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Clinical Advances in Autism Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 146

Special Issue Editor


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Guest Editor
Institute of Physiotherapy, Faculty of Health Sciences and Psychology, Medical College, University of Rzeszów, 35-959 Rzeszów, Poland
Interests: autism spectrum disorder; ADHD; intellectual disability; neurodysfunction; neurorehabilitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by challenges in social interaction and communication, as well as restricted, repetitive patterns of behavior, interests, or activities. These core features vary widely in severity and presentation across individuals, making the "spectrum" nature of the disorder a key defining trait—ranging from those needing significant support to others who may function independently with targeted interventions.

Current interventions for ASD are multifaceted; pharmacological treatments, for example, may address co-occurring conditions such as anxiety, hyperactivity, or sleep disturbances.

This Special Issue invites original research exploring ASD’s diverse manifestations, underlying mechanisms, innovative therapeutic strategies, and frequent comorbidities—including gastrointestinal issues, epilepsy, and mental health disorders—to advance understanding and improve outcomes for individuals across the spectrum. 

Dr. Justyna Podgórska-Bednarz
Guest Editor

Manuscript Submission Information

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Keywords

  • autism spectrum disorder
  • diagnosis
  • child
  • adult
  • youth
  • early intervention
  • therapy
  • epidemiology
  • relatives
  • resources
  • limitations
  • problems
  • health
  • epidemiology
  • perspectives
  • organization

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Published Papers (1 paper)

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Research

13 pages, 699 KB  
Article
Targeted Endogenous Bioelectric Modulation in Autism Spectrum Disorder: Real-World Clinical Outcomes of the REAC BWO Neurodevelopment–Autism Protocol
by Arianna Rinaldi, Hingrid Angélica Benetti Mota, Salvatore Rinaldi and Vania Fontani
J. Clin. Med. 2025, 14(21), 7500; https://doi.org/10.3390/jcm14217500 - 23 Oct 2025
Viewed by 33
Abstract
Background: Autism Spectrum Disorder (ASD) is characterized by atypical brain oscillatory dynamics and altered connectivity, impairing sensory integration, socio-communicative responsiveness, and behavioral regulation. Methods: Radio Electric Asymmetric Conveyer (REAC) technology delivers non-invasive neurobiological modulation through standardized, operator-independent protocols. The Brain Wave Optimization [...] Read more.
Background: Autism Spectrum Disorder (ASD) is characterized by atypical brain oscillatory dynamics and altered connectivity, impairing sensory integration, socio-communicative responsiveness, and behavioral regulation. Methods: Radio Electric Asymmetric Conveyer (REAC) technology delivers non-invasive neurobiological modulation through standardized, operator-independent protocols. The Brain Wave Optimization Neurodevelopment–Autism (BWO ND-A) protocol was designed to address oscillatory patterns frequently altered in ASD, aiming to promote network coherence and multidomain functional improvement. This retrospective pre–post single-arm study evaluated 39 children with ASD (31 males, 8 females; mean age 7.85 ± 2.90 years). All received one Neuro Postural Optimization (NPO) session to prime central nervous system adaptive capacity, followed by BWO ND-A (18 sessions, ~8 min each), administered 3–4 times daily over ~two weeks. The primary outcome was the Autism Treatment Evaluation Checklist (ATEC) total score; secondary outcomes were its four subscales. Results: Mean total ATEC decreased from 67.76 ± 16.11 to 56.25 ± 23.66 (mean change −11.51 ± 14.48; p < 0.0001; Cohen’s dz = 0.78). Clinically meaningful improvement (≥8-point reduction) occurred in 59% of participants. In 10.3% of cases, caregiver ratings indicated an apparent worsening (≥8-point increase). However, no objective deterioration or adverse effects were observed. This pattern was most likely related to a transient phase of functional re-adaptation, during which emerging changes may initially be perceived by caregivers as worsening before stabilizing into improvement. Conclusions: While these findings suggest promising short-term real-world efficacy and safety, the absence of a control group, lack of objective neurophysiological measures, and no long-term follow-up limit causal inference. Future controlled studies with neurophysiological monitoring are needed to confirm the targeted neuromodulatory action and durability of effects. Full article
(This article belongs to the Special Issue Clinical Advances in Autism Management)
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