ratio (SNR) for EPs and accelerate EP recording by up to several times. The aim of this paper is to review how this personalized approach is or may be applied during IONM for recording sensory EPs of each of the abovementioned modalities. Also, the problems hindering the implementation and dissemination of this approach and options for overcoming them are discussed here, as well as possible future developments. Full article
(This article belongs to the Special Issue Personalized Approaches in Neurosurgery)
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12 pages, 6751 KiB  
Case Report
Awake Craniotomy for the Excision of a Pediatric Cerebral Arteriovenous Malformation for Language Preservation: A Case Description
by Melody Long, C. Thiaghu, Tien Meng Cheong, Ramez W. Kirollos, Julian Han, Lee Ping Ng and Sharon Y. Y. Low
J. Pers. Med. 2025, 15(7), 319; https://doi.org/10.3390/jpm15070319 - 15 Jul 2025
Viewed by 298
Abstract
Background: Awake craniotomy (AC) surgeries are less common in the pediatric population in comparison to their adult counterparts. Nonetheless, they can be considered for selected cases whereby speech preservation is paramount during maximal safe resection of intracranial lesions. We describe a case of [...] Read more.
Background: Awake craniotomy (AC) surgeries are less common in the pediatric population in comparison to their adult counterparts. Nonetheless, they can be considered for selected cases whereby speech preservation is paramount during maximal safe resection of intracranial lesions. We describe a case of AC for the excision of a brain arteriovenous malformation (bAVM) with language mapping in a pediatric patient. Methods: A previously well 16-year-old male presented with a spontaneous left frontal intracranial hemorrhage. Neuroimaging confirmed the cause to be a left antero-temporal bAVM centered in the insula. A decision was made for AC bAVM excision with language mapping for speech preservation. Results: As part of the pre-operative preparation, the patient and his caregivers were reviewed by a multidisciplinary team. For the conduct of the AC, the asleep–awake–asleep technique was used with processed EEG to guide anesthesia management. Additional modifications to make the patient comfortable included the avoidance of rigid cranial skull pins, urinary catheterization and central line insertion at the start of the surgery. Conclusions: Our experience concurs with the evidence that AC in children is a feasible option for select individuals. To our knowledge, this is the first detailed case description of a pediatric patient undergoing AC with language mapping for a bAVM. Emphases include a strong rapport between the patient and the managing multidisciplinary team, flexibility to adjust conventional workflows and limitations of neuroimaging adjuncts. Full article
(This article belongs to the Special Issue Personalized Approaches in Neurosurgery)
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