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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Challenges and Advances in Respiratory Diseases

edited by

Vasiliki E. Georgakopoulou

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2611 | Submission Open

Keywords: respiratory diseases; pulmonary disorders; lung health; novel therapies; diagnostic advancements; COVID-19 impact; immunotherapy; respiratory infections; airway diseases; precision medicine

(This special issue belongs to the Section Mechanisms of Diseases)

Precision Medicine in Chronic Kidney Disease: Diagnostics, Treatment, and Outcomes

edited by

Haruhito A. Uchida

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: chronic kidney disease; clinical research; basic research; epidemiology; prevention; public awareness; diagnostics; treatment; outcomes

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Knee Injuries: Personalized Diagnosis, Treatment and Management

edited by Gavin Wood and Fernando Diaz Dilernia

submission deadline 30 Jun 2026 | 1 articles | Viewed by 943 | Submission Open

Keywords: knee osteoarthritis; personalized medicine; precision diagnosis; partial and total knee arthroplasty; periprosthetic frac-ture; complications; functional outcomes; instability; survivorship; periprosthetic joint infection

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advances in Robotic Neurorehabilitation

edited by

Ivo Dumic-Cule

submission deadline 30 Jun 2026 | Viewed by 608 | Submission Open

Keywords: robotic neurorehabilitation; traumatic brain injury; neuroplasticity; stroke; neurodegenerative diseases

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Prevention and Treatment of Cardiovascular Diseases

edited by

Daniela Cornelia Lazăr

and

Vladiana Turi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 598 | Submission Open

Keywords: precision medicine in cardiology; cardiovascular risk stratification; personalized therapeutics; omics technologies in CVD; digital health and cardiovascular care; lifestyle interventions for CVD; arterial stiffness and hypertension; biomarkers for cardiovascular diseases

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Treatment and Management of Sleep Apnea

edited by

Min Young Seo

submission deadline 30 Jun 2026 | Viewed by 542 | Submission Open

Keywords: obstructive sleep apnea; positive airway pressure treatment; upper airway surgery; pharmacological treatment; behavioral therapy; oral appliance

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Heart Failure: New Perspectives and Challenges

edited by

Dimitrios V. Moysidis

submission deadline 30 Jun 2026 | Viewed by 403 | Submission Open

Keywords: heart failure; cardiovascular prevention; risk stratification; cardiovascular pathology; diagnostic modalities; treatment targets

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Minimally Invasive Thoracic Surgery: Risk Assessment and Personalized Perioperative Management

edited by

Marco Andolfi

and Vannucci Jacopo

submission deadline 30 Jun 2026 | Viewed by 367 | Submission Open

Keywords: VATS; ERAS; sublobar resection; risk assessment; minimally invasive thoracic surgery

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Bioinformatics and Computational Biology in Personalized Medicine

edited by

Umar Niazi

submission deadline 30 Jun 2026 | Viewed by 219 | Submission Open

Keywords: bioinformatics; computational biology; artificial intelligence; deep learning; machine learning; personalized medicine; patient stratification; multi-omics data integration; biomarkers; oncology informatics; clinical trial data; causal inference; non-randomized studies; observational studies; clinical research informatics

(This special issue belongs to the Section Omics/Informatics)

Anesthesiology and Pain Management in Clinical Medicine: 2nd Edition

edited by

Paolo Formenti

submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open

Keywords: anesthesiology; pain management; clinical medicine; pharmacology; innovative techniques; evidence-based practices

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Orthopedics and Traumatology: Updates and Challenges

edited by Jan Reinhard and Melanie Ardelt

submission deadline 30 Jun 2026 | Viewed by 150 | Submission Open

Keywords: personalized lumbar spine surgery; patient-specific implants in endoprosthetics; targeted drug delivery in spine and joint surgery; precision medicine in degenerative lumbar disorders; computer-assisted surgical planning; risk-adapted strategies in endoprosthetics; individualized rehabilitation after joint replacement; functional optimization in lumbar fusion and arthroplasty

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Mental Health: Diagnosis, Therapeutic Intervention and Patient Management in the Era of Personalized Medicine

edited by

Ciprian Bacila

and

Mihnea Costin Manea

submission deadline 30 Jun 2026 | Viewed by 96 | Submission Open

Keywords: therapeutic interventions; patient management; personalized medicine; digital psychiatry; multidisciplinary care teams; com-munity mental health; affective disorders; psychotic disorders

