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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Complex Orthopedic Trauma: Diagnosis, Treatment, Managing Complications and Rehabilitation
edited by Philip-Christian Nolte and Benedict Swartman
submission deadline 20 Nov 2025 | 5 articles | Viewed by 5272 | Submission Open
Keywords: orthopedic trauma; fracture; complications; infection; bone; rehabilitation
(This special issue belongs to the Section Orthopedics)
Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease
edited by Joseph B. Selvanayagam and
submission deadline 20 Nov 2025 | 6 articles | Viewed by 4934 | Submission Open
Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research
(This special issue belongs to the Section Cardiovascular Medicine)
Pelvic Organ Prolapse: Current Progress and Clinical Challenges
edited by and Cosimo De Nunzio
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4393 | Submission Open
Keywords: pelvic organ prolapse (POP); postmenopausal; urinary dysfunction; minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical mesh
(This special issue belongs to the Section Obstetrics & Gynecology)
The Association Between Sleep Disorders and Metabolic and Mental Health submission deadline 20 Nov 2025 | 3 articles | Viewed by 3811 | Submission Open
Keywords: sleep medicine; sleep apnea; hypoxia; metabolism; mental health; women’ s health
(This special issue belongs to the Section Mental Health)
Sports Injury Treatment: Innovations in Pain Management, Recovery, and Performance Optimization
edited by Antonio P. Veloso and Javad Sarvestan
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3810 | Submission Open
Keywords: sports injury treatment; pain management; recovery optimization; performance enhancement; advanced rehabilitation; injury prevention; biomechanics; neuromechanics; novel pain relief modalities; performance recovery strategies; wearable technology
(This special issue belongs to the Section Sports Medicine)
Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition) submission deadline 20 Nov 2025 | 5 articles | Viewed by 3720 | Submission Open
Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; dentistry; biological safety
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiovascular Disease in the Elderly: Prevention and Diagnosis
edited by Ioana Dana Alexa, Gabriel Ioan Prada and
submission deadline 20 Nov 2025 | 6 articles | Viewed by 3484 | Submission Open
Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in the Diagnosis and Treatment of Heart Failure submission deadline 20 Nov 2025 | 3 articles | Viewed by 3050 | Submission Open
Keywords: heart failure; diagnosis; treatment; elderly; pluripathology
(This special issue belongs to the Section Cardiology)
New Clinical Advances in Chronic Asthma
edited by Vitaliano Nicola Quaranta
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2743 | Submission Open
Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Orthopedic Infections
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2336 | Submission Open
Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management
(This special issue belongs to the Section Orthopedics)
Current State of Breast Reconstruction
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2166 | Submission Open
Keywords: breast reconstruction; silicone implant; autologous tissue; acellular dermal matrix; seroma; outcome; complication; patient satisfaction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Updates on Cardiac Pacing and Electrophysiology
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2065 | Submission Open
Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation
(This special issue belongs to the Section Cardiology)
PET Imaging in Bone and Non-Bone Diseases
edited by and
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1730 | Submission Open
Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Updates in Lung Ultrasound
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1661 | Submission Open
Keywords: lung ultrasound; intensive care; imaging; ARDS; POCUS
(This special issue belongs to the Section Respiratory Medicine)
Clinical Perspectives in Reconstructive Urethral Surgery
edited by Krishnan Venkatesan
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1580 | Submission Open
Keywords: urethral reconstruction; urethroplasty; urethral stricture; bladder neck stenosis; urinary fistula
(This special issue belongs to the Section Nephrology & Urology)
Cardiopulmonary Resuscitation—from Research to Clinical Implementation
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1372 | Submission Open
Keywords: cardiopulmonary resuscitation; cardiac arrest; basic life support; advanced life support; special circumstances; target temperature management; eCPR-ECLS; survival
(This special issue belongs to the Section Emergency Medicine)
Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1220 | Submission Open
Keywords: optical coherence tomography; optical coherence tomography angiography; visual field testing; glaucoma surgery; MIGS; structure– function relationship in glaucoma
(This special issue belongs to the Section Ophthalmology)
Latest Advances in Glaucoma, Cataract and Refractive Surgery: Expert Views, 2nd Edition submission deadline 20 Nov 2025 | 1 articles | Viewed by 1001 | Submission Open
Keywords: refractive surgery; glaucoma; cataract; intraocular lenses; diagnostic imaging
