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Clinical Advances in Musculoskeletal Disorders: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Rehabilitation".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 1333

Special Issue Editors


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Guest Editor
Academic Department of Trauma & Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK
Interests: pelvic instability; pelvic reconstruction; non-union; bone regeneration; post fracture fixation complications
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Academic Department of Trauma & Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK
2. Centre for Joint Reconstruction Surgery, Sushrut Institute of Medical Sciences, Nagpur, India
Interests: musculoskeletal disorders; orthopedic surgery; traumatology; reconsturuction surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue entitled “Clinical Advances in Musculoskeletal Disorders: 2nd Edition”. This is a new volume, with 10 papers published in the first volume. For more details, please visit https://www.mdpi.com/journal/jcm/special_issues/X2NY6KBAV0.

Musculoskeletal disorders encompass various clinical conditions that affect the human musculoskeletal system. Bones, joints, muscles, tendons, ligaments, nerves, and connective tissues can all be afflicted, leading to pain, tenderness, inflammation, swelling, muscle spasm, and functional restrictions.

Overall, these conditions may be caused by hereditary, congenital, or acquired pathological developments. Inflammatory, infectious, degenerative, traumatic, vascular, metabolic, and neoplastic processes can lead to various types of impairment and degrees of severity. The three most prevalent musculoskeletal conditions known to be associated with the greatest number of health care-related visits to emergency departments and hospitals are trauma, backache, and arthritis.

Musculoskeletal disorders of traumatic origin develop due to a sudden intensity (i.e., lifting a heavy object) or due to the repeated exposure to force, vibration, or an awkward posture. They can affect any part of the body, including the upper extremities, hands, neck, spine, pelvis, lower extremities, and feet.

The most popular diagnostic tests employed to screen and diagnose musculoskeletal disorders include radiographs, computed tomography, magnetic resonance, and ultrasonography.

Musculoskeletal disorders represent the second most prevalent cause of disability globally; this is measured in terms of the number of years those affected live with disability and the fact that it continues to be a burden on society as a whole, due to the enormous direct costs to the health care system it incurs and the indirect costs  suffered due to the loss of work. As the global population ages, it is envisaged that the number of people suffering from musculoskeletal conditions will also increase. Currently, the global prevalence of MSDs is reported to be as high as 40%.

In this Special Issue, we invite authors to submit their research work on this important topic. Papers focusing on epidemiological studies, diagnostic techniques, novel treatment modalities, either surgical, non-invasive, or non-operative, rehabilitation protocols, and patient-reported outcomes are all welcome; this is with the aim of enhancing our knowledge and providing further insight into these ever-growing disabling and costly conditions.

Prof. Dr. Peter V. Giannoudis
Prof. Dr. Sushrut Babhulkar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • musculoskeletal disorders
  • disability
  • pain
  • inflammation
  • arthritis

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Related Special Issue

Published Papers (3 papers)

