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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Depression and Anxiety: Recent Advances in Personalized Treatment and Management

edited by

Stefano Eleuteri

submission deadline 20 Dec 2026 | 2 articles | Viewed by 6086 | Submission Open

Keywords: personalized treatment; mood disorders and anxiety; treatment; therapy; depression and anxiety

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Management and Treatment in Geriatrics

edited by

Carmen da Casa

and

Juan F. Blanco

submission deadline 20 Dec 2026 | 1 articles | Viewed by 1295 | Submission Open

Keywords: geriatrics; personalized health care; artificial intelligence; comprehensive geriatric assessment; ageing; biomedical technology; health promotion; chronic disease management; rehabilitation; pharmacogenetics; neurodegenerative diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

New Approaches in Pharmacogenomics and Functional Genomics

edited by

Su-Jun Lee

submission deadline 20 Dec 2026 | Viewed by 130 | Submission Open

Keywords: personalized medicine; functional genomics; AI-driven tools; machine-learning algorithms; in silico functional prediction platforms; integrative multi-omics analyses; pharmacogenomics education program; drug response; genomic biomarker; healthcare system

(This special issue belongs to the Section Pharmacogenetics)

Personalized Medicine and Surgery in Cardiovascular Disorders

edited by

Quynh Nguyen

and Edward D. Percy

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2192 | Submission Open

Keywords: precision medicine; cardiovascular disorders; cardiogenetics; translational medicine; genomic and multi-omics approaches to cardiovascular diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine in Urology Surgery: New Challenges and Future Perspectives

edited by

Zisis Kratiras

submission deadline 25 Dec 2026 | Viewed by 128 | Submission Open

Keywords: targeted therapy; molecular markers; minimally invasive interventions; robotic surgery; laparoscopic surgery; targeted therapy; urologic surgery

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Cranio-Maxillo-Facial Surgery: Updates and Challenges

edited by

Sergio Olate

submission deadline 28 Dec 2026 | Viewed by 202 | Submission Open

Keywords: maxillofacial surgery; facial plastic surgery; 3D facial surgery; craniomaxillofacial surgery; precision facial treatment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Diagnosis and Treatment of Hematological Malignancies

edited by Adam S. Zayac

submission deadline 30 Dec 2026 | 1 articles | Viewed by 1400 | Submission Open

Keywords: hematologic malignancies; targeted therapies; myeloid neoplasms; non-hodgkin lymphoma; plasma cell neoplasms; supportive care; immunotherapies; cellular therapies

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advances in Atrial Fibrillation and Cardiac Arrhythmias: Mechanisms, Diagnosis, and Therapy

edited by Antonios P. Antoniadis and

Paschalis Karakasis

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6453 | Submission Open

Keywords: atrial fibrillation; arrhythmias; pathophysiological mechanisms; electrophysiological; molecular mechanisms; novel approaches; diagnosis; risk prediction; therapeutic strategies; atrial fibrillation ablation; digital health; artificial intelligence; imaging; wearable devices

(This special issue belongs to the Section Mechanisms of Diseases)

Musculoskeletal Diseases: Diagnosis, Rehabilitation and Personalized Treatment

edited by

Giacomo Farì

submission deadline 31 Dec 2026 | 1 articles | Viewed by 4615 | Submission Open

Keywords: rehabilitation; regenerative medicine; telemedicine; musculoskeletal pain; sport; telemedicine; osteoarthritis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine in Cardiovascular and Metabolic Diseases

edited by

Gaetano Santulli

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3742 | Submission Open

Keywords: cardiovascular disease; metabolic syndrome; precision health; telemedicine; biomarkers; pharmacogenomics; artificial intelligence; machine learning; epigenetics; diabetes

(This special issue belongs to the Section Mechanisms of Diseases)

Translational Research and Novel Therapeutics in Cutaneous Melanoma

edited by Maja Tolušić Levak and Martina Mihalj

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2926 | Submission Open

Keywords: cutaneus melanoma; immunopathology of melanoma; biomarkers; novel treatments; early diagnosis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Breast Cancer: New Advances in Diagnosis and Personalized Therapies

edited by Pierluigi Maria Rinaldi and Sabatino D'Archi

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1958 | Submission Open

Keywords: breast cancer; Breast Imaging Reporting and Data System 3 (BI-RADS 3); imaging; radiomics; therapy; AI

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

The Ethnoracial Diversity of Diabetes: Insights into Epidemiology, Genetics, Disease Management, and Personalized Therapies

edited by

Alberto Barcelo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1891 | Submission Open