(This special issue belongs to the Section Ophthalmology)
State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy
edited by Marco Mercieri
submission deadline 20 Nov 2025 | 1 articles | Viewed by 932 | Submission Open
Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets
(This special issue belongs to the Section Clinical Neurology)
Prostate Cancer: Diagnosis, Clinical Management and Prognosis
edited by Giovanni Muto
submission deadline 20 Nov 2025 | 2 articles | Viewed by 813 | Submission Open
Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments
(This special issue belongs to the Section Nephrology & Urology)
Challenges and Opportunities in Geriatric Nephrology and Urology
edited by Giulio Romano
submission deadline 20 Nov 2025 | 1 articles | Viewed by 795 | Submission Open
Keywords: kidney disease; elderly patient; epidemiology; pharmacological therapy; lifestyle diet
(This special issue belongs to the Section Nephrology & Urology)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 638 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
State-of-the-Art Research on Thoracic Surgery submission deadline 20 Nov 2025 | 1 articles | Viewed by 501 | Submission Open
Keywords: 3D imaging; surgical process optimization; robotic surgery; immunotherapy and targeted therapy; novel cancer detection methods; personalized treatment
(This special issue belongs to the Section General Surgery)
Current Status and Future Directions in Cardiac Surgery
edited by Marie-Elisabeth Stelzmüller and Randolph H.L. Wong
submission deadline 20 Nov 2025 | Viewed by 447 | Submission Open
Keywords: innovations; AI; minimally invasive; endoscopic; novel technologies in electrophysiology; hybrid procedures; inno-vative approaches in cardiac surgery and patient care
(This special issue belongs to the Section Cardiology)
Aortic Valve Implantation: Recent Advances and Future Prospects
edited by Suvitesh Luthra and Richard Jabbour
submission deadline 20 Nov 2025 | Viewed by 394 | Submission Open
Keywords: aortic valve replacement; aortic stenosis; paravalvular leak; coronary and structural interventional cardiology; percutaneous coronary artery interventions
(This special issue belongs to the Section Cardiology)
Arthritis: From Diagnosis to Treatment
edited by Andrea Di Matteo and
submission deadline 20 Nov 2025 | Viewed by 353 | Submission Open
Keywords: rheumatoid arthritis; psoriatic arthritis; imaging; ultrasound; DMARDs; differential diagnosis; difficult to treat rheumatoid arthritis; prevention
(This special issue belongs to the Section Immunology)
Challenges and Future Trends in Bariatric Surgery
edited by Maurizio L. de Luca and Amanda Belluzzi
submission deadline 20 Nov 2025 | Viewed by 333 | Submission Open
Keywords: metabolic and bariatric surgery; SADI-S; LSG; RYGB; SASI; OAGB; complications after MBS; long-term outcomes; malnutrition
(This special issue belongs to the Section General Surgery)
Cardiac Imaging in the Diagnosis and Management of Heart Failure
edited by Mahi Lakshmi Ashwath and Allen S. Anderson
submission deadline 20 Nov 2025 | Viewed by 270 | Submission Open
Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain
(This special issue belongs to the Section Cardiology)
New Advances in Uterus and Ovarian Transplantation: 2nd Edition submission deadline 20 Nov 2025 | Viewed by 248 | Submission Open
Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects
edited by
submission deadline 20 Nov 2025 | Viewed by 236 | Submission Open
Keywords: quality of life (QOL); cognition; behavior; stigma; seizure severity; interictal epileptiform discharge (IED); social
(This special issue belongs to the Section Clinical Neurology)
Challenges in Fertility Preservation
edited by and Guido Ambrosini
submission deadline 20 Nov 2025 | Viewed by 232 | Submission Open
Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Research Progress in Pediatric Endocrinology
edited by
submission deadline 20 Nov 2025 | Viewed by 138 | Submission Open
Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening
(This special issue belongs to the Section Clinical Pediatrics)
Minimally Invasive Techniques in Digestive Pathologies
edited by
submission deadline 20 Nov 2025 | Viewed by 121 | Submission Open
Keywords: minimally invasive surgery; laparoscopic techniques; robotic surgery; endoscopic interventions; hybrid surgical approaches; digestive oncology; AI in surgery; surgical innovation; gastrointestinal disorders
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Skin Wound Healing: Clinical Updates and Perspectives
edited by and Norbert Kiss
submission deadline 20 Nov 2025 | Viewed by 107 | Submission Open
Keywords: dermatology; wound care; diagnosis; biomaterials; negative pressure wound therapy
(This special issue belongs to the Section Dermatology)
Acute Ischemic Stroke Management Strategies
edited by
submission deadline 20 Nov 2025 | Viewed by 106 | Submission Open
Keywords: mechanical thrombectomy; leptomeningeal collateral circulation; neuroprotection; reperfusion injury; ischemic penumbra
(This special issue belongs to the Section Clinical Neurology)
Advances in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis
edited by
submission deadline 20 Nov 2025 | Viewed by 104 | Submission Open
Keywords: pulmonary hypertension; interstitial lung disease; idiopathic pulmonary fibrosis; heart failure; mitral valve disease
(This special issue belongs to the Section Respiratory Medicine)