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Research

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13 pages, 1304 KB  
Article
Characterizing Biomarkers of Muscle Damage in Collegiate Football Players: A Prospective, Repeated Measures Study
by Grace Brandhurst, Erik Piedy, Stephen Etheredge, Matthew Martone, Heather D. Quiriarte, Paul Phillips IV, Derek Calvert, Nathan P. Lemoine, Jr., Jack Marucci, Brian A. Irving, Robert Zura, Guillaume Spielmann, Neil M. Johannsen and Rachel Matthews
J. Clin. Med. 2026, 15(7), 2502; https://doi.org/10.3390/jcm15072502 - 25 Mar 2026
Viewed by 48
Abstract
Background/Objectives: Exertional rhabdomyolysis (ER) is a possibly fatal condition resulting from extreme or novel exercise that causes substantial muscle breakdown. ER has been observed during preseason football; however, prospective research has yet to characterize normal versus ER responses using a repeated measures design. [...] Read more.
Background/Objectives: Exertional rhabdomyolysis (ER) is a possibly fatal condition resulting from extreme or novel exercise that causes substantial muscle breakdown. ER has been observed during preseason football; however, prospective research has yet to characterize normal versus ER responses using a repeated measures design. This study characterized ER biomarker responses related to muscle damage, and renal and hepatic stress, after two NCAA Division I preseason football scrimmages. Methods: Following a prospective, repeated measures design, blood and urine samples from 17 players were collected immediately (IPS) and 24 h post-scrimmage (24hPS). A subset (n = 13) provided samples after 48 h of rest as a non-exertion (NE) comparator group. A Comprehensive Metabolic Panel was run on serum samples, and urine samples were analyzed for myoglobin and creatinine. Values were compared with reference ranges, mixed models evaluated time effects, and linear regressions examined associations between CPK and renal and hepatic biomarkers. Results: No participants were diagnosed with ER. A time effect was observed for CPK (p < 0.01), with CPK greater IPS (991.6 ± 560.8 IU/L) compared to NE (267.7 ± 205.3 IU/L), and remaining elevated above reference ranges at 24hPS (739.2 ± 442.6 IU/L). Similar time effects were observed with LDH, AST, and ALT (p < 0.01). Serum creatinine increased above reference values and NE concentrations (p < 0.01). CPK correlated (p < 0.01 for all) with LDH (r = 0.69), serum myoglobin (r = 0.57), creatinine (r = 0.42), AST (r = 0.77), and ALT (r = 0.38). Conclusions: Biomarkers of muscle damage, renal stress, and liver function were higher IPS, with only partial recovery by 24hPS. These findings provide preliminary reference patterns for biomarker fluctuations and support individualized, serial monitoring to identify abnormal responses and promote early detection of ER. Full article
(This article belongs to the Special Issue Clinical Advances in Musculoskeletal Disorders: 2nd Edition)
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39 pages, 13943 KB  
Article
Characterizing Initial Cervical Spine and Neurovascular Findings in 84 Consecutive Patients with Hypermobile Ehlers–Danlos Syndrome: A Retrospective Study
by Ross A. Hauser, Morgan Griffiths, Ashley Watterson, Danielle Matias and Benjamin R. Rawlings
J. Clin. Med. 2026, 15(6), 2212; https://doi.org/10.3390/jcm15062212 - 14 Mar 2026
Viewed by 374
Abstract
Background: Hypermobile Ehlers–Danlos syndrome (hEDS) can present as a complex interplay of widespread symptomatology and multisystem involvement, posing diagnostic and treatment challenges. Objective characterization of cervical spine and neurovascular findings in hEDS has been limited. Previous studies have emphasized upper cervical spine [...] Read more.
Background: Hypermobile Ehlers–Danlos syndrome (hEDS) can present as a complex interplay of widespread symptomatology and multisystem involvement, posing diagnostic and treatment challenges. Objective characterization of cervical spine and neurovascular findings in hEDS has been limited. Previous studies have emphasized upper cervical spine complications in hEDS, yet the relevance and mechanisms underlying associated symptomatology have not been elucidated. This study examined objective test findings in patients with hEDS at an outpatient neck clinic to explore cervical spine and neurovascular pathology that could contribute to further understanding the clinical profile of a subset of patients with hEDS. Methods: This single-center, retrospective observational study included patients with hEDS aged 20–50 years from 1 January 2022–31 December 2024, at an outpatient neck center. It excluded previous neck surgery, traumatic events, or related injury. Demographic, clinical, and diagnostic data were collected through a retrospective chart review, including measurements from standard clinical diagnostic protocols: digital motion X-ray (videofluoroscopy), cone beam CT, Doppler ultrasound, and tonometry. Results: More than 71% of patients reported ≥29 symptoms. Nearly all patients exhibited co-occurring forward head, decreased depth of curve, ligamentous cervical instability, and decreased internal jugular vein (IJV) and vagus nerve cross-sectional area (CSA). Vagus nerve CSA was found to be significantly smaller than the comparative healthy/normal population. IJV CSA was significantly smaller at C1 than at C4–C5, suggesting evidence of carotid sheath compression at C1. Conclusions: This study offers novel evidence that cervical spine pathology, IJV compression, and vagus nerve degeneration are uniformly prevalent in hEDS, which may contribute to, or be an etiological basis for, the multisystem involvement in a subset of patients with this disorder. These findings provide hypothesis-generating data to inform future mechanistic and therapeutic studies, including exploration of new diagnostic and treatment targets. Full article
(This article belongs to the Special Issue Clinical Advances in Musculoskeletal Disorders: 2nd Edition)
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Review

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18 pages, 681 KB  
Review
Metabolic Myopathies and HyperCKemia in Adulthood: A Clinical Approach to Diagnosis and Management
by Loai A. Shakerdi
J. Clin. Med. 2026, 15(5), 2070; https://doi.org/10.3390/jcm15052070 - 9 Mar 2026
Viewed by 382
Abstract
Background: HyperCKemia, defined as elevated serum creatine kinase, commonly reflects muscle injury but may also indicate underlying metabolic disease. Metabolic aetiologies, including glycogen storage disorders, fatty acid oxidation defects, mitochondrial cytopathies, and purine metabolism disorders, are clinically important owing to diagnostic complexity, therapeutic [...] Read more.
Background: HyperCKemia, defined as elevated serum creatine kinase, commonly reflects muscle injury but may also indicate underlying metabolic disease. Metabolic aetiologies, including glycogen storage disorders, fatty acid oxidation defects, mitochondrial cytopathies, and purine metabolism disorders, are clinically important owing to diagnostic complexity, therapeutic implications, and potential reversibility. Objective: To summarise current evidence on metabolic causes of hyperCKemia in adults, with emphasis on disorders of carbohydrate, lipid, and purine metabolism and mitochondrial disease. Methods: Semi-systematic narrative review of pathophysiology, clinical features, diagnostic approaches, and management of metabolic disorders associated with hyperCKemia. Results: Metabolic myopathies often present with nonspecific or exercise-related symptoms, with creatine kinase levels ranging from mild-to-severe elevations. Conditions such as McArdle disease, carnitine palmitoyltransferase II deficiency, and mitochondrial cytopathies demonstrate characteristic metabolic vulnerabilities leading to episodic or persistent hyperCKemia. Medications, including statins and antiretrovirals, may precipitate symptoms in predisposed individuals. Diagnosis requires a structured, multidisciplinary approach incorporating biochemical testing, genetic analysis, functional studies, and muscle biopsy. Many causes are amenable to targeted therapy, including dietary modification, endocrine correction, and medication withdrawal. Conclusion: Metabolic causes of hyperCKemia are under-recognised but clinically significant. Early identification allows targeted treatment and prevention of complications. Full article
(This article belongs to the Special Issue Clinical Advances in Musculoskeletal Disorders: 2nd Edition)
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