Keywords: diabetes disparities; ethnoracial diversity; genetic epidemiology; personalized therapy; health equity

(This special issue belongs to the Section Epidemiology)

From Biomarkers to Breakthroughs: Advancing Lung Cancer Research

edited by

Konstantinos Syrigos

and

Georgios Evangelou

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1012 | Submission Open

Keywords: lung cancer; biomarkers; personalized medicine; molecular diagnostics; targeted therapy; non-small cell lung cancer; small cell lung cancer; resistance mechanisms; translational research; precision oncology

(This special issue belongs to the Section Disease Biomarkers)

Genomics and Precision Medicine

edited by

Trias Thireou

and Louis Papageorgiou

submission deadline 31 Dec 2026 | Viewed by 656 | Submission Open

Keywords: genomics; precision medicine; diagnostics; treatment; genomic test; big data; genomic screening; genomic medicine; genomic biomarker; functional genomics

(This special issue belongs to the Section Omics/Informatics)

Application of Genetic Diagnosis in Pediatrics

edited by Avinash Veerappa

submission deadline 31 Dec 2026 | Viewed by 291 | Submission Open

Keywords: pediatric diagnosis; rare diseases; genome sequencing; exome sequencing; genetic diseases; mutations

(This special issue belongs to the Section Omics/Informatics)

Regenerative Medicine in Cardiovascular Disease

edited by Jaimy Saif and

Claire Stocker

submission deadline 31 Dec 2026 | Viewed by 165 | Submission Open

Keywords: cardiac regeneration; induced pleuripotent stem cells (iPSCs); engineered heart tissue; extracellular vesicles/exosomes; gene and base editing (CRISPR); biomaterials/injectable hydrogels

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Pancreatic Cancer

edited by Nirav Thosani

submission deadline 31 Dec 2026 | Viewed by 124 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; precision oncology; liquid biopsy; tumor microenvironment; radiomics; patient-derived organoids; biomarker-driven therapy; early detection strategies

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Novel and Personalized Treatment Concepts in Gynecologic Cancer—2nd Edition

edited by

Stephan Polterauer

and

Christoph Grimm

submission deadline 15 Jan 2027 | 1 articles | Viewed by 2742 | Submission Open

Keywords: ovarian cancer; endometrial cancer; vulvar cancer; cervical cancer; homologous recombination; targeted therapy; DNA damage repair; biomarkers; imaging; individualized treatment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Molecular Imaging Application in Personalized Diagnosis and Therapy

edited by

Raheleh Roudi

submission deadline 15 Jan 2027 | Viewed by 115 | Submission Open

Keywords: molecular imaging; positron emission tomography; magnetic resonance imaging; optical imaging; artificial intelligence– driven image analysis; personalized diagnostic

(This special issue belongs to the Section Diagnostics in Personalized Medicine)

New Technologies and Personalized Medicine in Gastrointestinal Surgery

edited by

Marco Inama

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2584 | Submission Open

Keywords: new technologies; robotic surgery; surgical innovation; AI in surgery; new materials in surgery; minimally invasive surgery; personalized medicine; theranostics in gastrointestinale cancer

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Cardiac Disease in Pregnancy: Diagnosis, Management and Outcomes

edited by David S. Majdalany

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2438 | Submission Open

Keywords: maternal cardiac disease; cardio-obstetrics; pregnancy and heart disease; cardiac disease in pregnancy; maternal-fetal medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

New Insights into Personalized Care in Advance Care Planning

edited by

Mitsunori Nishikawa

submission deadline 25 Jan 2027 | 3 articles | Viewed by 5759 | Submission Open

Keywords: advance care planning; choices about future medical care; cultural differences; diversity; personalized care choices

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Atrial Fibrillation: Toward Personalized Medicine

edited by

Vincenzo Mirco La Fazia

submission deadline 25 Jan 2027 | 1 articles | Viewed by 3169 | Submission Open

Keywords: atrial fibrillation; personalized medicine; genetic predisposition; electroanatomical mapping; pulsed field ablation; genomics; substrate characterization; tailored ablation strategies

(This special issue belongs to the Section Mechanisms of Diseases)

Advanced Imaging and Artificial Intelligence in Personalized Medicine: Innovations and Future Directions

edited by

Amir Hajjam El Hassani

submission deadline 25 Jan 2027 | 1 articles | Viewed by 2815 | Submission Open

Keywords: precision imaging; personalized medicine; radiomics; molecular imaging; artificial intelligence; imaging biomarkers; theranostics; multi-omics integration; predictive modeling; translational research

