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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dermatology: Molecular Mechanisms, Diagnosis and Therapeutic Targets

edited by

Trinidad Montero-Vilchez

and

Salvador Arias-Santiago

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2383 | Submission Open

Keywords: dermatologic diseases; atopic dermatitis; psoriasis; hidradenitis suppurativa; vitiligo; alopecia; melanoma; scleroderma

(This special issue belongs to the Section Molecular Targeted Therapy)

Novel Applications of Artificial Intelligence in Personalized Medicine

edited by Aikaterini Sakagianni

submission deadline 15 Oct 2025 | 1 articles | Viewed by 665 | Submission Open

Keywords: artificial intelligence ; personalized medicine ; predictive modeling ; genomics ; proteomics ; AI-driven diagnostics ; patient-specific treatment ; drug discovery ; healthcare innovation ; clinical applications of AI

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Multiple Biomarkers for the Diagnosis and Precision Treatment of Depression

edited by

Angelos Halaris

submission deadline 15 Oct 2025 | Viewed by 411 | Submission Open

Keywords: depression; biomarkers; inflammation; autoimmunity; genomics; physiology; radiography

(This special issue belongs to the Section Disease Biomarker)

Gestational Diabetes: Challenges and Cutting-Edge Research

edited by

Athanasios N. Tsartsalis

and

George I. Lambrou

submission deadline 15 Oct 2025 | Viewed by 132 | Submission Open

Keywords: gestational diabetes; continuous glucose monitor; fetal health; pregnancy; macrosomia; personalized management

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Otolaryngology: Novel Prognostic Markers

edited by

Faris F. Brkic

and Wolf-Dieter Baumgartner

submission deadline 20 Oct 2025 | 5 articles | Viewed by 8130 | Submission Open

Keywords: personalized medicine; otorhinolaryngology; otology; head and neck surgery; prognostic markers; individualized treatment

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Hearing Disorder: Diagnosis, Implantation and Latest Research

edited by

Luminița Rădulescu

and

Şerban Vifor Gabriel Berteşteanu

submission deadline 20 Oct 2025 | 1 articles | Viewed by 3689 | Submission Open

Keywords: hearing loss; cochlear implants; hearing preservation; neuroplasticity; outcomes in cochlear implantation; prosthesis fitting; bone-anchored hearing aids; speech perception; sound localization; gene therapy; inner-ear cell regeneration; vestibular disorders; telemedicine

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Hepato-Pancreatic-Biliary Surgery: New Perspectives in Precision Medicine Era

edited by

Gianluca Costa

submission deadline 20 Oct 2025 | 1 articles | Viewed by 966 | Submission Open

Keywords: hepato-pancreatic– biliary surgery; precision medicine; genomics; proteomics; nanotechnologies; molecular pathways; artificial intelligence; predictive modeling

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Cancer Biology and Precision Oncology

edited by Wen-Shin Chang

submission deadline 20 Oct 2025 | Viewed by 165 | Submission Open

Keywords: biomarkers; cancer genomics; diagnosis; single nucleotide polymorphism (SNP); prognosis

(This special issue belongs to the Section Disease Biomarker)

State of the Art in Cardiac Imaging

edited by

Katarzyna Holcman

submission deadline 25 Oct 2025 | 1 articles | Viewed by 1602 | Submission Open

Keywords: cardiology; imaging; scintigraphy; SPECT; PET; computed tomography; magnetic resonance; echocardiography; heart failure; coronary artery disease

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Interventional Cardiology: Latest Technology, Progress and Challenge

edited by Grzegorz Sobieszek and Maksymilian P. Opolski

submission deadline 25 Oct 2025 | Viewed by 503 | Submission Open

Keywords: interventional cardiology; chronic total occlusions (CTO); complex and high-risk coronary interventions (CHIP); intravascular lithotripsy (IVL); structural heart interventions; heart failure interventional treatment; electrotherapy; right- and left-ventricle hemodynamic support; left-ventricle assist device (LVAD)

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Recent Innovations and Artificial Intelligence in Interventional Radiology: A Step Towards Personalized Medicine

edited by

Maurizio Cè

, Giuseppe Pellegrino and Salvatore Alessio Angileri

submission deadline 25 Oct 2025 | Viewed by 156 | Submission Open

Keywords: interventional radiology; artificial intelligence; augmented reality

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Current Therapeutic Strategies and Future Perspectives for Infectious Diseases

edited by Duduzile Ndwandwe

submission deadline 25 Oct 2025 | Viewed by 98 | Submission Open

Keywords: infectious diseases; antimicrobial resistance; therapeutic strategies; pandemic preparedness; innovative treatments; personalized medicine; artificial intelligence in health; global health equity

