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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 31 Jan 2026 | Viewed by 279 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Application of Artificial Intelligence in Gastric Cancer

edited by

Lorena Torroni

and

Maria Bencivenga

submission deadline 31 Jan 2026 | Viewed by 232 | Submission Open

Keywords: artificial intelligence (AI); gastric cancer; AI-assisted endoscopy; radiomics; robotic surgery; gastrointestinal diseases; digital pathology; translational research; innovation in healthcare

(This special issue belongs to the Section Oncology)

Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care

edited by

Konstantinos Stathogiannis

submission deadline 31 Jan 2026 | Viewed by 158 | Submission Open

Keywords: TAVI; TAVR; MTEER; TTEER; TTVR; ASD; PFO; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Clinical Management and Update of Aortic Dissection and Aortic Aneurysm Diseases

edited by

Makoto Hibino

submission deadline 31 Jan 2026 | Viewed by 133 | Submission Open

Keywords: aortic aneurysm; aortic dissection; aortic surgery; endovascular procedures

(This special issue belongs to the Section Cardiovascular Medicine)

Anesthesia and Pain Management for Women: 2nd Edition

edited by Gaetano Draisci and Stefano Catarci

submission deadline 31 Jan 2026 | Viewed by 117 | Submission Open

Keywords: anesthesia; women; gender differences; acute pain; chronic pain; hormonitoring; pain perception; fibromyalgia; migraine; monitoring; obstetrics; cesarean section; gynecologic surgery

(This special issue belongs to the Section Anesthesiology)

Strategies to Optimize Efficiency of Clear Aligners and Fixed Appliances in the Digital Orthodontics Era

edited by

Maciej Jedliński

submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open

Keywords: clear aligners; fixed orthodontic appliances; digital orthodontics; orthodontic treatment planning; tooth movement efficiency; patient-centered care; treatment modality selection

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition

edited by Senthil Sambandam

submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open

Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening

(This special issue belongs to the Section Orthopedics)

Update on Acute Severe Respiratory Infections: 2nd Edition

edited by

Jean-Francois Timsit

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation

(This special issue belongs to the Section Respiratory Medicine)

Skin Cancer: From Diagnosis to Personalized Treatment

edited by

Anthony J. Dixon

submission deadline 31 Jan 2026 | Viewed by 81 | Submission Open

Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery

(This special issue belongs to the Section Dermatology)

Exercise, Injury and Rehabilitation: Integrated Perspectives in Sports Medicine

edited by

Cíntia França

and

Élvio Gouveia

submission deadline 3 Feb 2026 | 2 articles | Viewed by 1691 | Submission Open

Keywords: sports medicine; biomechanics; injury prevention; exercise physiology; sports performance; load management; exercise prescription; return to play; recovery

(This special issue belongs to the Section Sports Medicine)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) as a Global but Not Liver-Limited Health Challenge—from Disease Pathogenesis to Therapeutic Targets

edited by

Beata Kasztelan-Szczerbinska

and Halina Cichoż-Lach

submission deadline 5 Feb 2026 | 4 articles | Viewed by 8381 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); non-alcoholic fatty liver disease (NAFLD); hepatic steatosis; multiorgan metabolic interactions; liver-related morbidity; liver-related mortality; lipid metabolism; cardiovascular metabolic complications; metabolic dysfunction-related cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances and Clinical Outcomes of Cardiothoracic Surgery

edited by Hee-Jung Kim and

Seung-Hyun Lee

submission deadline 5 Feb 2026 | Viewed by 130 | Submission Open

Keywords: cardiac surgery; coronary artery bypass grafting; heart valve surgery; aortic intervention; materials; precision medicine; artificial intelligence

(This special issue belongs to the Section General Surgery)

Physical Therapy in Neurorehabilitation: Innovations, Challenges and Opportunities

edited by

Daphne Bakalidou

Maria Gabriella Ceravolo

and

Pinelopi Vlotinou

submission deadline 6 Feb 2026 | Viewed by 118 | Submission Open

Keywords: neurorehabilitation; physical activity; neurocognitive rehabilitation; neurogenic bladder; fatigue; sexual dysfunction; accessibility

(This special issue belongs to the Section Clinical Neurology)

Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era, 3rd Edition

edited by

Adolfo Di Fiore

and

Giulia Brunello

submission deadline 10 Feb 2026 | 5 articles | Viewed by 14409 | Submission Open

Keywords: 3D printing; additive manufacturing; milling technologies; CAD/CAM; digital implant planning; digital workflow; facial scanners; computer-guided implant surgery; intraoral scanners; digital design and fabrication of dental prostheses

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates and Perspectives of Implant Dentistry

edited by

Renzo Guarnieri

and

Rodolfo Reda

submission deadline 10 Feb 2026 | 4 articles | Viewed by 10367 | Submission Open

Keywords: osseointegration; soft tissue integration; peri-implant diseases

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | 2 articles | Viewed by 4412 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section Infectious Diseases)

The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition

edited by

Winfried Schlee

and

Jorge Piano Simões

submission deadline 10 Feb 2026 | 3 articles | Viewed by 3535 | Submission Open

Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data

(This special issue belongs to the Section Otolaryngology)

Current Challenges and Advancements in Lateral Skull Base Surgery

edited by Alessia Rubini

submission deadline 10 Feb 2026 | 2 articles | Viewed by 2171 | Submission Open

Keywords: lateral skull base; neurotology; jugular foramen; cerebellopontine angle; petrous apex; inner ear; acoustic neuroma; jugular paraganglioma; transtemporal approaches; infratemporal approaches

(This special issue belongs to the Section Otolaryngology)

Plastic and Reconstructive Surgery: Cutting-Edge Expert Perspective

edited by

Roberto Cuomo

and

Ishith Seth

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1953 | Submission Open

Keywords: plastic and reconstructive surgery; new perspectives; regeneration; microsurgery; oncoplastic; post bariatric; breast implant

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Application of Anticoagulation and Antiplatelet Therapy

edited by

Rossella Marcucci

and

Martina Berteotti

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1377 | Submission Open

Keywords: antiplatelets; anticoagulants; atherothrombosis; coronary artery disease; peripheral artery disease; cerebral artery disease; vitamin K antagonists; direct oral anticoagulants; clopidogrel; aspirin; ticagrelor; prasugrel

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Pediatric Critical Care Medicine

edited by

Lama Elbahlawan

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1225 | Submission Open

Keywords: acute renal failure; acute respiratory failure; pediatric oncology; pediatric ICU; pediatric critical care medicine; multi-organ dysfunction

(This special issue belongs to the Section Clinical Pediatrics)

Advancements and Future Directions in Clinical Psychosis

edited by

Marco Colizzi

and

Alessandra Martinelli

submission deadline 10 Feb 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innova-tive diagnostic tools

(This special issue belongs to the Section Mental Health)

Management of Congenital Heart Disease (CHD)

edited by Sarah Nordmeyer and Marie Schafstedde

submission deadline 10 Feb 2026 | 1 articles | Viewed by 483 | Submission Open

Keywords: congenital heart disease; imaging; diagnostics; surgical innovations; minimally invasive interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence

edited by

Massimiliano Creta

submission deadline 10 Feb 2026 | Viewed by 224 | Submission Open

Keywords: extracorporeal shock wave lithotripsy; lasers; percutaneous lithotripsy; robotic surgery; ureteroscopy; urolithiasis

(This special issue belongs to the Section Nephrology & Urology)

Hearing Disorders: Diagnosis, Management, and Future Opportunities: 4th Edition

edited by

George K. Psillas

submission deadline 10 Feb 2026 | Viewed by 140 | Submission Open

Keywords: middle ear surgery; otosclerosis; sensorineural hearing loss; sudden hearing; cochlear implant

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in Spine Disorders—2nd Edition

edited by

Sokol Trungu

and

Luca Ricciardi

submission deadline 10 Feb 2026 | Viewed by 117 | Submission Open

Keywords: spine disorders; lumbar spine surgery; minimally invasive surgery; spine surgery; microneurosurgery

(This special issue belongs to the Section Clinical Neurology)