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Cardiothoracic Surgery: Treatment and Management

edited by

Dania Nachira

submission deadline 25 Jan 2027 | 2 articles | Viewed by 1836 | Submission Open

Keywords: lung cancer; mediastinum; VATS; RATS; cardiothoracic surgery; new technologies; thoracic anesthesia; regional anesthesia

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Clinical Updates on Personalized Upper Gastrointestinal Surgery

edited by Dimitrios Kehagias

submission deadline 25 Jan 2027 | Viewed by 1355 | Submission Open

Keywords: upper gastrointestinal tract; minimally invasive surgery; anti-reflux surgery; hiatal hernia; achalasia; oesophagogastric resection; personalized treatment; fluorescence guided upper gastrointestinal surgery; anastomotic leakage and perforation of the upper gastrointestinal tract; benign and malignant esophageal diseases; benign and malignant gastric diseases

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Emerging Trends in Diagnostic and Interventional Radiology: Towards Personalized Medicine

edited by

Nicola Maggialetti

submission deadline 25 Jan 2027 | 1 articles | Viewed by 1096 | Submission Open

Keywords: CT; MRI; interventional radiology; personalized medicine; artificial intelligence; radiomics

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Precision Medicine in Gastrointestinal Neoplasms

edited by Juan Torres-Melero and

María Jose Serrano

submission deadline 25 Jan 2027 | Viewed by 660 | Submission Open

Keywords: digestive cancers; molecular biology; gastrointestinal cancers; gynecological cancers

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Otorhinolaryngology: From Diagnostics to Personalized Therapy

edited by

Francesco Giombi

and

Luca Malvezzi

submission deadline 25 Jan 2027 | Viewed by 312 | Submission Open

Keywords: personalized medicine; sinusitis; OSA; molecular antibodies; rhinology; oncology; head and neck; artificial intelligence

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Diagnosis and Treatment of Heart Failure

edited by

Manuel Méndez Bailon

submission deadline 25 Jan 2027 | Viewed by 242 | Submission Open

Keywords: heart failure; acute heart failure; personalized medicine; comorbidities; cardiac electrophysiology; cardiology

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Complex and High-Risk Coronary Interventional Procedures

edited by

Zoltan Ruzsa

, Toth-Gayor Gabor and

Alexandru Achim

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5762 | Submission Open

Keywords: complex high-risk intervention (CHIP); coronary bifurcation; coronary chronic total occlusion; severe coronary calcification; protected PCI; access site I during CHIP procedures

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advances in Colorectal Cancer: Diagnosis and Personalized Treatment

edited by Georgios Polychronidis

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3693 | Submission Open

Keywords: colorectal cancer; diagnosis; personalized medicine; targeted therapy; immunotherapy; liquid biopsy; molecular profiling; surgical oncology; artificial intelligence; precision oncology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Management in Chronic Obstructive Pulmonary Disease (COPD)

edited by Paolo Ruggeri

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1882 | Submission Open

Keywords: COPD; lung function; comorbidities; cardiopulmonary risk; exacerbation; inhalation therapy; early diagnosis; phenotyping

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Therapeutic and Rehabilitation Approaches in Multiple Sclerosis: Challenges and Future Directions

edited by

Angelo Bellinvia

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1605 | Submission Open

Keywords: multiple sclerosis; cognition; disability; lifestyle; environment; risk factors; rehabilitation; treatment; personalized medicine

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Current Trends and Future Challenges in Hepatocellular Carcinoma

edited by

Atish Mukherji

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1480 | Submission Open

Keywords: HCC; MASLD; viral hepatitis; HCC heterogenity; biomarker; therapeutic targeting; personalized medicine; immune therapy

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine for Oral and Maxillofacial Surgery

edited by

Paolo Faccioni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1398 | Submission Open

Keywords: digital dentistry; CAD/CAM; artificial intelligence; omics; oral surgery; maxillofacial surgery

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Ophthalmology: Optometry and Treatment

edited by Concepción De-Hita-Cantalejo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 465 | Submission Open

Keywords: optometry; vision science; binocular vision; dry eyes; computer vision syndrome

