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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases

edited by

Spiros G. Delis

submission deadline 25 Nov 2025 | Viewed by 97 | Submission Open

Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 25 Nov 2025 | Viewed by 97 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Diabetic Foot: Emerging Prevention Strategies and Epidemiology

edited by

Vilma Urbančič-Rovan

submission deadline 25 Nov 2025 | Viewed by 91 | Submission Open

Keywords: diabetic foot; foot clinics; epidemiology; prevention; screening; amputation; podiatry

(This special issue belongs to the Section Endocrinology & Metabolism)

Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications

edited by Ioanna Koniari

submission deadline 25 Nov 2025 | Viewed by 89 | Submission Open

Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system

(This special issue belongs to the Section Cardiology)

Advances in the Clinical Management of Perioperative Anesthesia: 2nd Edition

edited by Alessia Mattei, Rita Cataldo and

Alessandro Strumia

submission deadline 25 Nov 2025 | Viewed by 79 | Submission Open

Keywords: perioperative outcomes (surgical; anesthetic; medical); evidence-based care; perioperative guidelines and consensus statements; preoperative evaluation and risk scores; preoperative testing; surgical optimization and enhanced surgical recovery programs; intensive care unit

(This special issue belongs to the Section Anesthesiology)

Treatment and Digital Outcome Assessment in Orthopaedic Trauma

edited by Benedikt Johannes Braun and

Meir Tibi Marmor

submission deadline 25 Nov 2025 | Viewed by 78 | Submission Open

Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)

(This special issue belongs to the Section Orthopedics)

New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery

edited by

Alessandro Coppola

and Immacolata Iannone

submission deadline 25 Nov 2025 | Viewed by 74 | Submission Open

Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease

(This special issue belongs to the Section General Surgery)

Surgery in the Era of Neoadjuvant Immune Checkpoint Inhibitors Therapy for Thoracic Oncology

edited by

Mohsen Ibrahim

submission deadline 25 Nov 2025 | Viewed by 66 | Submission Open

Keywords: neoadjuvant therapy; immune checkpoint inhibitors; unresectable disease; lung cancer; locally advanced lung cancer

(This special issue belongs to the Section General Surgery)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 27 Nov 2025 | Viewed by 110 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Management of Complex Infective Endocarditis

edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas

submission deadline 27 Nov 2025 | Viewed by 61 | Submission Open

Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition

edited by Tsutomu Yasukawa

submission deadline 28 Nov 2025 | 7 articles | Viewed by 5566 | Submission Open

Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium

(This special issue belongs to the Section Ophthalmology)

New Trends in Mechanical Ventilation

edited by

Jan P. Mulier

submission deadline 28 Nov 2025 | 1 articles | Viewed by 4750 | Submission Open

Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance

(This special issue belongs to the Section Anesthesiology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 28 Nov 2025 | 4 articles | Viewed by 2659 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1009 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Current Practices in Cardiovascular Perfusion and Recovery

edited by

Irbaz Hameed

submission deadline 28 Nov 2025 | 1 articles | Viewed by 930 | Submission Open

Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation

(This special issue belongs to the Section Cardiology)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 Nov 2025 | Viewed by 154 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 Nov 2025 | Viewed by 113 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 Nov 2025 | Viewed by 105 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery

edited by

Pantelis Antonakis

and Konstantinos Bramis

submission deadline 28 Nov 2025 | Viewed by 82 | Submission Open

Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract

edited by

Adam Fabisiak

and Hubert Zatorski

submission deadline 28 Nov 2025 | Viewed by 80 | Submission Open

Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Challenges in Maternal-Fetal Medicine

edited by Marzena Laskowska

submission deadline 29 Nov 2025 | 6 articles | Viewed by 6815 | Submission Open

Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Critical Care Medicine

edited by Pietro Caironi

submission deadline 30 Nov 2025 | 11 articles | Viewed by 31610 | Submission Open

Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma

(This special issue belongs to the Section Intensive Care)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 30 Nov 2025 | 16 articles | Viewed by 15308 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

What’s New in Cardiomyopathies: Diagnosis, Treatment and Management

edited by

Cinzia Forleo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6895 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases

(This special issue belongs to the Section Cardiology)

Advancements in Cornea Transplantation

edited by Giulia Coco and Davide Romano

submission deadline 30 Nov 2025 | 7 articles | Viewed by 6538 | Submission Open

Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea

(This special issue belongs to the Section Ophthalmology)

Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era

edited by

Georgios I. Tagarakis

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6072 | Submission Open

Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology

(This special issue belongs to the Section Cardiovascular Medicine)

Maxillo-Facial Surgery: New Insights and Technologies in Head and Neck

edited by Federica Ruggiero

submission deadline 30 Nov 2025 | 6 articles | Viewed by 5922 | Submission Open

Keywords: oral and maxilla-facial surgery; orthognathic surgery; cranio-facial surgery; head and neck surgery; augmented reality; navigation; finite element modeling; virtual surgical planning; patient-specific implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery

edited by Parwis Massoudy and Hilmar C. Dörge

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5477 | Submission Open

Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery

(This special issue belongs to the Section Cardiology)

Preventive, Diagnostic and Therapeutic Strategies for Abdominal Surgery Complications (Second Edition)

edited by

Orestis Ioannidis

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5060 | Submission Open

Keywords: complications; diagnosis; treatment; management; morbidity; abdomen; abdominal surgery; outcome; postoperative

(This special issue belongs to the Section General Surgery)

Clinical Advances in Therapy of Trauma and Surgical Critical Care

edited by Rabail Chaudhry and George W. Williams

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3887 | Submission Open

Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations

(This special issue belongs to the Section Intensive Care)

Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches

edited by Elisabeth M.J.P. Mouws and

Natasja de Groot

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3814 | Submission Open

Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options

(This special issue belongs to the Section Cardiology)

Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities

edited by

Federico Gelpi

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2347 | Submission Open

Keywords: head and neck oncology; free flaps; oral surgery; malformative surgery; traumatology; endoscopy; preprosthetic surgery; reconstructive surgery; vascular malformations; osteonecrosis

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 30 Nov 2025 | 4 articles | Viewed by 2221 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Progress in Rehabilitation Medicine—3rd Edition

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2118 | Submission Open

Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by Alfredo Papa and Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1485 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1365 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1147 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Updates on Rheumatoid Arthritis: 2nd Edition

edited by Francesca Bandinelli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 970 | Submission Open

Keywords: rheumatoid arthritis; rheumatology; treatment; diagnosis; biomarkers; rheumatic disease

(This special issue belongs to the Section Immunology)

Clinical Advances of Breast Surgery and Reconstruction

edited by

Glenda Giorgia Caputo

and Emanuele Cigna

submission deadline 30 Nov 2025 | Viewed by 909 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Innovative Technologies and Approaches in Eye Disease Management and Refractive Surgery

edited by

Hidenaga Kobashi

submission deadline 30 Nov 2025 | Viewed by 821 | Submission Open

Keywords: multifocal intraocular lenses; femtosecond lasers; artificial intelligence; imaging; eye surgery; refractive surgery

(This special issue belongs to the Section Ophthalmology)

Clinical Updates on Prosthodontics

edited by

Rubén Agustín Panadero

and Carla Fons-Badal

submission deadline 30 Nov 2025 | 1 articles | Viewed by 751 | Submission Open

Keywords: dental prosthesis; dental implants; gingival treatment; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition

edited by Nikos Nikolettos and

Angeliki Tiptiri-Kourpeti

submission deadline 30 Nov 2025 | 1 articles | Viewed by 723 | Submission Open

Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Thoracic Surgery Between Tradition and Innovations

edited by Jacopo Vannucci

submission deadline 30 Nov 2025 | 1 articles | Viewed by 723 | Submission Open

Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy

(This special issue belongs to the Section General Surgery)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 30 Nov 2025 | 1 articles | Viewed by 689 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthodontics: State of the Art and Prospects

edited by Beatriz Tarazona-Álvarez and

Natalia Zamora-Martínez

submission deadline 30 Nov 2025 | 1 articles | Viewed by 669 | Submission Open

Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer

edited by Bhaumik Patel

submission deadline 30 Nov 2025 | 1 articles | Viewed by 622 | Submission Open

Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 30 Nov 2025 | 1 articles | Viewed by 598 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 30 Nov 2025 | 1 articles | Viewed by 584 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Orthopedic Surgery: Latest Advances and Perspectives

edited by

Mitchell K. Ng

submission deadline 30 Nov 2025 | 1 articles | Viewed by 492 | Submission Open

Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma

(This special issue belongs to the Section Orthopedics)

Multiparametric Ultrasound Techniques for Liver Disease Assessments

edited by Francesco Giangregorio

submission deadline 30 Nov 2025 | 1 articles | Viewed by 471 | Submission Open

Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Displaying special issue 651-700 on page 14 of 30.

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