Recent Concepts in Ovarian Cancer: Epidemiology, Diagnosis, Treatment and Quality of Life

edited by Giulia Scotto and

Giorgio Valabrega

submission deadline 10 Feb 2026 | Viewed by 110 | Submission Open

Keywords: ovarian cancer; quality of life; multidisciplinary care; personalized medicine; PARP inhibitors

(This special issue belongs to the Section Oncology)

Clinical Advances in Pain Management

edited by Jamal Hasoon and Omar Viswanath

submission deadline 13 Feb 2026 | 11 articles | Viewed by 15942 | Submission Open

Keywords: postoperative pain; acute pain; chronic pain; nociceptive; analgesia; analgesics; interventional pain procedures

(This special issue belongs to the Section Anesthesiology)

Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations

edited by Giuseppe Barilaro

submission deadline 15 Feb 2026 | 4 articles | Viewed by 4209 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Periodontal Diseases and Systemic Health: Pathogenesis, Prevention and Management

edited by Saverio Cosola

submission deadline 15 Feb 2026 | 2 articles | Viewed by 3145 | Submission Open

Keywords: periodontitis; dental implants; systemic inflammation; diabetes and periodontal disease; cardiovascular implications; pregnancy and oral health; host immune responses; preventive dentistry; implant-prosthetic rehabilitation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances

edited by Cristian George Ţieranu and

Adrian Saftoiu

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2903 | Submission Open

Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiac Electrophysiology: Focus on Clinical Practice

edited by

Andreas Müssigbrodt

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2239 | Submission Open

Keywords: cardiomyopathy; arrhythmia; heart rhythm; atrial fibrillation; ventricular tachycardia; sudden cardiac death; mapping; ablation; pulsed field ablation (PFA); device; pacemaker; left bundle branch area pacing (LBBAP); conduction system pacing (CSP); implantable cardioverter-defibrillator (ICD); leadless pacing; extraction

(This special issue belongs to the Section Cardiology)

Current Concepts and Updates in Eye Diseases

edited by Wiktor Stopyra,

Joanna Konopińska

and Anna Machalinski

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1889 | Submission Open

Keywords: corneal disease; glaucoma; cataract; uveitis; ocular oncology; retinal disorder; ocular treatment; eye surgery; ocular diagnostics

(This special issue belongs to the Section Ophthalmology)

Bariatric Surgery: Challenges and Future Trends

edited by Hugo Santos-Sousa

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1484 | Submission Open

Keywords: obesity; metabolic and bariatric surgery; sleeve gastrectomy; metabolic syndrome; novel surgical procedures; Nissen-sleeve fundoplication; Roux-en-Y gastric bypass distalization; single-anastomosis procedures

(This special issue belongs to the Section General Surgery)

New Insight into Pain and Chronic Pain Management

edited by

Eung Don Kim

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: chronic pain; pain management; pharmacological treatment; non-pharmacological interventions; neuromodula-tion; multidisciplinary approaches; personalized medicine; quality of life

(This special issue belongs to the Section Clinical Rehabilitation)

Catheter Ablation of Cardiac Arrhythmias: Current Updates and Perspectives: 2nd Edition

edited by

Shaojie Chen

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1413 | Submission Open

Keywords: ablation; arrhythmia; electrophysiology; atrial fibrillation; atrial flutter; atrial tachycardia; mapping; supraventricular tachycardia; ventricular arrhythmia

(This special issue belongs to the Section Cardiology)

Drug-Related Problems: Clinical Pharmacy and Safety of Pharmacotherapy

edited by

Mariola Drozd

and

Jakub Pawlikowski

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1377 | Submission Open

Keywords: adverse drug reaction; drug-related problems; drug formulation technology; safety of pharmacotherapy; clinical pharmacy; pharmaceutical care; pharmacology

(This special issue belongs to the Section Pharmacology)

New Insights in Neonatal Intensive Care

edited by

Benjamim Ficial

Leonardo Gottin

and Martina Ciarcià

submission deadline 15 Feb 2026 | Viewed by 777 | Submission Open

Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine

(This special issue belongs to the Section Clinical Pediatrics)

Advances in Traumatic Brain Injury: Causes and Recovery

edited by Antonio Bonora

submission deadline 15 Feb 2026 | Viewed by 248 | Submission Open

Keywords: mild traumatic brain injury; TBI; brain injuries; neuroimaging; rehabilitation

