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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Updates in Cardiovascular Computed Tomography (CT)

edited by

Antonella Meloni

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3156 | Submission Open

Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection

(This special issue belongs to the Section Cardiovascular Medicine)

Helicobacter pylori-Associated Intestinal Diseases and Beyond

edited by

Antonio Facciorusso

submission deadline 25 Aug 2026 | 3 articles | Viewed by 2859 | Submission Open

Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights

edited by

Amir Nutman

submission deadline 25 Aug 2026 | 3 articles | Viewed by 2558 | Submission Open

Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology

(This special issue belongs to the Section Infectious Diseases)

Current and Emerging Treatment Options in Chronic Liver Diseases

edited by Chandana B. Herath and Michael Praktiknjo

submission deadline 25 Aug 2026 | 2 articles | Viewed by 2437 | Submission Open

Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Early Palliative Care for Patients with Advanced Cancer

edited by

Daryl Bainbridge

submission deadline 25 Aug 2026 | Viewed by 2013 | Submission Open

Keywords: palliative care; early integration; cancer care transitions; communication; symptom management; end of life

(This special issue belongs to the Section Oncology)

Etiology, Diagnosis, and Management of Upper Gastrointestinal Disorders: 2nd Edition

edited by

Hidekazu Suzuki

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1919 | Submission Open

Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; helicobacter; eosinophilic esophagitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hidradenitis Suppurativa: Clinical Diagnosis, Treatment, and Management

edited by Piotr K. Krajewski

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1877 | Submission Open

Keywords: hidradenitis suppurativa; acne inversa; clinical diagnosis; disease severity assessment; biologic therapy; surgical management; comorbidities; quality of life; multidisciplinary care; real world evidence

(This special issue belongs to the Section Dermatology)

Inflammatory Bowel Disease: Clinical Pathogenesis and Management Strategies

edited by

Francesco Colombo

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1872 | Submission Open

Keywords: epithelial barrier dysfunction; intestinal microbiota dysbiosis; minimally invasive surgery in IBDs; disease monitoring; perianal disease treatment; surgical complications in IBD; prehabilitation; stoma formation and management; timing of surgery in IBDs; risk stratification for IBD surgery; patient-reported outcomes post-surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)

edited by

Juan F. Navarro-González

, Carmen Mora-Fernández and

Javier Donate-Correa

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1833 | Submission Open

Keywords: CKD; CKD progression; biomarkers; disease-modifying treatments; diabetic kidney disease; cardiorenal disease; glomerunephritis; genetic kidney diseases

(This special issue belongs to the Section Nephrology & Urology)

Recent Advances in Clinical Pharmacology Based on Pharmacokinetics

edited by

Magdalena Cuciureanu

Cristina Ghiciuc

and

Nina Filip

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1747 | Submission Open

Keywords: PK/PD modeling; dose optimization; clinical decision-making tools; therapeutic drug monitoring; personalized medicine

(This special issue belongs to the Section Pharmacology)

Personalized Therapy and Clinical Outcome for Vasculitis

edited by

Giulia Cassone

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1714 | Submission Open

Keywords: immune-mediated systemic vasculitis; personalized therapy; treatment; outcome; biomarkers; risk factors; management; multidisciplinary care

(This special issue belongs to the Section Immunology & Rheumatology)

Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)

edited by Aikaterini Detoraki

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1463 | Submission Open

Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management

(This special issue belongs to the Section Immunology & Rheumatology)

Knee Arthroplasty: Recent Advances and Future Challenges

edited by Matteo Marullo

submission deadline 25 Aug 2026 | 2 articles | Viewed by 949 | Submission Open

Keywords: knee arthroplasty; implant design; robotic surgery; revision surgery; biomechanics; clinical outcomes; perioperative care; fast-track surgery; digital orthopedics; partial knee replacement

(This special issue belongs to the Section Orthopedics)

Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management

edited by Yujin Kudo

submission deadline 25 Aug 2026 | 1 articles | Viewed by 932 | Submission Open

Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning

(This special issue belongs to the Section Respiratory Medicine)