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Precision Medicine in Neurodevelopmental Disorders: Challenges and Opportunities

edited by Song-Yu Yang, Xue-Ying He and Manfred Philipp

submission deadline 1 Jul 2026 | 1 articles | Viewed by 1845 | Submission Open

Keywords: intellectual disability; inborn metabolic disorders; X-linked disorders; retarded growth; mitochondrial diseases; genetic and genomic disorders

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

New Insight into Aging and Geriatric Syndromes: Clinical Updates and Perspectives

edited by

Vittorio Dibello

Francesco Panza

and

Vincenzo Solfrizzi

submission deadline 10 Jul 2026 | 9 articles | Viewed by 28221 | Submission Open

Keywords: gerodontology; dementia; mild cognitive impairment (MCI); frontotemporal dementia; frailty; late-life depression; sarcopenia; sensorial impairments; multimorbidity; oral frailty; longevity; biological aging

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Technologies in Plastic, Reconstructive and Aesthetic Surgery: From Imaging to Regeneration

edited by

Dominik Walczak

submission deadline 10 Jul 2026 | Viewed by 117 | Submission Open

Keywords: personalized surgery; plastic and reconstructive surgery; point-of-care ultrasound; 3D printing; digital surgical planning; regenerative medicine; biomaterials; artificial organs

(This special issue belongs to the Section Regenerative Medicine and Therapeutics)

Combating Antimicrobial Resistance: Translational Science to Clinical Practice

edited by Giovanni Gherardi and Roberta Creti

submission deadline 15 Jul 2026 | Viewed by 137 | Submission Open

Keywords: antimicrobial resistance (AMR); One Health approach; new antibacterial strategies; antimicrobial and diagnostic stewardship

(This special issue belongs to the Section Omics/Informatics)

AI-BioEng: Smart Diagnostics and Therapeutic Innovations in Biomedical Engineering

edited by

Antonio Pallotti

submission deadline 15 Jul 2026 | Viewed by 98 | Submission Open

Keywords: AI-based diagnostics; predictive disease modeling; intelligent monitoring systems; wearable and implantable devices; real-time therapeutic feedback; predictive modeling

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Treatment of Neurological Diseases

edited by

Theodora Afrantou

Panagiotis Ioannidis

and

Katerina D. Tzimourta

submission deadline 20 Jul 2026 | 2 articles | Viewed by 7890 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; dementia; epilepsy

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advancing Anesthesia and Pain Control Through Precision Medicine

edited by

Francesco Vetrone

and

Angelo M. Pezzi

submission deadline 20 Jul 2026 | 1 articles | Viewed by 2313 | Submission Open

Keywords: anesthesia; pain control; clinical practice; innovative techniques; evidence-based practice; pharmacology; personalized medicine; perioperative analgesia; chronic pain; acute pain

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Orthopedic Diseases: Advances in Limb Reconstruction

edited by Taylor J. Reif and Jason Shih Hoellwarth

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2090 | Submission Open

Keywords: limb lengthening; limb deformity; malunion; nonunion; limb salvage; amputation reconstruction; osseointegration; osteomyelitis; patient-specific surgery; patient-specific instrumentation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Orthopedic Diseases: Surgical Treatments and Personalized Rehabilitation Strategies

edited by Eyal Yaacobi

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1897 | Submission Open

Keywords: orthopedic treatment; surgical technics; limb salvage; rehabilitation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Pathogenesis and Personalized Management of Asthma

edited by

Mohammed Aref Kyyaly

and S. Hasan Arshad

submission deadline 20 Jul 2026 | Viewed by 239 | Submission Open

Keywords: asthma; pathogenesis; biomarkers; personalized medicine; precision therapy; severe asthma; immunopathology; molecular diagnostics

(This special issue belongs to the Section Mechanisms of Diseases)

Recent Advances in Prenatal Diagnosis and Fetal Therapy

edited by Gabrielle Tonni

submission deadline 20 Jul 2026 | Viewed by 190 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; noninvasive prenatal testing (NIPT); next-generation sequencing (NGS); 3D rendering; personalized medicine; minimally invasive surgery; patient-centered care

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Approaches in Neurosurgery

edited by Alessandro Boaro and Marco Mammi

submission deadline 25 Jul 2026 | 2 articles | Viewed by 6595 | Submission Open

Keywords: neurosurgery; neuronavigation; neuro-imaging; clinical outcomes; machine learning