(This special issue belongs to the Section Brain Injury)

Kidney Transplantation: Current Challenges and Future Perspectives: 2nd Edition

edited by Alberto Piana and Angelo Territo

submission deadline 15 Feb 2026 | Viewed by 164 | Submission Open

Keywords: kidney transplantation; urologic cancers; organ preservation; surgical challenges; donor selection; long-term outcomes; complications; post-transplant care; technology

(This special issue belongs to the Section Nephrology & Urology)

Recent Advances in Refractive Surgery and Intraocular Lens Implantation

edited by Antonio Leccisotti

submission deadline 15 Feb 2026 | Viewed by 157 | Submission Open

Keywords: refractive surgery; intraocular lens implantation; keratectomy; cornea; ocular surgery; optical coherence tomography; laser surgery; KLEx (keratorefractive lenticule extraction); femtolasik

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition

edited by

Eleonora M.C. Trecca

and

Andrea Albera

submission deadline 15 Feb 2026 | Viewed by 115 | Submission Open

Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Meniè re’ s disease; hearing loss; robotic surgery; oto-sclerosis

(This special issue belongs to the Section Otolaryngology)

State of the Art in Bladder Cancer: Diagnostics and Treatment Strategies

edited by

Angelo Porreca

submission deadline 15 Feb 2026 | Viewed by 101 | Submission Open

Keywords: bladder cancer; photodynamic diagnosis (PDD); bladder-sparing strategies; robotic-assisted surgery; single-port robotic cystectomy; older patients; immunotherapy; intravesical therapy; bladder preservation; minimally invasive urology; advanced bladder cancer; diagnostic innovation

(This special issue belongs to the Section Nephrology & Urology)

Clinical Perspectives in Amyotrophic Lateral Sclerosis: Diagnosis, Management and Future Opportunities

edited by

Matthias Boentert

submission deadline 15 Feb 2026 | Viewed by 97 | Submission Open

Keywords: amyotrophic lateral sclerosis; early diagnosis; neuroimaging; biomarkers; treatment

(This special issue belongs to the Section Clinical Neurology)

Eosinophilic Esophagitis: Clinical Advances in Diagnosis, Treatment, and Monitoring

edited by Pierfrancesco Visaggi, Edoardo Vincenzo Savarino and

Nicola De Bortoli

submission deadline 18 Feb 2026 | 4 articles | Viewed by 5434 | Submission Open

Keywords: eosinophilic esophagitis (EoE); diagnosis ; treatment ; monitoring; disease assessment; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition

edited by

Mariarita Tarallo

Enrico Fiori

and Marco Bononi

submission deadline 18 Feb 2026 | 4 articles | Viewed by 4984 | Submission Open

Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men

(This special issue belongs to the Section Endocrinology & Metabolism)

Traumatic Brain Injury: Emergency Management, Prevention of Secondary Injury, and Rehabilitation

edited by

Katja E. Wartenberg

and Lori Shutter

submission deadline 20 Feb 2026 | 5 articles | Viewed by 17989 | Submission Open

Keywords: traumatic brain injury; neuromonitoring; neurocritical care; neurorehabilitation; secondary injury; outcome; prognostication

(This special issue belongs to the Section Brain Injury)

Sepsis: Current Updates and Perspectives

edited by

Ecaterina Scarlatescu

submission deadline 20 Feb 2026 | 8 articles | Viewed by 17769 | Submission Open

Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies

(This special issue belongs to the Section Intensive Care)

Recent Developments in Gynecological Endocrinology

edited by

Błażej Męczekalski

submission deadline 20 Feb 2026 | 8 articles | Viewed by 16144 | Submission Open

Keywords: amenorrhea; puberty; PCOS; premature ovarian insufficiency; endometriosis; infertility; pregnancy; hormones; menopause

(This special issue belongs to the Section Obstetrics & Gynecology)

Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions

edited by Mauro Zaccarelli and

Alessandra Latini

submission deadline 20 Feb 2026 | 5 articles | Viewed by 15252 | Submission Open

Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex

(This special issue belongs to the Section Infectious Diseases)

Displaying special issue 601-650 on page 13 of 31.

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