Gastrointestinal Cancer: Outcomes and Therapeutic Management—2nd Edition

edited by Maximos Frountzas

submission deadline 25 Aug 2026 | 1 articles | Viewed by 834 | Submission Open

Keywords: surgical oncology; gastrointestinal cancer; esophageal; gastric; hepatic; biliary; pancreatic; colon; rectal; neoplasm

(This special issue belongs to the Section Oncology)

Clinical Advancements in Orthopedic Trauma Treatments

edited by

Alessandro Rava

submission deadline 25 Aug 2026 | 2 articles | Viewed by 707 | Submission Open

Keywords: fractures; osteoporosis; fixation; trauma; fracture healing; osteosynthesis; pain

(This special issue belongs to the Section Orthopedics)

Current and Emerging Strategies in Ischemic Stroke: Diagnosis, Treatment, and Prevention

edited by

Dougho Park

Hyoung Seop Kim

and

Jong Hun Kim

submission deadline 25 Aug 2026 | 1 articles | Viewed by 580 | Submission Open

Keywords: diagnosis; digital medicine; epidemiology; ischemic stroke; machine learning; neurorehabilitation; prevention; stroke imaging; treatment

(This special issue belongs to the Section Clinical Neurology)

Bariatric Surgery: Clinical Advances and Future Directions

edited by

Natalia Dowgiałło-Gornowicz

and

Mateusz Wityk

submission deadline 25 Aug 2026 | 1 articles | Viewed by 529 | Submission Open

Keywords: metabolic surgery; bariatric surgery; reflux; laparoscopy; conversion surgery; obesity

(This special issue belongs to the Section General Surgery)

Otologic Disorders and Hearing Impairment: From Diagnosis to Rehabilitation

edited by Andrea Albera and Andrea Canale

submission deadline 25 Aug 2026 | 1 articles | Viewed by 450 | Submission Open

Keywords: otology; hearing loss; cochlear implants; middle ear surgery; otitis media; otosclerosis; auditory rehabilitation; ves-tibular disorders; hearing aid; bone-conduction implants

(This special issue belongs to the Section Otolaryngology)

Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders

edited by

Zala Lužnik Marzidovšek

and Špela Štunf Pukl

submission deadline 25 Aug 2026 | 1 articles | Viewed by 399 | Submission Open

Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery

(This special issue belongs to the Section Ophthalmology)

Complications of Laparoscopic Cholecystectomy: Surgical Outcomes and Clinical Challenges

edited by

Roberto Cirocchi

submission deadline 25 Aug 2026 | Viewed by 311 | Submission Open

Keywords: laparoscopic cholecystectomy; bile duct injury; management of intraoperative injuries; surgical outcomes; postoperative infections

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hand Surgery in Practice: Current Evidence and Emerging Techniques

edited by Guy Rubin

submission deadline 25 Aug 2026 | Viewed by 292 | Submission Open

Keywords: trauma; mallet; burn; nerve; tendon

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Motor Activity and Cognitive Development in Early Childhood: Clinical Implications

edited by

Michele Roccella

and

Daniela Smirni

submission deadline 25 Aug 2026 | Viewed by 291 | Submission Open

Keywords: motor activity; cognitive development; early childhood; neurodevelopmental disorders; autism spectrum disorder; attention-deficit/hyperactivity disorder; developmental coordination disorder; preterm birth

(This special issue belongs to the Section Clinical Neurology)

Spinal Surgery: Recent Advances and Future Perspectives

edited by

Yoshiharu Kawaguchi

submission deadline 25 Aug 2026 | Viewed by 281 | Submission Open

Keywords: spine surgery; diagnostic technology; AI; images; biomarkers; genetics; robotic surgery; minimum invasive surgery; pain control; VR

(This special issue belongs to the Section Orthopedics)

Kidney Transplantation: From Donor Selection to Recipient Outcomes

edited by Basma Merhi and Reginald Gohh

submission deadline 25 Aug 2026 | Viewed by 256 | Submission Open

Keywords: kidney transplantation; end-stage renal disease (ESRD); living-donor kidney transplantation; deceased-donor kidney transplantation; organ shortage; dialysis waiting time; transplant candidate evaluation; immunosuppression

(This special issue belongs to the Section Nephrology & Urology)