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Inborn Errors of Metabolism: From Pathomechanisms to Treatment

edited by

Andrés Felipe Leal

and

Carlos J. Almeciga-Diaz

submission deadline 25 Jul 2026 | 2 articles | Viewed by 2906 | Submission Open

Keywords: inherited metabolic disorders; pathway signaling; organelle interactions; immunomodulators; antioxidants; gene therapy

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Pathological Diagnosis

edited by

Gianpietro Volonnino

and

Aniello Maiese

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1174 | Submission Open

Keywords: personalized medicine; pathology; pathological; trauma; toxicology; informed consent

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Diagnosis and Management of Stroke

edited by Rubens José Gagliardi

submission deadline 25 Jul 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: stroke; cerebrovascular disease; carotid disease; epidemiology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Neuroimaging Biomarkers for Precision Medicine in Neuropsychiatry: A Multidisciplinary Update

edited by

Daniel Martins

submission deadline 25 Jul 2026 | Viewed by 387 | Submission Open

Keywords: neuroimaging; neuropsychiatry; psychiatry; psychology; neuroscience; biomarkers; precision medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Radiomics: Unlocking Personalized Insights from Medical Images

edited by

Genti Xhepa

Baptiste Bonnet

and

Alexis Ricoeur

submission deadline 25 Jul 2026 | Viewed by 164 | Submission Open

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Molecular Pathology of Digestive Oncology

edited by

Takashi Murakami

submission deadline 25 Jul 2026 | Viewed by 86 | Submission Open

Keywords: molecular biomarkers; genetic and epigenetic alterations; tumor microenvironment; gut microbiome; carcinogenesis; early detection

(This special issue belongs to the Section Molecular Targeted Therapy)

Novel Challenges and Advances in Orthopaedic and Trauma Surgery

edited by

Dimitrios Kitridis

and

Panagiotis Givissis

submission deadline 30 Jul 2026 | 4 articles | Viewed by 14695 | Submission Open

Keywords: orthopaedic surgery; traumatology; musculoskeletal disorders; innovation in orthopaedics; individualised treatment; post-operative rehabilitation; clinical research

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Cardiothoracic Surgery: Challenges and Future Perspectives

edited by Thomas Theologou

submission deadline 30 Jul 2026 | Viewed by 133 | Submission Open

Keywords: cardiothoracic surgery; minimally invasive surgery; robotic surgery; heart transplantation; lung transplantation; thoracic oncology; perioperative care; artificial intelligence in surgery; surgical innovation; postoperative complications; personalized medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Orthopaedics, 2nd Edition

edited by

Arne Kienzle

and

Henrik Bäcker

submission deadline 31 Jul 2026 | 7 articles | Viewed by 17162 | Submission Open

Keywords: outcomes; orthopedic surgery; traumatology; radiography; complication

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Treatment for Heart Failure

edited by Shunsuke Kiuchi

submission deadline 31 Jul 2026 | 4 articles | Viewed by 7881 | Submission Open

Keywords: hypertension; heart failure; prevention; left ventricular contractility; cardiovascular outcomes; cardiology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

New Advances in Techniques and Personalized Medicine in Cardiology

edited by

Camilla Calvieri

submission deadline 31 Jul 2026 | 1 articles | Viewed by 6689 | Submission Open

Keywords: cardiovascular precision therapy; cardiovascular pharmacological therapy; pharmacogenetics; cardio-imaging; epigenetics; personalized medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Metabolism Disorders

edited by Mehrnaz Abbasi

submission deadline 31 Jul 2026 | Viewed by 266 | Submission Open

Keywords: metabolic syndrome; obesity; insulin resistance; hypertension; type 2 diabetes; energy metabolism; fatty acid oxida-tion; gut microbiota; brown adipose tissue (BAT); white adipose tissue (WAT); nutritional interventions; lifestyle modifications; pharmacological treatments; phytochemicals; vitamins and supplements; public health; epidemiology of obesity; preventive strategies; genetic factors; metabolic health research; adipose tissue function

(This special issue belongs to the Section Mechanisms of Diseases)

Clinical Progress of Diabetic Foot

edited by

Piergiorgio Francia

Roberto Anichini

Leonardo Bocchi

and Alessandra De Bellis

submission deadline 31 Jul 2026 | Viewed by 162 | Submission Open

Keywords: diabetic foot; personalized medicine; advanced therapies; clinical management; biomarkers; diabetes complications; risk assessment; preventive care; artificial intelligence; data science

