Neurological Injury After Cardiac Arrest: Mechanisms, Prognostication, and Emerging Therapies
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Emergency Medicine".
Deadline for manuscript submissions: 10 March 2026 | Viewed by 22
Special Issue Editors
2. Anglia Ruskin School of Medicine & MTRC, ARU, Chelmsford, Essex, UK
Interests: cardiac arrest; survivors; neurologic rehabilitaton; quality of life; hypoxic-ischaemic brain injury; cognition disorders
Special Issue Information
Dear Colleagues,
Neurological injury remains the principal determinant of outcome after the return of spontaneous circulation. Hypoxic–ischaemic cascades start within minutes, yet opportunities for intervention persist for days. Rapid advances in experimental models are clarifying excitotoxic, inflammatory, and metabolic pathways, while clinical innovations—continuous multimodal monitoring, brain-specific biomarkers, quantitative imaging and refined temperature or perfusion strategies—are redefining both therapy and prognostication. Novel clinical interventions can transform the rehabilitation and care of cardiac arrest survivors with neurological injury. Despite this momentum, translational gaps, methodological heterogeneity, and resource constraints still limit consistent application and guideline development.
This Special Issue of the Journal of Clinical Medicine welcomes original research, systematic reviews, and perspective pieces that clarify cellular mechanisms, test neuroprotective interventions, validate prognostic tools, or address implementation challenges across diverse healthcare settings. By uniting basic scientists and clinicians, we aim to advance evidence-based pathways that improve neurological outcomes after cardiac arrest.
Dr. Marco Mion
Dr. Nikos Gorgoraptis
Guest Editors
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Keywords
- cardiac arrest
- hypoxic–ischaemic brain injury
- neuroprognostication
- neuroprotection
- biomarkers
- targeted tem-perature management
- multimodal monitoring
- neurorehabilitation
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