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State of the Art in Cardiac Imaging
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State of the Art in Cardiac Imaging

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 2972

Special Issue Editor

Dr. Katarzyna Holcman

E-Mail Website
Guest Editor
1. Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, 31-202 Krakow, Poland
2. Department of Nuclear Medicine, John Paul II Hospital, 31-202 Krakow, Poland
Interests: cardiology; amyloidosis; infective endocarditis; heart failure; echocardiography; nuclear medicine

Special Issue Information

Dear Colleagues,

As we advance into a new era of medical diagnostics, cardiac imaging remains at the forefront, pivotal in transforming patient care and clinical outcomes. This Special Issue  seeks to encapsulate the most recent advancements in multimodal cardiac imaging technologies. Our focus extends across a broad spectrum of clinical applications, highlighting the integration of traditional and innovative imaging modalities to enhance our understanding and management of cardiovascular diseases.

Contributions to this Special Issue will cover groundbreaking research and developments in nuclear imaging techniques, including scintigraphy and positron emission tomography (PET), alongside advanced methodologies in computed tomography (CT), magnetic resonance imaging (MRI) and echocardiography. Each of these modalities offers unique insights, from the molecular and functional analysis provided by nuclear imaging to the detailed anatomical reconstructions possible with CT and MRI, and the real-time functional assessment provided by echocardiography.

This Special Issue aims to bridge diverse clinical scenarios, ranging from common conditions such as coronary artery disease and heart failure to more specialized contexts such as rare genetic disorders, cardiomyopathies, metabolic dysfunctions and infective complications. Through this comprehensive coverage, we hope to foster a deeper understanding of the pathophysiological mechanisms underlying these conditions, enabling more precise diagnostic strategies and therapeutic interventions.

Researchers and clinicians are invited to contribute original research articles, reviews and perspective pieces that explore these areas. By sharing insights from various global experts, this Special Issue will serve as an invaluable resource for those looking to stay abreast of the latest trends and innovations in the field of cardiac imaging, ultimately contributing to enhanced patient care and clinical decision making.

Dr. Katarzyna Holcman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiology
  • imaging
  • scintigraphy
  • SPECT
  • PET
  • computed tomography
  • magnetic resonance
  • echocardiography
  • heart failure
  • coronary artery disease

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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11 pages, 480 KB  
Article
Calcium Hides the Clue: Unraveling the Diagnostic Value of Coronary Calcium Scoring in Cardiac Arrest Survivors
by Ana Margarida Martins, Joana Rigueira, Beatriz Valente Silva, Beatriz Nogueira Garcia, Pedro Alves da Silva, Ana Abrantes, Rui Plácido, Doroteia Silva, Fausto J. Pinto and Ana G. Almeida
J. Pers. Med. 2025, 15(9), 422; https://doi.org/10.3390/jpm15090422 - 3 Sep 2025
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Abstract
Introduction: Coronary artery disease remains one of the most prevalent causes of hospital cardiac arrest (OHCA). Although the benefit of early coronary angiography is well stablished in patients with ST-segment elevation, the benefit and the timing of performing it in other patients [...] Read more.
Introduction: Coronary artery disease remains one of the most prevalent causes of hospital cardiac arrest (OHCA). Although the benefit of early coronary angiography is well stablished in patients with ST-segment elevation, the benefit and the timing of performing it in other patients remain a matter of debate. This is due to the difficulty of identifying those in which an infarction with non-ST-segment elevation is the cause of the OHCA. Coronary artery calcium (CAC) emerges as a reliable predictor of coronary disease and adverse cardiovascular events, detectable even in non-gated chest computed tomography (CT) scans commonly used in OHCA etiological studies, showcasing potential for streamlined risk assessment and management. Aim: The aim of this study was to evaluate if CAC in non-gated CT scans performed in OHCA survivors could act as a good predictor of coronary artery disease on coronary angiography. Methods: This is a single-center, retrospective study of OHCA survivors without ST-segment elevation at presentation. We selected patients for whom a non-gated chest CT was performed and underwent coronary angiography due to the clinical, electrocardiogram (ECG), or echocardiographic suspicion of acute coronary syndrome. An investigator, blinded to the coronary angiography report, evaluated CAC both quantitively (with Agatston score) and qualitatively (visual assessment: absent, mild, moderate, or severe). Results: A total of 44 consecutive patients were included: 70% male, mean age of 60 ± 13 years old. The mean Agatston score was 396 ± 573 AU (Agatston units). Regarding the qualitative assessment, CAC was classified as mild, moderate, and severe in 11%, 25%, and 20% of patients, respectively. The coronary angiography revealed significant coronary lesions in 15 patients (34%), of which 87% were revascularized (80% underwent PCI and 7% CABG). The quantitative CAC assessment accurately predicted the presence of significant lesions on coronary angiography (AUC = 0.90, 95% CI 0.81–0.99, p < 0.001). The presence of moderate or severe CAC by visual assessment also predicted significant lesions on coronary angiography (OR 2.66, 95% CI 1.87–109.71, p = 0.01). There was also a good and significant correlation between the vessel with severe calcification in the CT scan and the culprit vessel evaluated by coronary angiography. CAC was reported in only 16% of the reviewed CTs, most of them with severe calcification. Conclusion: The assessment of CAC in non-gated chest CT scans proved to be feasible and displayed a robust correlation with the presence, severity, and location of coronary artery disease. Its routine use upfront was shown to be an important complement to CT scan reports, ensuring more precise and personalized OHCA management. Full article
(This article belongs to the Special Issue State of the Art in Cardiac Imaging)
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Review

