Advancing Tailored Diagnostics and Therapeutics in Autoimmune and Rheumatic Diseases via Integration of Traditional Approaches and AI Technologies

Dear Colleagues, 

Autoimmune and rheumatic diseases are complex disorders characterized by dysregulated immune responses leading to chronic inflammation and tissue damage. Traditional diagnostic and therapeutic approaches have improved patient outcomes, yet the heterogeneity of these diseases calls for more precise and personalized strategies.

Over recent decades, advances in molecular immunology and biomarker discovery have revolutionized disease understanding and management. Targeted therapies such as monoclonal antibodies and cytokine inhibitors marked a shift toward precision medicine, supported by evolving molecular profiling technologies.

This Special Issue aims to highlight cutting-edge research on tailored diagnostics and therapeutics in autoimmune and rheumatic diseases, emphasizing the integration of traditional clinical methods with emerging artificial intelligence (AI) technologies. Our goal is to foster multidisciplinary approaches that accelerate the transition to personalized, effective care.

Key areas include biomarker-driven therapies and molecular profiling, targeted immunotherapies, autoantibody profiling for therapeutic stratification, modulation of the gut microbiota, therapeutic vaccines for immune tolerance, pharmacogenomics and individual response to biologic therapies, as well as AI-driven machine learning models. These innovations collectively promise to refine diagnosis, predict treatment response, and customize therapeutic interventions, ultimately improving patient outcomes.

We welcome different types of manuscript submissions, including original research articles and up-to-date reviews (systematic reviews and meta-analyses).

Dr. Edda Russo
Dr. Francesca Romano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.