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Orthopedic Diseases: Advances in Limb Reconstruction
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Orthopedic Diseases: Advances in Limb Reconstruction

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 196

Special Issue Editors

Dr. Taylor J. Reif

E-Mail Website
Guest Editor
1. Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
2. Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Interests: orthopaedics; trauma; reconstruction surgery; orthopedic surgery; limb-lengthening surgery
Dr. Jason Shih Hoellwarth

E-Mail Website
Guest Editor
1. Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
2. Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Interests: orthopedic trauma; orthopedic surgery; reconstruction surgery; limb-lengthening surgery

Special Issue Information

Dear Colleagues,

Advances in Limb Reconstruction’ broadly includes orthopedic research into limb lengthening or distraction osteogenesis, limb deformity correction, the treatment of malunions and nonunions, osteomyelitis management,  post-neoplastic limb salvage, osseointegration limb reconstruction, and custom or patient specific implants. New approaches, advances to traditional treatment, personalized medicine, or innovative solutions are welcome. Limb reconstruction often requires the creative utilization of the newest developments in orthopedic technology, so research to better understand these tools is prized.

Dr. Taylor J. Reif
Dr. Jason Shih Hoellwarth
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • limb lengthening
  • limb deformity
  • malunion
  • nonunion
  • limb salvage
  • amputation reconstruction
  • osseointegration
  • osteomyelitis
  • patient-specific surgery
  • patient-specific instrumentation

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

10 pages, 449 KiB  
Article
Accuracy of Lower Extremity Alignment Correction Using Patient-Specific Cutting Guides and Anatomically Contoured Plates
by Julia Matthias, S Robert Rozbruch, Austin T. Fragomen, Anil S. Ranawat and Taylor J. Reif
J. Pers. Med. 2025, 15(7), 289; https://doi.org/10.3390/jpm15070289 - 4 Jul 2025
Abstract
Background/Objectives: Limb malalignment disrupts physiological joint forces and predisposes individuals to the development of osteoarthritis. Surgical interventions such as distal femur or high tibial osteotomy aim to restore mechanical balance on weight-bearing joints, thereby reducing long-term morbidity. Accurate alignment is crucial since [...] Read more.
Background/Objectives: Limb malalignment disrupts physiological joint forces and predisposes individuals to the development of osteoarthritis. Surgical interventions such as distal femur or high tibial osteotomy aim to restore mechanical balance on weight-bearing joints, thereby reducing long-term morbidity. Accurate alignment is crucial since it cannot be adjusted after stabilization with plates and screws. Recent advances in personalized medicine offer the opportunity to tailor surgical corrections to each patient’s unique anatomy and biomechanical profile. This study evaluates the benefits of 3D planning and patient-specific cutting guides over traditional 2D planning with standard implants for alignment correction procedures. Methods: We assessed limb alignment parameters pre- and postoperatively in patients with varus and valgus lower limb malalignment undergoing acute realignment surgery. The cohort included 23 opening-wedge high tibial osteotomies and 28 opening-wedge distal femur osteotomies. We compared the accuracy of postoperative alignment parameters between patients undergoing traditional 2D preoperative X-ray planning and those using 3D reconstructions of CT data. Outcome measures included mechanical axis deviation and tibiofemoral angles. Results: 3D reconstructions of computerized tomography data and patient-specific cutting guides significantly reduced the variation in postoperative limb alignment parameters relative to preoperative goals. In contrast, traditional 2D planning with standard non-custom implants resulted in higher deviations from the targeted alignment. Conclusions: Utilizing 3D CT reconstructions and patient-specific cutting guides enhances the accuracy of postoperative limb realignment compared to traditional 2D X-ray planning with standard non-custom implants. Patient-specific instrumentation and personalized approaches represent a key step toward precision orthopedic surgery, tailoring correction strategies to individual patient anatomy and potentially improving long-term joint health. This improvement may reduce the morbidity associated with lower limb malalignment and delay the onset of osteoarthritis. Level of Evidence: Therapeutic Level III. Full article
(This article belongs to the Special Issue Orthopedic Diseases: Advances in Limb Reconstruction)
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