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Advances in Clinical Exercise for Health
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Advances in Clinical Exercise for Health

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Sports Medicine".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 525

Special Issue Editors

Dr. Pedro Miguel Forte

E-Mail Website
Guest Editor
1. Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal
2. Research Center for Active Living and Wellbeing (LiveWell), Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
3. Department of Sports, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
4. CI-ISCE, ISCE Douro, 4560-708 Penafiel, Portugal
Interests: chronic pain; physical exercise; sports science
Special Issues, Collections and Topics in MDPI journals
Dr. Joana Ribeiro

E-Mail Website
Guest Editor Assistant
Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal
Interests: physical exercise; sports science; psychology

Special Issue Information

Dear Colleagues,

Physical activity and structured exercise are essential components in the promotion of health, the prevention of chronic diseases, and the enhancement of physical and mental well-being. Increasing evidence highlights the effectiveness of exercise interventions across diverse populations, from athletes to individuals with chronic health conditions. Clinical exercise science offers a multidisciplinary approach that integrates assessment tools, biomechanical analysis, and personalized exercise prescription to optimize both health outcomes and performance.

This Special Issue aims to explore the intersection of physical activity, clinical assessment, and real-world health applications. We welcome contributions that investigate the role of exercise in improving cardiovascular and metabolic health, preventing and managing noncommunicable diseases, supporting healthy aging, enhancing immune function, and reducing the incidence of sports-related injuries. Special emphasis will be given to translational and interdisciplinary research that bridges the gap between scientific findings and clinical or community-based interventions.

Topics of interest include, but are not limited to, the following:

  • Clinical assessment protocols and biomechanical tools in exercise science;
  • Exercise interventions for chronic disease prevention and management;
  • Exercise for mental health, quality of life, and healthy aging;
  • Innovations in exercise prescription and testing models;
  • Integrative approaches combining exercise with other health disciplines;
  • Physical activity strategies to enhance sports performance and reduce injury risk.

By bringing together novel research and applied methodologies, this Special Issue seeks to contribute to the development of effective strategies that can inform clinical practice.

Dr. Pedro Miguel Forte
Guest Editor

Dr. Joana Ribeiro
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical exercise science
  • physical activity
  • chronic disease prevention
  • biomechanics
  • healthy aging
  • physiology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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15 pages, 747 KB  
Article
Blood Flow Restriction Training Improves Cardiac Structure and Diastolic Function in Runners with Exercise-Induced Hypertension
by Young-Joo Kim, Jong-Young Lee, Choung-Hwa Park and Han-Soo Park
J. Clin. Med. 2025, 14(21), 7795; https://doi.org/10.3390/jcm14217795 (registering DOI) - 3 Nov 2025
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Abstract
Background/Objectives: Exercise-induced hypertension (EIH) in runners predisposes them to cardiovascular diseases, including myocardial hypertrophy, arrhythmias, and coronary artery disease. Blood flow restriction (BFR) training has been reported to exert non-pharmacological benefits in runners with EIH by improving blood pressure, myocardial workload, and [...] Read more.
Background/Objectives: Exercise-induced hypertension (EIH) in runners predisposes them to cardiovascular diseases, including myocardial hypertrophy, arrhythmias, and coronary artery disease. Blood flow restriction (BFR) training has been reported to exert non-pharmacological benefits in runners with EIH by improving blood pressure, myocardial workload, and cardiorespiratory fitness. The purpose of this study was to investigate whether changes in myocardial structure and function accompany these effects of BFR training in middle-aged runners with EIH. Methods: Participants who exhibited a maximal systolic blood pressure of ≥210 mmHg during an exercise stress test were assigned either to a BFR training group (BFRTg, n = 15) or to a control group without BFR training (non-BFRTg, n = 14). The BFRTg underwent a two-month BFR training program, performed twice per week for 20 min per session. Cardiac structure and function were evaluated before and after the intervention, and exercise stress test data were obtained from secondary sources of a previous study. Results: Compared with controls, the BFR group showed lower maximal exercise SBP, longer exercise duration, and higher VO2max. Echocardiography revealed reduced interventricular septal thickness and improved diastolic indices (higher E′/A′, lower E/E′), while systolic function remained unchanged. Conclusions: In conclusion, reductions in septal thickness and improvements in diastolic function induced by blood flow restriction training in runners with exercise-induced hypertension suggest a favorable cardiac adaptation, accompanied by concurrent improvements in exercise blood pressure and cardiorespiratory fitness. Full article
(This article belongs to the Special Issue Advances in Clinical Exercise for Health)
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19 pages, 1884 KB  
Systematic Review
Fit Hearts, Better Outcomes? A Systematic Review and Meta-Analysis of Exercise Intensity and Peak VO2 in Hypertrophic Cardiomyopathy
by Andrija Djuranovic, Jovana Ristic, Milena Antic, Nina Rajovic, Mladen Mirkovic, Djordje Batinic, Milos Maletic, Sevda Ece Kizilkilic, Victoria Zecchin Ferrara, Verica Prodanovic, Suzana Savic, Sanja Mazic and Natasa Milic
J. Clin. Med. 2025, 14(21), 7466; https://doi.org/10.3390/jcm14217466 - 22 Oct 2025
Viewed by 343
Abstract
Background: This study aimed to systematically review and analyze the available evidence on the safety and efficacy of physical activity (PA) in patients with HCM. Methods: We conducted a systematic search of PubMed, Cochrane, and Web of Science databases up to March 30, [...] Read more.
Background: This study aimed to systematically review and analyze the available evidence on the safety and efficacy of physical activity (PA) in patients with HCM. Methods: We conducted a systematic search of PubMed, Cochrane, and Web of Science databases up to March 30, 2025. Fourteen studies (4 RCTs) were included in the qualitative synthesis and ten in the quantitative synthesis, totaling 10478 patients. Results: The meta-analysis demonstrated a significant improvement in peak VO2 in the moderate intensity PA (MIPA) group, with a mean difference of 1.77 mL/kg/min (95% CI: 0.93 to 2.60, I2 = 38.2%, p = 0.19), while changes in body mass index were not significant (MD: −0.66 kg/m2; 95% CI: −1.77 to 0.44; I2 = 62%; p = 0.07). No significant differences were observed in the occurrence of non-sustained ventricular tachycardia (NSVT) (OR = 1.54, 95% CI: 0.93 to 2.52, I2 = 28.3%, p = 0.24), atrial fibrillation (OR = 0.89, 95% CI: 0.77 to 1.03, I2 = 28.6%, p = 0.23), or syncope (OR = 1.23, 95% CI: 0.72 to 2.10, I2 = 25.6%, p = 0.24) between the MIPA and sedentary group. Additionally, the occurrence of NSVT between the high-intensity PA and MIPA group showed no significant difference (OR = 1.19, 95% CI: 0.60 to 2.36, I2 = 0%, p = 0.99). Conclusion: The results suggest that regular exercise does not increase the risk of NSVT, AF, or syncope while enhancing peak VO2, indicating that regular exercise is safe and beneficial in HCM patients. Full article
(This article belongs to the Special Issue Advances in Clinical Exercise for Health)
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