(This special issue belongs to the Section Epidemiology)

State of the Art in Pathogenesis and Targeted Therapy in Chronic Obstructive Pulmonary Disease

edited by Emanuela Tudorache

submission deadline 30 Oct 2025 | Viewed by 67 | Submission Open

Keywords: COPD; effective treatments; molecular; genetic; inflammation; biomarkers for diagnosis and prognosis; personalized medicine; novel drug delivery systems; patient outcomes; clinical practice

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Innovations in Airway Diseases

edited by

Ourania S. Kotsiou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2879 | Submission Open

Keywords: airway pathophysiology; respiratory therapeutics; novel diagnostic techniques; personalized medicine; clinical trials in airway diseases; innovative treatment strategies; molecular mechanisms; biotechnological advances; environmental impacts; advanced diagnostic tools

(This special issue belongs to the Section Mechanisms of Diseases)

Novel Challenges and Therapeutic Options for Digestive and Liver Diseases—2nd Edition

edited by

Daniel Paramythiotis

and

Eleni Karlafti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 979 | Submission Open

Keywords: digestive disease; gastrointestinal disease; pancreas; gallbladder; liver disease; therapy; management; microbiota; drugs; diagnosis

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Recent Developments in Cancer Biomarkers for Diagnosis and Prognosis

edited by

Raghu Sinha

submission deadline 31 Oct 2025 | Viewed by 441 | Submission Open

Keywords: cancer biomarkers; diagnosis; prognosis; therapy response biomarkers; miRNA; RNA; DNA; and proteins; cell-free biomarkers; saliva; serum; and plasma; inflammation; metabolites

(This special issue belongs to the Section Disease Biomarker)

Current Status and Future Prospects of Histopathology in Cancer Diagnosis

edited by Serena Ammendola and

Valeria Barresi

submission deadline 31 Oct 2025 | Viewed by 438 | Submission Open

Keywords: histopathology; cancer diagnostics; cancer biology; prognostic markers; targeted therapy; immunohistochemistry; molecular biology; digital pathology; artificial intelligence

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Physical Medicine and Rehabilitation: Pediatrics, Adolescents and the Elderly

edited by

José Carmelo Adsuar

submission deadline 31 Oct 2025 | Viewed by 149 | Submission Open

Keywords: personalized medicine; physical medicine; exercise; rehabilitation; pediatrics; adolescents; elderly

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Clinical Updates and Challenges of Gynecological Cancers

edited by Ottavia D’oria,

Violante Di Donato

and Andrea Etrusco

submission deadline 31 Oct 2025 | Viewed by 144 | Submission Open

Keywords: gynecological cancers; ovarian cancer; cervical cancer; endometrial cancer; personalized oncology; biomarkers in gynecology; immunotherapy; surgical oncology; survivorship and quality of life; genetic profiling

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Precision Medicine in Neurodevelopmental Disorders: Challenges and Opportunities

edited by Song-Yu Yang, Xue-Ying He and Manfred Philipp

submission deadline 31 Oct 2025 | Viewed by 111 | Submission Open

Keywords: intellectual disability; inborn metabolic disorders; X-linked disorders; retarded growth; mitochondrial diseases; genetic and genomic disorders

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Towards Personalized Medicine in Breast Cancer

edited by Eun Young Kim

submission deadline 31 Oct 2025 | Viewed by 104 | Submission Open

Keywords: personalized medicine; breast cancer; targeted therapy; immunotherapy; pharmacogenomics; biomarkers; treatment resistance; early detection

(This special issue belongs to the Section Mechanisms of Diseases)

Chronic Obstructive Pulmonary Disease (COPD): From Diagnosis and Comorbidities to Personalized Management and Palliative Care

edited by

Ruxandra Mioara Râjnoveanu

and Florin Mihaltan

submission deadline 10 Nov 2025 | 2 articles | Viewed by 10961 | Submission Open

Keywords: risk factors; systemic inflammation; phenotypes; cardio-pulmonary functional assessment; comorbidities; exacerbations; treatment; rehabilitation; prognosis tools; palliative care; management

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Chemotherapy and Hematopoietic Stem Cell Transplantation

edited by

Luisa Sisinni

submission deadline 15 Nov 2025 | Viewed by 87 | Submission Open

Keywords: hematopoietic stem cell transplantation; chemotherapy toxicity and conditioning regimens; graft-versus-host disease (GVHD) management; immunotherapy and cellular therapies