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Treatment for Cardiac Surgery: Updates and Challenges

edited by Giacomo Bortolussi and

Tomaso Bottio

submission deadline 31 Jan 2027 | Viewed by 428 | Submission Open

Keywords: cardiac surgery; coronary artery bypass grafting; transcatheter aortic valve replacement; mitral valve repair; heart transplant; sternotomy; wound care; gender

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine of Human Mpox Virus Infections

edited by David Jesse Sanchez

submission deadline 31 Jan 2027 | Viewed by 303 | Submission Open

Keywords: mpox (monkeypox); orthopoxvirus; poxvirus; mpox vaccines; mpox antivirals; molecular diagnostics and genomics of mpox; artificial intelligence in infectious diseases; mpox epidemiology; mpox clade I and clade II sublineages; zoonotic viral infections; emerging infectious diseases

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Navigating Critical Care with Machine Learning: Advances in Personalized Emergency Department Practices

edited by

Filomena Pietrantonio

submission deadline 31 Jan 2027 | Viewed by 226 | Submission Open

Keywords: machine learning; emergency department; critical care; personalized medicine; predictive modeling; real-time decision support; clinical disease

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Inflammation and Immunity in Cardiovascular Diseases

edited by

Nathan A. Holland

submission deadline 15 Feb 2027 | 1 articles | Viewed by 310 | Submission Open

Keywords: cardiovascular inflammation; immune modulation; ischemia– reperfusion injury; personalized medicine; inflammatory biomarkers; cardiometabolic disease; environmental exposures

(This special issue belongs to the Section Mechanisms of Diseases)

Advancements in Personalized Hepatobiliary and Pancreatic Surgery

edited by Spiros Delis

submission deadline 15 Feb 2027 | Viewed by 92 | Submission Open

Keywords: pancreas; HPB surgery; robotic surgery; AI surgery; digestive surgery

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Dentistry: From Multidisciplinary Diagnosis to Precision Treatment

edited by

Giuseppe Lo Giudice

submission deadline 20 Feb 2027 | Viewed by 293 | Submission Open

Keywords: personalized dentistry; precision treatment; multidisciplinary diagnosis; digital dentistry; genomics; artificial intelligence; biomaterials; patient-specific therapy; clinical protocols; preventive dentistry

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Medicine in Orthopedics and Traumatology: Progress and Challenges

edited by Federico Canavese,

Michele Mercurio

and

Marco Sapienza

submission deadline 21 Feb 2027 | 1 articles | Viewed by 1708 | Submission Open

Keywords: orthopedics; traumatology; personalized medicine; patient-specific treatments; custom implants; regenerative medicine; biomechanics; predictive modeling; personalized rehabilitation

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Diagnosis and Treatment for Neurological Diseases

edited by

Natalia Szejko

submission deadline 25 Feb 2027 | 1 articles | Viewed by 4724 | Submission Open

Keywords: movement disorders; Alzheimer’ s disease; Parkinson’ s disease; multiple sclerosis; personalized diagnosis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine and Technology in Oral Science

edited by

Mihaela Ionescu

Sanda Mihaela Popescu

and Veronica Mercu

submission deadline 25 Feb 2027 | 2 articles | Viewed by 2004 | Submission Open

Keywords: precision medicine; personalized dentistry; dental informatics; dental software; dental technology; CAD/CAM technology; dental technique; dental AI; digital dental education; prosthetics; oral surgery orthodontic; maxillofacial surgery; periodontology; oral implantology; dental materials; bone regeneration; tissue regeneration; dental engineering; dental image processing

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Mental Health: Clinical Advances in Personalized Medicine

edited by Hong Xie and Jony Sheynin

submission deadline 28 Feb 2027 | 4 articles | Viewed by 5417 | Submission Open

Keywords: mental health; risk biomarker; neurocircuitry; well-being and resilience; neuroimaging; personalized treatment

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

New Insights into Personalized Medicine for Cardiac Surgery: Clinical Advances in Diagnosis, Treatment, and Prognosis

edited by

Sharaf Eldin Shehada

and Anja Osswald

submission deadline 28 Feb 2027 | 4 articles | Viewed by 5046 | Submission Open

Keywords: cardiovascular disease; patient-centered care; personalized medicine; interdisciplinary approaches; artificial intelligence; prognostic tools; minimally invasive surgery; robotic surgery; bioengineering; cardiovascular genomics

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Otolaryngology—Head and Neck Surgery: Updates and Challenges

edited by Itzhak Braverman

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2533 | Submission Open

Keywords: OSA; rhinology; voice; oncology; personalized ENT surgery; facial palsy; head and neck oncology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

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