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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives

edited by Balakrishnan M. Mahesh

submission deadline 25 Nov 2025 | Viewed by 72 | Submission Open

Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion

(This special issue belongs to the Section Cardiology)

Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases

edited by

Spiros G. Delis

submission deadline 25 Nov 2025 | Viewed by 70 | Submission Open

Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 25 Nov 2025 | Viewed by 69 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 25 Nov 2025 | Viewed by 69 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Diabetic Foot: Emerging Prevention Strategies and Epidemiology

edited by

Vilma Urbančič-Rovan

submission deadline 25 Nov 2025 | Viewed by 68 | Submission Open

Keywords: diabetic foot; foot clinics; epidemiology; prevention; screening; amputation; podiatry

(This special issue belongs to the Section Endocrinology & Metabolism)

Treatment and Digital Outcome Assessment in Orthopaedic Trauma

edited by Benedikt Johannes Braun and

Meir Tibi Marmor

submission deadline 25 Nov 2025 | Viewed by 64 | Submission Open

Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)

(This special issue belongs to the Section Orthopedics)

Advances in the Clinical Management of Perioperative Anesthesia: 2nd Edition

edited by Alessia Mattei, Rita Cataldo and

Alessandro Strumia

submission deadline 25 Nov 2025 | Viewed by 59 | Submission Open

Keywords: perioperative outcomes (surgical; anesthetic; medical); evidence-based care; perioperative guidelines and consensus statements; preoperative evaluation and risk scores; preoperative testing; surgical optimization and enhanced surgical recovery programs; intensive care unit

(This special issue belongs to the Section Anesthesiology)

Surgery in the Era of Neoadjuvant Immune Checkpoint Inhibitors Therapy for Thoracic Oncology

edited by

Mohsen Ibrahim

submission deadline 25 Nov 2025 | Viewed by 52 | Submission Open

Keywords: neoadjuvant therapy; immune checkpoint inhibitors; unresectable disease; lung cancer; locally advanced lung cancer

(This special issue belongs to the Section General Surgery)

New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery

edited by

Alessandro Coppola

and Immacolata Iannone

submission deadline 25 Nov 2025 | Viewed by 46 | Submission Open

Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease

(This special issue belongs to the Section General Surgery)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 27 Nov 2025 | Viewed by 79 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Management of Complex Infective Endocarditis

edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas

submission deadline 27 Nov 2025 | Viewed by 53 | Submission Open

Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation

(This special issue belongs to the Section Cardiology)

New Trends in Mechanical Ventilation

edited by

Jan P. Mulier

submission deadline 28 Nov 2025 | 1 articles | Viewed by 3969 | Submission Open

Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance

(This special issue belongs to the Section Anesthesiology)

Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition

edited by Tsutomu Yasukawa

submission deadline 28 Nov 2025 | 5 articles | Viewed by 3319 | Submission Open

Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium

(This special issue belongs to the Section Ophthalmology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1208 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 Nov 2025 | 1 articles | Viewed by 336 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 Nov 2025 | Viewed by 127 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Current Practices in Cardiovascular Perfusion and Recovery

edited by

Irbaz Hameed

submission deadline 28 Nov 2025 | Viewed by 89 | Submission Open

Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation

(This special issue belongs to the Section Cardiology)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 Nov 2025 | Viewed by 87 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 Nov 2025 | Viewed by 79 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract

edited by

Adam Fabisiak

and Hubert Zatorski

submission deadline 28 Nov 2025 | Viewed by 65 | Submission Open

Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery

edited by

Pantelis Antonakis

and Konstantinos Bramis

submission deadline 28 Nov 2025 | Viewed by 53 | Submission Open

Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Challenges in Maternal-Fetal Medicine

edited by Marzena Laskowska

submission deadline 29 Nov 2025 | 6 articles | Viewed by 3946 | Submission Open

Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Critical Care Medicine

edited by Pietro Caironi

submission deadline 30 Nov 2025 | 11 articles | Viewed by 26063 | Submission Open

Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma

(This special issue belongs to the Section Intensive Care)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 30 Nov 2025 | 10 articles | Viewed by 8025 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in Cornea Transplantation

edited by Giulia Coco and Davide Romano

submission deadline 30 Nov 2025 | 6 articles | Viewed by 5198 | Submission Open

Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea

(This special issue belongs to the Section Ophthalmology)

Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era

edited by

Georgios I. Tagarakis

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4635 | Submission Open

Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology

(This special issue belongs to the Section Cardiovascular Medicine)