(This special issue belongs to the Section Regenerative Medicine and Therapeutics)

Ehealth, Telemedicine, and AI in the Precision Medicine Era

edited by

Mirella Veras

submission deadline 20 Nov 2025 | 4 articles | Viewed by 13771 | Submission Open

Keywords: digital health; artificial intelligence; telemedicine; telerehabilitation; E-health; precision medicine; remote monitoring; wearable devices; mobile health (mHealth); virtual health; health informatics; machine learning; predictive analytics; personalized medicine; health technology

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Skin Pathophysiology and Management

edited by

Mohamad Goldust

, Joanna Goldberg and Mahsa Babaei

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5573 | Submission Open

Keywords: skin disease pathophysiology; skin disease diagnosis; skin disease treatment

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Neurodegenerative Diseases: Molecular Pathology and Personalized Treatment

edited by

Oscar Arias-Carrion

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2214 | Submission Open

Keywords: neurodegeneration; molecular pathology; precision medicine; biomarkers; personalized therapeutics

(This special issue belongs to the Section Mechanisms of Diseases)

Mechanisms of Airway Inflammation in Asthma

edited by Kathleen Haley

submission deadline 20 Nov 2025 | Viewed by 400 | Submission Open

Keywords: asthma; inflammation in asthma; targeted therapies; acute respiratory distress syndrome; chronic lung diseases; critical care

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Liquid Biopsy in Lung Cancer: Innovations in Precision Oncology

edited by

Maria Paola Belfiore

and

Valerio Nardone

submission deadline 20 Nov 2025 | Viewed by 199 | Submission Open

Keywords: liquid biopsy; lung cancer; biomarkers; diagnosis; personalized treatment

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions

edited by

Nikolaos Kathopoulis

, Dimitrios Zacharakis and

Athanasios Douligeris

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2330 | Submission Open

Keywords: gynecological endoscopy; minimally invasive and robotic surgeries; personalized gynecological care; gynecological healthcare; personalized diagnosis; genomic profiling; real-time imaging; AI algorithms; biomarker identification

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Recent Advances in Bariatric Surgery

edited by

Maria Sofia

and Andrea Peri

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1947 | Submission Open

Keywords: bariatric surgery; morbid obesity; sleeve gastrectomy; gastric bypass; emerging procedures; early outcomes; long-term results

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Medicine in Gynecology and Obstetrics

edited by

Mǎdǎlin Marius Margan

and

Florin Gorun

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1720 | Submission Open

Keywords: personalized medicine; genetic screening; risk assessment for pregnancy complications; fetal health monitoring; pharmacogenomics; hormone therapy; genetic testing for cancer risk fertility treatments; endometriosis; fibroid management; preventive care and screening

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Molecular Pathology in Cancer Research

edited by Maurizio Martini and Giuseppe Giuffré

submission deadline 25 Nov 2025 | 1 articles | Viewed by 782 | Submission Open

Keywords: molecular pathology; diagnostic pathology; cancer diagnosis; biomarkers; targeted therapy; genomics

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Clinical Management and Personalized Treatment in Digestive Surgery

edited by

Bogdan Severus Gaspar

submission deadline 25 Nov 2025 | Viewed by 292 | Submission Open

Keywords: digestive disease; digestive cancers; gastrointestinal surgery; stomach; pancreas; liver

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Precision Medicine in Spine Surgery: Updates and Challenges

edited by Mark James Lambrechts

submission deadline 25 Nov 2025 | Viewed by 80 | Submission Open

Keywords: spine; orthopedic surgery; neurosurgery; precision; endoscopic spine; artificial disc replacement; spinal deformity; patient-specific alignment

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Head and Neck Disease: Personalized Approaches to Screening and Diagnosis

edited by Heejin Kim

submission deadline 25 Nov 2025 | Viewed by 68 | Submission Open

Keywords: otolaryngology; head and neck; rhinosinusitis; thyroidectomy; tonsillectomy; personalized; screening; diagnosis

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Towards Precision Anesthesia and Pain Management

edited by

Giustino Varrassi

, Joseph V. Pergolizzi and Filomena Puntillo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 8010 | Submission Open