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22 pages, 2103 KB  
Review
Emerging Applications of Positron Emission Tomography in Coronary Artery Disease
by Anna Blach and Jacek Kwiecinski
J. Pers. Med. 2025, 15(3), 100; https://doi.org/10.3390/jpm15030100 - 3 Mar 2025
Viewed by 1962
Abstract
Coronary artery disease remains the leading cause of morbidity and mortality worldwide. With the changing clinical manifestation and novel therapeutical options, precise disease phenotyping becomes increasingly important at the point of care. In the management of coronary artery disease, myocardial perfusion imaging (MPI) [...] Read more.
Coronary artery disease remains the leading cause of morbidity and mortality worldwide. With the changing clinical manifestation and novel therapeutical options, precise disease phenotyping becomes increasingly important at the point of care. In the management of coronary artery disease, myocardial perfusion imaging (MPI) remains the cornerstone of clinical practice. Although traditionally MPI has been primarily performed with single photon emission computed tomography (SPECT), nowadays, given the changing spectrum of the disease, greater precision and additional assessment of myocardial blood flow are desired. Due to the fundamental advantages of PET over SPECT, i.e., higher spatial resolution, accurate attenuation correction for each scan, and higher count rates, the sensitivity and specificity of PET MPI are higher than those of SPECT MPI and are estimated to be approximately 90–92% vs. 83–88% and 81–87% vs. 70–76%, respectively, according to meta-analysis data. Consequently, over the past decade, we have witnessed an increased uptake of positron emission tomography (PET) MPI. With the improved spatial resolution, the ability to quantify myocardial blood flow, and the potential to depict the burden of coronary atherosclerosis with low-dose computed tomography, PET/CT is uniquely positioned to facilitate a comprehensive non-invasive assessment of disease, providing an opportunity for precision medicine. The wealth of data obtained during a single imaging session can be challenging to integrate at the time of image analysis. There has therefore been an increasing interest in developing predefined thresholds or variables (scores) which combine the multidimensional data acquired with PET MPI. Beyond MPI, PET can also serve for the assessment of disease activity at the atherosclerotic plaque level, further refining our understanding of the biology of coronary artery disease and providing hope for enhanced prediction of myocardial infarctions. In this narrative review, we present the current applications of PET MPI in coronary artery disease and focus specifically on two areas that have recently garnered considerable interest—the integration of multiparametric PET MPI data and coronary plaque activity PET imaging. Full article
(This article belongs to the Special Issue State of the Art in Cardiac Imaging)
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