Maxillo-Facial Surgery: New Insights and Technologies in Head and Neck

edited by Federica Ruggiero

submission deadline 30 Nov 2025 | 6 articles | Viewed by 4223 | Submission Open

Keywords: oral and maxilla-facial surgery; orthognathic surgery; cranio-facial surgery; head and neck surgery; augmented reality; navigation; finite element modeling; virtual surgical planning; patient-specific implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Preventive, Diagnostic and Therapeutic Strategies for Abdominal Surgery Complications (Second Edition)

edited by

Orestis Ioannidis

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3880 | Submission Open

Keywords: complications; diagnosis; treatment; management; morbidity; abdomen; abdominal surgery; outcome; postoperative

(This special issue belongs to the Section General Surgery)

What’s New in Cardiomyopathies: Diagnosis, Treatment and Management

edited by

Cinzia Forleo

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3398 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases

(This special issue belongs to the Section Cardiology)

Clinical Advances in Therapy of Trauma and Surgical Critical Care

edited by Rabail Chaudhry and George W. Williams

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3259 | Submission Open

Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations

(This special issue belongs to the Section Intensive Care)

Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches

edited by Elisabeth M.J.P. Mouws and

Natasja de Groot

submission deadline 30 Nov 2025 | 4 articles | Viewed by 2943 | Submission Open

Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options

(This special issue belongs to the Section Cardiology)

Recent Progress in Rehabilitation Medicine—3rd Edition

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1122 | Submission Open

Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by Alfredo Papa and Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances of Breast Surgery and Reconstruction

edited by

Glenda Giorgia Caputo

and Emanuele Cigna

submission deadline 30 Nov 2025 | Viewed by 801 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Updates on Rheumatoid Arthritis: 2nd Edition

edited by Francesca Bandinelli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 733 | Submission Open

Keywords: rheumatoid arthritis; rheumatology; treatment; diagnosis; biomarkers; rheumatic disease

(This special issue belongs to the Section Immunology)

Innovative Technologies and Approaches in Eye Disease Management and Refractive Surgery

edited by

Hidenaga Kobashi

submission deadline 30 Nov 2025 | Viewed by 704 | Submission Open

Keywords: multifocal intraocular lenses; femtosecond lasers; artificial intelligence; imaging; eye surgery; refractive surgery

(This special issue belongs to the Section Ophthalmology)

Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities

edited by

Federico Gelpi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 694 | Submission Open

Keywords: head and neck oncology; free flaps; oral surgery; malformative surgery; traumatology; endoscopy; preprosthetic surgery; reconstructive surgery; vascular malformations; osteonecrosis

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 30 Nov 2025 | 1 articles | Viewed by 508 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thoracic Surgery Between Tradition and Innovations

edited by Jacopo Vannucci

submission deadline 30 Nov 2025 | 1 articles | Viewed by 498 | Submission Open

Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy

(This special issue belongs to the Section General Surgery)

Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition

edited by Nikos Nikolettos and

Angeliki Tiptiri-Kourpeti

submission deadline 30 Nov 2025 | 1 articles | Viewed by 421 | Submission Open

Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 30 Nov 2025 | 1 articles | Viewed by 413 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 1 articles | Viewed by 360 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 30 Nov 2025 | 1 articles | Viewed by 344 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Clinical Updates on Prosthodontics

edited by

Rubén Agustín Panadero

and Carla Fons-Badal

submission deadline 30 Nov 2025 | Viewed by 286 | Submission Open

Keywords: dental prosthesis; dental implants; gingival treatment; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 30 Nov 2025 | Viewed by 198 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases

edited by Sotiria Palioura, Carolina L. Mercado and

Jaime D. Martinez

submission deadline 30 Nov 2025 | Viewed by 171 | Submission Open

Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques

(This special issue belongs to the Section Ophthalmology)

Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care

edited by

Keiichi Hirono

submission deadline 30 Nov 2025 | Viewed by 162 | Submission Open

Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging

(This special issue belongs to the Section Cardiology)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 30 Nov 2025 | Viewed by 143 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Current Challenges in Orthopedic Trauma Surgery

edited by Pietro Maniscalco and Fabrizio Quattrini

submission deadline 30 Nov 2025 | Viewed by 130 | Submission Open

Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations

(This special issue belongs to the Section Orthopedics)

Displaying special issue 851-900 on page 18 of 28.

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