Keywords: precision medicine; anesthesia; pain medicine

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Computer-Assisted Diagnosis and Personalized Treatment of Fracture

edited by Juan Jiménez-Delgado

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3548 | Submission Open

Keywords: fracture diagnosis; computer-assisted simulation; artificial intelligence in orthopedics; medical imaging advances; personalized fracture treatment; computational fracture analysis; surgical planning tools; virtual reality in orthopedics; forensic analysis of fractures; multiscale modeling of bone

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Clinical Advances and Innovations in Reconstructive and Plastic Surgery

edited by Laura Răducu

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2508 | Submission Open

Keywords: plastic surgery; breast reconstruction; robotics; microsurgery; burns injury

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

New Insights into Personalized Medicine for Anesthesia and Pain

edited by

Hyun Kang

and Guen Joo Choi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2167 | Submission Open

Keywords: new insights; personalized medicine; anesthesia; pain management; perioperative analgesia; airway management; perioperative nausea; interventional pain care; critical care; minimally invasive surgery/robotic surgery; mechanical ventilation; chronic pain; acute pain; lumbar/cervical/thoracic/spinal pain; musculoskeletal pain

(This special issue belongs to the Section Personalized Critical Care)

Role of Genetic Tools in Diagnosis and Personalized Treatment for Neurological Diseases

edited by

Federica Scalia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1851 | Submission Open

Keywords: neurological disorders; molecular modeling; bioinformatics; genetic tools; genetic variants; omic technologies; DNA sequencing; newborn screening; therapeutic procedure; mechanism of action

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Epigenetics in Precision Medicine: From Mechanism to Therapy

edited by

Andrea Latini

and

Valerio Caputo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1200 | Submission Open

Keywords: epigenetics; precision medicine; methylation; histone modifications; non-coding RNA

(This special issue belongs to the Section Epigenetic Therapy)

Personalized Medicine in Gastrointestinal Surgical Oncology

edited by

Dae Hoon Kim

and Myoung-Won Son

submission deadline 30 Nov 2025 | 1 articles | Viewed by 848 | Submission Open

Keywords: personalized medicine; gastrointestinal surgical oncology; laparoscopic surgery; robotic surgery; AI in surgery; multimodal treatment; clinical trials; oncological outcomes

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Personalized Radiation Therapy for Cancers: Current Status and Future Perspectives

edited by Roberta Carbonara and

Alba Fiorentino

submission deadline 30 Nov 2025 | 1 articles | Viewed by 736 | Submission Open

Keywords: personalized radiotherapy; personalized oncology; adaptive radiotherapy; stereotactic radiotherapy; re-irradiation; immuno-radiotherapy; tumor microenvironment and radiotherapy

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Pain Medicine: Biomarkers and New Therapeutic Frontiers

edited by Gustavo Fabregat-Cid

submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open

Keywords: pain medicine; biomarkers; omics; neuroimaging; pain phenotyping

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Otolaryngology in Clinical Practice: The Necessity of Personalized Medicine

edited by Jerome Rene Lechien

submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open

Keywords: otolaryngology; otorhinolaryngology; artificial Intelligence; personalized Medicine; treatments

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Precision Medicine in Obstetrics and Gynaecology

edited by

Rola Khamisy-Farah

submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open

Keywords: precision medicine; reproductive health; preeclampsia; gestational diabetes; ovarian cancer; targeted therapies; endometriosis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Artificial Intelligence in Personalized Management of Cardiovascular Diseases

edited by

Dominique J. Monlezun

submission deadline 30 Nov 2025 | Viewed by 89 | Submission Open

Keywords: artificial intelligence; cardiovascular disease; health determinants and outcomes; cost effectiveness; policy; ethics; and governance

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Acute Myeloid Leukemia: Current Progress and Future Directions

edited by

Valeria Visconte

and

Luca Guarnera

submission deadline 10 Dec 2025 | Viewed by 501 | Submission Open

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Complications in Vascular Surgery: Current Updates and Perspectives

edited by

Yamume Tshomba

submission deadline 10 Dec 2025 | Viewed by 132 | Submission Open

Keywords: endoleak; visceral ischaemia; lower limb ischaemia; graft infection; aneurysm shrinkage; sac growing; transient ischemic attack; stroke; deep vein thrombosis; vascular injuries; embolization

(This special issue belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Advances in Oral Health: Innovative and Personalized Approaches

edited by

Eleftherios G. Kaklamanos

, Heleni Vastardis and

Miltiadis A. Makrygiannakis

submission deadline 15 Dec 2025 | Viewed by 126 | Submission Open

Keywords: artificial intelligence; machine learning; genetics; orthodontics; pediatric dentistry; preventive dentistry; periodontology

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

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