New Therapies for Diabetic Foot Ulcer Management submission deadline 20 Nov 2025 | Viewed by 97 | Submission Open
Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments
(This special issue belongs to the Section Endocrinology & Metabolism)
Low Back Pain: Clinical Treatment and Management submission deadline 20 Nov 2025 | Viewed by 94 | Submission Open
Keywords: exercise; rehabilitation; weight loss; telerehabilitation; pain; physical therapy; treatment; conservative treatment; intervertebral disk displacement; low back pain; sciatica
(This special issue belongs to the Section Clinical Neurology)
Diagnosis and Treatment of Ocular Surface Diseases submission deadline 20 Nov 2025 | Viewed by 91 | Submission Open
Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care
(This special issue belongs to the Section Ophthalmology)
Cardiac MRI: Current Techniques and Future Directions
edited by
submission deadline 20 Nov 2025 | Viewed by 86 | Submission Open
Keywords: cardiac magnetic resonance imaging; technology; sequences; applications; acute coronary syndrome; intravascular imaging; CT-scanner
(This special issue belongs to the Section Cardiology)
Clinical Research in Management of Corneal Diseases
edited by Massimo Busin and Angeli Christy Yu
submission deadline 20 Nov 2025 | Viewed by 80 | Submission Open
Keywords: corneal surgery; corneal transplant; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty; corneal neurotization
(This special issue belongs to the Section Ophthalmology)
Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition submission deadline 20 Nov 2025 | Viewed by 74 | Submission Open
Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses
(This special issue belongs to the Section Orthopedics)
High-Risk Neuroblastoma and Rhabdoid Tumors: New Clinical Insights and Challenges (Second Edition)
edited by and Johannes Hubertus Schulte
submission deadline 20 Nov 2025 | Viewed by 73 | Submission Open
Keywords: neuroblastoma; rhabdoid tumor; autologous stem cell transplantation; allogeneic stem cell transplantation immunotherapy; anti-GD2 antibody; targeted therapy; CAR T-cells
(This special issue belongs to the Section Oncology)
Diagnosis and Treatment of Scoliosis and Spinal Deformity
edited by Anna Rienmueller and Kenny Yat Hong Kwan
submission deadline 20 Nov 2025 | Viewed by 68 | Submission Open
Keywords: scoliosis; spinal deformity; adolescent idiopathic scoliosis (AIS); early onset scoliosis (EOS); neuromuscular scoliosis; adult spinal deformity (ASD); operative treatment; spinal fusion; neuromonitoring in scoliosis and deformity surgery; perioperative risk factors; conservative treatment; bracing therapy; physiotherapy scoliosis-specific exercises (PSSE) and Schroth therapy; spinal biomechanics; scoliosis imaging; low-dose radiation imaging; artificial intelligence in scoliosis; 3D modelling in spinal deformity including surgical planning; predictive modelling in scoliosis progression; biomechanics of spinal curvature; growth modulation; patient-reported outcomes in scoliosis treatment
(This special issue belongs to the Section Orthopedics)
Novel Approaches in Cataract and Refractive Surgery
edited by Stephen T. Armenti
submission deadline 20 Nov 2025 | Viewed by 66 | Submission Open
Keywords: cataract surgery; complex cataract surgery; secondary intraocular lens surgery; refractive surgery (LASIK; PRK; SMILE); astigmatism correction; multifocal intraocular lenses; femtosecond laser; dropless cataract surgery
(This special issue belongs to the Section Ophthalmology)
Clinical Procedures for Diagnosis and Treatment of Cardiovascular Diseases
edited by Ahmad Jabri, Mohammad Alqarqaz, Qais Radaideh and Ahmad Al-Abdouh
submission deadline 20 Nov 2025 | Viewed by 64 | Submission Open
Keywords: cardiovascular disease; diagnostic imaging; minimally invasive procedures; precision medicine; artificial intelligence; interventional cardiology; surgical innovations; patient outcomes; preventive cardiology
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Insights in Maternal–Fetal Medicine
edited by Moti Gulersen
submission deadline 20 Nov 2025 | Viewed by 60 | Submission Open
Keywords: preterm birth; antenatal corticosteroids; preeclampsia; ultrasound; fetal growth; congenital anomalies; infection; maternal morbidity; diabetes; multiple gestation
(This special issue belongs to the Section Obstetrics & Gynecology)
Effect of Long-Term Insomnia on Mental Health—2nd Edition submission deadline 21 Nov 2025 | 1 articles | Viewed by 129 | Submission Open
Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress
(This special issue belongs to the Section Mental Health)
Research Advances in Coagulation Disorders
edited by Alberto Maino
submission deadline 21 Nov 2025 | Viewed by 88 | Submission Open
Keywords: coagulation; bleeding disorders; thrombosis; hemophilia; clotting disorders; hematology
(This special issue belongs to the Section Hematology)
Clinical Features and Management of Psychosis
edited by , and Michael Hadjulis
submission deadline 23 Nov 2025 | Viewed by 384 | Submission Open
Keywords: psychosis; clinical features of psychosis; diagnosis of psychosis; schizophrenia; psychotic depression; affective disorder with psychotic features; psychosis in substance use disorders; psychosis in neurological disorders; psychosis in medical conditions; management of psychosis; treatment of psychosis
(This special issue belongs to the Section Mental Health)
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