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4.1
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JPM
Special Issues
Personalized Medicine in Pathological Diagnosis
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Personalized Medicine in Pathological Diagnosis

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 457

Special Issue Editors

Dr. Gianpietro Volonnino

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Guest Editor
Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00128 Rome, Italy
Interests: pathological, pathology; trauma; toxicology
Dr. Aniello Maiese

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Guest Editor
Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00128 Rome, Italy
Interests: pathology; histology; immunohistochemistry; miRNAs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pathological diagnosis aims to obtain human tissues or cells through a series of methods and use microscopes and other tools to process and observe the samples in a series of ways to study the causes, pathogenesis, morphological structure, functions, and metabolism of the disease, revealing the occurrence and development of the disease and thus clarifying the nature of the disease.

With our deepened understanding of various diseases, emerging technologies will help the accurate diagnosis of diseases, realize digital pathology, and bring new possibilities for the accurate diagnosis of complex diseases. Personalized medicine, which leverages genetic and molecular information to create treatments tailored to each patient, raises significant ethical challenges. There are issues related to genetic privacy and discrimination based on genetic information, self determination, and equitable access to advanced treatments. It is necessary to find the right balance between innovation and respect for individual rights.

This Special Issue aims to highlight the latest progress in the field of pathology and welcomes original research articles and reviews that focus on recent discoveries in disease diagnosis. We also encourage researchers to submit articles on new tissue biomarkers.

Dr. Gianpietro Volonnino
Dr. Aniello Maiese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • pathology
  • pathological
  • trauma
  • toxicology
  • informed consent

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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13 pages, 3257 KiB  
Article
Vimentin and p53 Immunoreactivity in Cases of Traumatic Brain Injury
by Alice Chiara Manetti, Alessandra De Matteis, Gabriele Napoletano, Raffaele La Russa, Aniello Maiese and Paola Frati
J. Pers. Med. 2025, 15(4), 135; https://doi.org/10.3390/jpm15040135 - 31 Mar 2025
Viewed by 304
Abstract
Background: Traumatic brain injury (TBI) is one of the main causes of death in trauma pathology, especially among the youngest victims. After having evaluated the causality relationship between damage to the brain tissue and death, pathologists should try to estimate the duration [...] Read more.
Background: Traumatic brain injury (TBI) is one of the main causes of death in trauma pathology, especially among the youngest victims. After having evaluated the causality relationship between damage to the brain tissue and death, pathologists should try to estimate the duration between the TBI and death. Immunohistochemistry could be used in this field as a personalized medico-legal approach. This study aims to evaluate the possible role of vimentin and p53 as TBI markers to assess vitality and date the TBI. Methods: Twelve cases of TBI deaths were selected (two women and ten men, with a mean age of 46.83 years). In seven cases, death occurred immediately after the trauma, while in the others, death occurred after some days. An immunohistological study of brain samples using anti-p53 and anti-vimentin antibodies was performed. A semi-quantitative scale was adopted to grade the immunohistochemical reaction. Results: Our results showed a strong relationship between the p53 immunoreaction grade and TBI (X-squared value 10.971, p-value < 0.01), suggesting that p53 expression is enhanced in TBI cases. Vimentin is more expressed when the PTI is longer. Vimentin-immunoreaction was weaker than p53-immunoreaction (+0.75 vs. +1.83 mean values, respectively) in a group predominantly including short post-traumatic interval cases. Conclusions: The present research is limited by the small sample size; however, the molecules tested, vimentin and p53, have shown great potential to be used, in addition to others, as biological markers for the diagnosis and timing of TBI. Full article
(This article belongs to the Special Issue Personalized Medicine in Pathological Diagnosis)
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