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Kidney Transplantation

edited by Jon Von Visger

submission deadline 31 Jul 2026 | Viewed by 148 | Submission Open

Keywords: kidney transplantation personalized medicine renal disease nephrology graft survival immunosuppressive therapy recurrent disease patient survival access to transplant

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advances in Ischemic Stroke Management: Toward Precision Medicine

edited by Bruno Kusznir Vitturi

submission deadline 31 Jul 2026 | Viewed by 71 | Submission Open

Keywords: cerebrovascular diseases; ischemic stroke; brain hemorrhage; secondary prevention; thrombolysis; endovascular treatment

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Gastric Cancer Treatment: Recent Progress and Future Perspectives

edited by Gagandeep Brar

submission deadline 10 Aug 2026 | Viewed by 102 | Submission Open

Keywords: gastric cancer; biomarkers; targeted therapy; personalized medicine

(This special issue belongs to the Section Precision Oncology)

Recent Innovations and Artificial Intelligence in Interventional Radiology: A Step Towards Personalized Medicine

edited by

Maurizio Cè

, Giuseppe Pellegrino and Salvatore Alessio Angileri

submission deadline 15 Aug 2026 | 3 articles | Viewed by 4023 | Submission Open

Keywords: interventional radiology; artificial intelligence; augmented reality

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Ehealth, Telemedicine, and AI in the Precision Medicine Era

edited by

Mirella Veras

submission deadline 20 Aug 2026 | 4 articles | Viewed by 24770 | Submission Open

Keywords: digital health; artificial intelligence; telemedicine; telerehabilitation; E-health; precision medicine; remote monitoring; wearable devices; mobile health (mHealth); virtual health; health informatics; machine learning; predictive analytics; personalized medicine; health technology

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Clinical Research of Minimally Invasive Spine Surgery

edited by

Paulo Pereira

and Bertrand Debono

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4349 | Submission Open

Keywords: minimally invasive spine surgery; MISS; surgical techniques; patient outcomes; clinical research; technological advancements; robotics; navigation systems; patient safety; quality of life

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Therapeutic Strategies in Gastrointestinal Surgery

edited by Francesco Santullo

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1852 | Submission Open

Keywords: surgical oncology; cytoreductive surgery; laparoscopic surgery; colorectal surgery; gastric cancer; hipec; pipac; peritoneal metastases

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Mechanisms of Airway Inflammation in Asthma

edited by Kathleen Haley

submission deadline 20 Aug 2026 | 1 articles | Viewed by 873 | Submission Open

Keywords: asthma; inflammation in asthma; targeted therapies; acute respiratory distress syndrome; chronic lung diseases; critical care

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

State of the Art in Cardiac Imaging

edited by

Katarzyna Holcman

submission deadline 25 Aug 2026 | 2 articles | Viewed by 4712 | Submission Open

Keywords: cardiology; imaging; scintigraphy; SPECT; PET; computed tomography; magnetic resonance; echocardiography; heart failure; coronary artery disease

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Interventional Cardiology: Latest Technology, Progress and Challenge

edited by Grzegorz Sobieszek and Maksymilian P. Opolski

submission deadline 25 Aug 2026 | 2 articles | Viewed by 4350 | Submission Open

Keywords: interventional cardiology; chronic total occlusions (CTO); complex and high-risk coronary interventions (CHIP); intravascular lithotripsy (IVL); structural heart interventions; heart failure interventional treatment; electrotherapy; right- and left-ventricle hemodynamic support; left-ventricle assist device (LVAD)

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Management of Heart Failure: From Biomarkers to Clinical Practice

edited by

Andre Rodrigues Durães

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1164 | Submission Open

Keywords: heart failure (HF); cardiac biomarkers; guideline-directed medical therapy (GDMT); risk stratification; HF phenotypes; HF management; digital health

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Gestational Diabetes: Challenges and Cutting-Edge Research

edited by

Athanasios N. Tsartsalis

and

George I. Lambrou

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1108 | Submission Open

Keywords: gestational diabetes; continuous glucose monitor; fetal health; pregnancy; macrosomia; personalized management

(This special issue belongs to the Section Mechanisms of Diseases)

Precision Pathology: Bridging Digital Innovation and Molecular Diagnostics

edited by

Albino Eccher

and Stefano Marletta

submission deadline 25 Aug 2026 | 1 articles | Viewed by 906 | Submission Open

Keywords: precision pathology; digital pathology; molecular diagnostics; artificial intelligence in pathology; computational pathology; multi-omics integration; biomarker discovery; translational medicine

(This special issue belongs to the Section Omics/Informatics)

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