Advances in Percutaneous Coronary Intervention: Techniques, Tools and Outcomes

edited by Takashi Ashikaga

submission deadline 25 Aug 2026 | Viewed by 250 | Submission Open

Keywords: percutaneous coronary intervention; orbital atherectomy; coronary artery calcification; intravascular ultrasound (IVUS); optical coherence tomography (OCT)

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates of Pediatric Craniofacial Surgery

edited by Federica Tosi

submission deadline 25 Aug 2026 | Viewed by 240 | Submission Open

Keywords: pediatric craniofacial surgery; craniosynostosis; near-infrared spectroscopy; blood transfusion; perioperative monitoring; pediatric anesthesia; hemodynamic management; tissue oxygenation

(This special issue belongs to the Section Clinical Pediatrics)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 25 Aug 2026 | Viewed by 197 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

Advanced Coronary Physiology and Imaging-Guided Percutaneous Cardiovascular Interventions: Treatment Approaches and Outcomes

edited by Ioannis Skalidis

submission deadline 25 Aug 2026 | Viewed by 176 | Submission Open

Keywords: acute coronary syndromes; chronic coronary syndromes; coronary physiology; intravascular imaging; artificial in-telligence; percutaneous coronary intervention; complex coronary disease

(This special issue belongs to the Section Cardiology)

Novel Approaches to the Treatment and Rehabilitation of Traumatic Brain Injury

edited by

Mario Ganau

submission deadline 25 Aug 2026 | Viewed by 164 | Submission Open

Keywords: traumatic brain injury; rehabilitation; neurotrauma

(This special issue belongs to the Section Brain Injury)

Contemporary Insights in Pulmonary Hypertension: Moving from Algorithms to Phenotypes

edited by Rahul Gupta Argula

submission deadline 25 Aug 2026 | Viewed by 146 | Submission Open

Keywords: pulmonary hypertension; pulmonary arterial hypertension; pulmonary vascular disease; chronic thromboembolic pulmonary hypertension; hypoxic conditions; respiratory therapy

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances and Future Perspective of Subarachnoid Hemorrhage

edited by

Tihamer Molnar

submission deadline 26 Aug 2026 | Viewed by 246 | Submission Open

Keywords: subarachnoid bleeding; neuromonitoring; neuroimaging; delayed cerebral infarction; biomarkers; personalized medicine; AI-guided decision support; outcome

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Musculoskeletal Physiotherapy

edited by

George Georgoudis

submission deadline 26 Aug 2026 | Viewed by 160 | Submission Open

Keywords: telerehabilitation in musculoskeletal medicine; wearable sensors; therapeutic exercise; alternative exercise tech-niques; pain management; musculoskeletal assessment tools

(This special issue belongs to the Section Clinical Rehabilitation)

Orthodontics: State of the Art and Perspectives

edited by

Camelia Szuhanek

and

Irina Nicoleta Zetu

submission deadline 28 Aug 2026 | 16 articles | Viewed by 27481 | Submission Open

Keywords: orthodontics; digital orthodontics; intraoral scanners; facial scanners; treatment planning; interdisciplinary treatment; orthodontic implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Neuromuscular Diseases and Musculoskeletal Disorders

edited by

Anna Christakou

submission deadline 28 Aug 2026 | 4 articles | Viewed by 5405 | Submission Open

Keywords: neuromuscular diseases; osteoporosis; fractures; muscle weakness; muscle intolerance; shoulder dysfunction; myopathy; physiotherapy; rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Stem Cell Transplants

edited by Daniele Avenoso and Michele Malagola

submission deadline 28 Aug 2026 | 3 articles | Viewed by 3642 | Submission Open

Keywords: AML; CML; lymphoma; allo-HSCT; GVHD; MDS; AA

(This special issue belongs to the Section Hematology)

Movement Analysis in Rehabilitation

edited by Paola Contessa

submission deadline 28 Aug 2026 | 2 articles | Viewed by 3315 | Submission Open

Keywords: clinical biomechanics; engineering methods; human movement; motor control; muscle force; musculoskeletal disorders; neuromuscular diseases; posture and balance; rehabilitation

(This special issue belongs to the Section Orthopedics)

