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JPM
Special Issues
Towards Precision Anesthesia and Pain Management
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Towards Precision Anesthesia and Pain Management

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 7083

Special Issue Editors

Prof. Dr. Giustino Varrassi

E-Mail Website
Guest Editor
Fondazione Paolo Procacci, Rome, Italy
Interests: pain medicine; anesthesiology
Special Issues, Collections and Topics in MDPI journals
Dr. Joseph V. Pergolizzi

E-Mail Website
Guest Editor
NEMA Research Inc., 868 106th Ave North, Naples, FL 34108, USA
Interests: perioperative and pain medicine; critical and palliative care; pharmacology and drug development
Dr. Filomena Puntillo

E-Mail Website
Guest Editor
Anaesthesia, Intensive Care and Pain Unit, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Piazza G. Cesare 11, 70124 Bari, Italy
Interests: anesthesiology; pain therapy; intensive care; acute postoperative pain; oncologic pain

Special Issue Information

Dear Colleagues,

Precision Medicine is a growing necessity in the clinical approach to patients. This obviously also applies to Anesthesiology and Pain Medicine, which are two important aspects in clinical medicine, especially because they are both very challenging.

The main aim of this Special Issue is to collect all the information that our colleagues involved both in the everyday clinical practice and in research are willing to share with the rest of the scientific world. Communication, especially publication, is always the best way to make aware the others of the results of our experiences. This Special Issue should provide the most updated information on the topic.

We are soliciting mainly review articles, both narrative or systematic, but also meta-analysis and original research.

Prof. Dr. Giustino Varrassi
Dr. Joseph V. Pergolizzi
Dr. Filomena Puntillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision medicine
  • anesthesia
  • pain medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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13 pages, 486 KiB  
Article
Emergency Awake Laparotomy Using Neuraxial Anaesthesia: A Case Series and Literature Review
by Matteo Luigi Giuseppe Leoni, Tommaso Rossi, Marco Mercieri, Giorgia Cerati, David Michael Abbott, Giustino Varrassi, Gaetano Cattaneo, Patrizio Capelli, Manuela Mazzoni and Ruggero Massimo Corso
J. Pers. Med. 2024, 14(8), 845; https://doi.org/10.3390/jpm14080845 - 9 Aug 2024
Viewed by 1892
Abstract
Emergency laparotomy is a surgical procedure associated with significantly higher mortality rates compared to elective surgeries. Awake laparotomy under neuraxial anaesthesia has recently emerged as a promising approach in abdominal surgery to improve patient outcomes. This study aims to evaluate the feasibility and [...] Read more.
Emergency laparotomy is a surgical procedure associated with significantly higher mortality rates compared to elective surgeries. Awake laparotomy under neuraxial anaesthesia has recently emerged as a promising approach in abdominal surgery to improve patient outcomes. This study aims to evaluate the feasibility and potential benefits of using neuraxial anaesthesia as the primary anaesthetic technique in emergency laparotomies. We conducted a case series involving 16 patients who underwent emergency laparotomy for bowel ischemia, perforation, or occlusion. Neuraxial anaesthesia was employed as the main anaesthetic technique. We analysed patient demographics, clinical characteristics, intraoperative details, and postoperative outcomes. The primary outcome measures included the adequacy of postoperative pain control, the incidence of postoperative complications, and mortality rates. Among the 16 patients, adequate postoperative pain control was achieved, with only 2 patients requiring additional analgesia. Postoperative complications, including sepsis, wound dehiscence, and pneumonia, were observed in seven patients (44%). The observed mortality rate was relatively low at 6% (one patient). Notably, conversion to general anaesthesia was not necessary in any of the cases, and no early readmissions were reported. Our findings highlight the feasibility and potential benefits of using neuraxial anaesthesia in emergency laparotomies. The observed low mortality rate and the avoidance of conversion to general anaesthesia suggest that neuraxial anaesthesia may be a useful alternative in emergency settings. However, the occurrence of postoperative complications in 44% of patients indicates the need for cautious patient selection and close monitoring. Further research with larger sample sizes is warranted to fully elucidate the efficacy, safety, and potential impact of this technique on patient outcomes in emergency laparotomies. Full article
(This article belongs to the Special Issue Towards Precision Anesthesia and Pain Management)
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Review

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13 pages, 1097 KiB  
Review
Advances in Basivertebral Nerve Ablation for Chronic Low Back Pain: A Narrative Review
by Sujeivan Mahendram and Paul J. Christo
J. Pers. Med. 2025, 15(3), 119; https://doi.org/10.3390/jpm15030119 - 19 Mar 2025
Viewed by 745
Abstract
Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end [...] Read more.
Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end plate disruption and degeneration, leading to basivertebral nerve-mediated nociception. These degenerative events, described as Modic changes on MRI, provide a means of diagnosis and offer personalized treatment options, like minimally invasive radiofrequency ablation, to help address this source of low back pain. This review focuses on recent advancements, rationale, efficacy, and safety profile intraosseous basivertebral nerve ablation in the treatment of vertebrogenic back pain, and discusses current knowledge gaps that may help guide future research in the field. Full article
(This article belongs to the Special Issue Towards Precision Anesthesia and Pain Management)
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12 pages, 1188 KiB  
Review
Artificial Intelligence-Driven Diagnostic Processes and Comprehensive Multimodal Models in Pain Medicine
by Marco Cascella, Matteo L. G. Leoni, Mohammed Naveed Shariff and Giustino Varrassi
J. Pers. Med. 2024, 14(9), 983; https://doi.org/10.3390/jpm14090983 - 16 Sep 2024
Cited by 7 | Viewed by 2440
Abstract
Pain diagnosis remains a challenging task due to its subjective nature, the variability in pain expression among individuals, and the difficult assessment of the underlying biopsychosocial factors. In this complex scenario, artificial intelligence (AI) can offer the potential to enhance diagnostic accuracy, predict [...] Read more.
Pain diagnosis remains a challenging task due to its subjective nature, the variability in pain expression among individuals, and the difficult assessment of the underlying biopsychosocial factors. In this complex scenario, artificial intelligence (AI) can offer the potential to enhance diagnostic accuracy, predict treatment outcomes, and personalize pain management strategies. This review aims to dissect the current literature on computer-aided diagnosis methods. It also discusses how AI-driven diagnostic strategies can be integrated into multimodal models that combine various data sources, such as facial expression analysis, neuroimaging, and physiological signals, with advanced AI techniques. Despite the significant advancements in AI technology, its widespread adoption in clinical settings faces crucial challenges. The main issues are ethical considerations related to patient privacy, biases, and the lack of reliability and generalizability. Furthermore, there is a need for high-quality real-world validation and the development of standardized protocols and policies to guide the implementation of these technologies in diverse clinical settings. Full article
(This article belongs to the Special Issue Towards Precision Anesthesia and Pain Management)
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