Applied Cardiorespiratory Physiology in Critical Care Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 2352

Special Issue Editors


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Guest Editor
1. Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-5158, USA
2. OUTCOMES RESEARCH Consortium, Houston, TX 77030, USA
3. Department of Critical Care Medicine, Tzaneio General Hospital, 18536 Piraeus, Greece
Interests: anesthesiology and critical care medicine; cardiovascular dynamics; critical care translational science; resuscitation; translational physiology; integrative physiology; applied physiology
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Guest Editor Assistant
Department of Critical Care Medicine, Tzaneio General Hospital, 18536 Piraeus, Greece
Interests: anesthesiology and critical care medicine; pain management

Special Issue Information

Dear Colleagues,

The provision of medical care to critically ill patients remains challenging despite recent technological and scientific advances. At the same time, our understanding of the cardiopulmonary system, one of the foundations of critical care, is constantly evolving, making it particularly important to account for human physiology when managing complex disease processes. Therefore, from a physiological point of view, mastering cardiorespiratory physiology and identifying the pathophysiological mechanisms and archetypes involved in critical illness allow the physician to apply individualized management options to improve the outcomes of critically ill patients.

The Journal of Clinical Medicine is pleased to introduce a Special Issue dedicated to applied cardiorespiratory physiology in critical care medicine. The aim of this Special Issue is to reinforce our use of the physiological perspectives underpinning our understanding of severe illness and response to therapy and provide an authoritative, integrated presentation of the core information that is essential for clinical decision-making and effective patient management.

We invite physicians-scientists, clinicians, and researchers to submit their work, i.e., original research studies, narrative reviews, and/or systematic reviews and meta-analyses, in all aspects of applied cardiorespiratory physiology including, but not limited to, hemodynamic and respiratory monitoring; volume conditions of the cardiovascular system; venous return; heart-lung interactions; cardiac output; ventriculo-arterial coupling; hemodynamic coherence and microcirculation; adequacy of organ perfusion; diffusion of respiratory gases and oxygen transport to tissue; shock; advanced hemodynamic support; assessment of responsiveness to fluids, vasoactive drugs/inotropes/vasodilators, and blood/blood components; elastic forces and lung volumes; respiratory system resistance; pulmonary ventilation, circulation, and perfusion; respiratory failure; high altitude and flying; high pressure and diving; and individualized, physiology-guided management.

We hope that the content of this Special Issue will offer practical bedside knowledge for clinicians, serving as an invaluable reference for key issues regularly confronted in everyday practice.

Dr. Athanasios Chalkias
Guest Editor

Dr. Paraskevi Tselioti
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • applied physiology
  • critical care medicine
  • cardiovascular physiology
  • respiratory physiology

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Published Papers (1 paper)

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Review

12 pages, 3041 KiB  
Review
Beyond the Lungs: Extrapulmonary Effects of Non-Invasive and Invasive Ventilation Strategies
by Pedro Leme Silva, Davide Chiumello, Tommaso Pozzi and Patricia Rieken Macedo Rocco
J. Clin. Med. 2025, 14(4), 1242; https://doi.org/10.3390/jcm14041242 - 13 Feb 2025
Viewed by 1719
Abstract
Background/Objectives: Non-invasive respiratory support and invasive mechanical ventilation are critical interventions that can induce significant changes not only in the lungs but also in extra-pulmonary organs, which are often overlooked. Understanding the extra-pulmonary effects of non-invasive respiratory support and invasive mechanical ventilation [...] Read more.
Background/Objectives: Non-invasive respiratory support and invasive mechanical ventilation are critical interventions that can induce significant changes not only in the lungs but also in extra-pulmonary organs, which are often overlooked. Understanding the extra-pulmonary effects of non-invasive respiratory support and invasive mechanical ventilation is crucial since it can help prevent or mitigate complications and improve outcomes. This narrative review explores these consequences in detail and highlights areas that require further research. Main Text: Non-invasive respiratory support and invasive mechanical ventilation can significantly impact various extrapulmonary organs. For instance, some ventilation strategies can affect venous return from the brain, which may lead to neurological sequelae. In the heart, regardless of the chosen ventilation method, increased intrathoracic pressure (ITP) can also reduce venous return to the heart. This reduction in turn can decrease cardiac output, resulting in hypotension and diminished perfusion of vital organs. Conversely, in certain situations, both ventilation strategies may enhance cardiac function by decreasing the work of breathing and lowering oxygen consumption. In the kidneys, these ventilation methods can impair renal perfusion and function through various mechanisms, including hemodynamic changes and the release of stress hormones. Such alterations can lead to acute kidney injury or exacerbate pre-existing renal conditions. Conclusions: This review emphasizes the critical importance of understanding the extensive mechanisms by which non-invasive respiratory support and invasive mechanical ventilation affect extrapulmonary organs, including neurological, cardiovascular, and renal systems. Such knowledge is essential for optimizing patient care and improving outcomes in critical care settings. Full article
(This article belongs to the Special Issue Applied Cardiorespiratory Physiology in Critical Care Medicine)
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