Towards a New Paradigm: Opioid-Free and Opioid-Sparing Strategies in Modern Anesthesia

edited by

Kassiani Theodoraki

submission deadline 28 Aug 2026 | 2 articles | Viewed by 3162 | Submission Open

Keywords: opioid-free anesthesia; opioid-sparing strategies; multimodal analgesia; regional anesthesia; non-opioid analgesics; enhanced recovery after surgery (ERAS); perioperative pain management; postoperative analgesia; anesthesia innovation; chronic pain prevention; patient-centered anesthesia; clinical outcomes in anesthesia

(This special issue belongs to the Section Anesthesiology)

Tumor Microenvironment—Current Status and Therapeutic Targets

edited by

Rashi Kalra

submission deadline 28 Aug 2026 | 2 articles | Viewed by 3136 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies

(This special issue belongs to the Section Oncology)

Clinical Therapeutic Advances of Mitral Regurgitation

edited by Angelo Squeri

submission deadline 28 Aug 2026 | 3 articles | Viewed by 2345 | Submission Open

Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography

(This special issue belongs to the Section Cardiovascular Medicine)

Emerging Therapies: Clinical Trials and Insights in Psoriasis

edited by

Beata Kowalewska

and Elżbieta Krajewska-Kułak

submission deadline 28 Aug 2026 | 2 articles | Viewed by 1863 | Submission Open

Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy

(This special issue belongs to the Section Dermatology)

Clinical Updates in Heart Failure: Innovations in Diagnosis, Therapy and Management

edited by Paolo Severino

submission deadline 28 Aug 2026 | 4 articles | Viewed by 1667 | Submission Open

Keywords: heart failure; HFrEF therapy; HFpEF phenotyping; right ventricular dysfunction; renal congestion assessment; diuretic resistance; NT-proBNP dynamics; cardiac imaging; post-discharge management

(This special issue belongs to the Section Cardiology)

Epidemiology Associated Risks and Intervention Strategies of Childhood Obesity

edited by

María M. Morales Suárez-Varela

Antonio Castillo-Paredes

and Eduardo Guzmán-Muñoz

submission deadline 28 Aug 2026 | Viewed by 542 | Submission Open

Keywords: childhood obesity; overweight; eating disorders; nutritional programs; psychological interventions; physical activity exercise; sport; physical well-being; mental well-being; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Drug-Related Problems: Clinical Pharmacy and Safety of Pharmacotherapy

edited by

Mariola Drozd

and

Jakub Pawlikowski

submission deadline 30 Aug 2026 | 3 articles | Viewed by 4494 | Submission Open

Keywords: adverse drug reaction; drug-related problems; drug formulation technology; safety of pharmacotherapy; clinical pharmacy; pharmaceutical care; pharmacology

(This special issue belongs to the Section Pharmacology)

Clinical Updates in Trauma and Emergency Medicine

edited by Yong-Soo Cho and Hyun Ho Ryu

submission deadline 31 Aug 2026 | 5 articles | Viewed by 7723 | Submission Open

Keywords: emergency medicine; epidemiology; cardiovascular disease

(This special issue belongs to the Section Emergency Medicine)

Infectious Diseases and Host Responses: Clinical, Immunological, and Outcome-Orientated Perspectives

edited by

Nicoleta Negruț

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1867 | Submission Open

Keywords: microbiology; infection; resistance; epidemiology; microbiome; prevention; therapy

(This special issue belongs to the Section Infectious Diseases)

Interventional Cardiology: Emerging Insights into Therapeutic Advancements

edited by Dong-Hyeok Kim

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1157 | Submission Open

Keywords: conduction system pacing (CSP); left bundle branch area pacing (LBBAP); interventional electrophysiology; advanced pacing strategies; heart failure device therapy

(This special issue belongs to the Section Cardiology)

The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1128 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease: 2nd Edition

edited by

Giuseppe De Luca

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1061 | Submission Open

Keywords: platelet; anticoagulant therapy; antiplatelet therapy; coronary artery disease (CAD); atrial fibrillation (AF); thromboembolic events; myocardial ischemic; bleeding events; aspirin; clopidogrel; cardiovascular and cerebrovascular diseases; diagnosis and treatment; percutaneous coronary intervention; acute coronary syndrome

(This special issue belongs to the Section Cardiology)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition

edited by