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Coronary Artery Disease: Diagnosis, Treatment Challenges, and Emerging Therapy
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Coronary Artery Disease: Diagnosis, Treatment Challenges, and Emerging Therapy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1000

Special Issue Editors

Dr. Athanasios Samaras

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Guest Editor
Second Cardiology Department, Hippokrateion University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: interventional cardiology; coronary artery disease; cardiovascular imaging; cardiovascular disease; artificial intelligence; digital cardiology
Dr. Andreas S. Papazoglou

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Guest Editor
Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: interventional cardiology; coronary artery disease; cardiovascular disease; percutaneous coronary interventions; myocardial infarction; digital pathology
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Special Issue Information

Dear Colleagues,

Coronary artery disease remains a predominant cause of morbidity and mortality globally, despite remarkable advancements in cardiovascular medicine. Over the past few decades, innovations in diagnosis, medical therapy, and interventional techniques have substantially improved patient outcomes, yet many challenges persist.

This Special Issue seeks to present comprehensive insights into the evolving landscape of diagnosis, management, and emerging therapeutic approaches in relation to coronary artery disease. It aims to foster scholarly discussion on unresolved clinical challenges and future directions in the field.

Recent breakthroughs in percutaneous coronary intervention, cardiovascular imaging, and biomarker discovery have revolutionized the clinical approach to coronary artery disease. This Special Issue will highlight such state-of-the-art research, which has the potential to shape contemporary and future clinical practice.

We invite submission of original research articles, systematic reviews, and narrative reviews that address novel diagnostic strategies, therapeutic innovations, treatment challenges, biomarker utilization, and the integration of digital technologies in coronary artery disease management.

Dr. Athanasios Samaras
Dr. Andreas Papazoglou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary artery disease
  • percutaneous coronary intervention
  • cardiovascular disease
  • emerging therapies
  • treatment challenges
  • biomarkers
  • interventional cardiology

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Published Papers (1 paper)

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50 pages, 10250 KB  
Systematic Review
Diagnostic Accuracy of Exercise Stress Testing, Stress Echocardiography, Myocardial Scintigraphy, and Cardiac Magnetic Resonance for Obstructive Coronary Artery Disease: Systematic Reviews and Meta-Analyses of 104 Studies Published from 1990 to 2025
by Andrea Sonaglioni, Alessio Polymeropoulos, Massimo Baravelli, Gian Luigi Nicolosi, Michele Lombardo and Giuseppe Biondi-Zoccai
J. Clin. Med. 2025, 14(17), 6238; https://doi.org/10.3390/jcm14176238 - 4 Sep 2025
Viewed by 933
Abstract
Background: Since the 1990s, numerous investigations have assessed the diagnostic effectiveness—specifically sensitivity, specificity, and accuracy—of exercise stress testing (EST), stress echocardiography (SE), stress myocardial single-photon emission computed tomography (SPECT), and stress cardiac magnetic resonance imaging (CMR). However, the outcomes of these studies have [...] Read more.
Background: Since the 1990s, numerous investigations have assessed the diagnostic effectiveness—specifically sensitivity, specificity, and accuracy—of exercise stress testing (EST), stress echocardiography (SE), stress myocardial single-photon emission computed tomography (SPECT), and stress cardiac magnetic resonance imaging (CMR). However, the outcomes of these studies have often been inconsistent and inconclusive. To provide a clearer comparison, we conducted systematic reviews and meta-analyses aimed at quantitatively evaluating and comparing the aggregated diagnostic performance of these four commonly used techniques for detecting coronary artery disease (CAD). Methods: A comprehensive search of PubMed, Scopus, Embase, Cochrane Library, and Web of Science was conducted to identify cohort studies evaluating the diagnostic accuracy of EST, SE, stress myocardial SPECT, and stress CMR in symptomatic patients with suspected or confirmed CAD. The main goal was to compare their diagnostic value by pooling sensitivity and specificity results. Each study’s data were extracted in terms of true positives, false positives, true negatives, and false negatives. Results: A total of 104 studies, comprising 16,824 symptomatic individuals with either suspected or known CAD, met the inclusion criteria. The pooled sensitivities for CAD detection were 0.66 (95% CI: 0.59–0.72, p < 0.001) for EST, 0.81 (95% CI: 0.79–0.83, p < 0.001) for SE, 0.82 (95% CI: 0.78–0.85, p < 0.001) for stress myocardial SPECT, and 0.83 (95% CI: 0.81–0.85, p < 0.001) for stress CMR. Corresponding specificities were 0.61 (95% CI: 0.55–0.67, p < 0.001), 0.85 (95% CI: 0.82–0.87, p < 0.001), 0.74 (95% CI: 0.70–0.78, p < 0.001), and 0.89 (95% CI: 0.86–0.92, p < 0.001), respectively. Considerable heterogeneity was observed across the studies, as reflected by I2 values ranging from 82.5% to 92.5%. Egger’s generalized test revealed statistically significant publication bias (p < 0.05 for all methods), likely due to the influence of smaller studies reporting more favorable results. Despite this, sensitivity analyses supported the overall robustness and reliability of the pooled findings. Conclusions: Among the diagnostic tools assessed, EST demonstrated the lowest accuracy for detecting obstructive CAD, whereas stress CMR exhibited the highest. Although stress myocardial SPECT showed strong sensitivity, its specificity was comparatively limited. SE emerged as the most balanced option, offering good diagnostic accuracy combined with advantages such as broad availability, cost-effectiveness, and the absence of ionizing radiation. Full article
(This article belongs to the Special Issue Coronary Artery Disease: Diagnosis, Treatment Challenges, and Emerging Therapy)
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