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Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care
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Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 2583

Special Issue Editor

Dr. Konstantinos Stathogiannis

E-Mail Website
Guest Editor
Transcatheter Heart Valves Department, Hygeia Hospital, HEAL Academy, Athens, Greece
Interests: cardiology; interventional cardiology; aortic valve; tricuspid valve; cardiac surgery

Special Issue Information

Dear Colleagues,

Recent advancements in interventional cardiology have revolutionized minimally invasive approaches to diagnosing and treating cardiovascular diseases. Innovations such as transcatheter aortic valve replacement (TAVR), mitral valve repair systems (MTEERs), tricuspid valve repair (TTEER) and replacement (TTVR) platforms, and bioresorbable stents are reducing our reliance on open-heart surgeries, lowering risks, and improving patient recovery times. Enhanced imaging technologies, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), enable precise procedural guidance, while robot-assisted platforms enhance operator precision. These breakthroughs have expanded treatment options for patients and allowed us to address complex conditions such as coronary artery disease and structural heart disease. Ongoing research is focused on refining device durability, optimizing patient selection, and integrating artificial intelligence into personalized care. Together, these innovations underscore a transformative shift toward safer, more efficient, and patient-centric cardiac interventions.

Dr. Konstantinos Stathogiannis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • TAVI
  • TAVR
  • MTEER
  • TTEER
  • TTVR
  • ASD
  • PFO
  • IVUS
  • OCT

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Published Papers (2 papers)

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Review

26 pages, 2245 KB  
Review
The Two-Device Problem: A Comprehensive Framework for Managing Transvalvular CIED Leads in the Era of Transcatheter Tricuspid Intervention
by Mohammed Hussein Kamareddine, Edward M. Powers, Faisal Rahman, Ali R. Keramati and Konstantinos N. Aronis
J. Clin. Med. 2026, 15(3), 1303; https://doi.org/10.3390/jcm15031303 - 6 Feb 2026
Viewed by 894
Abstract
Tricuspid regurgitation (TR) in patients with transvalvular cardiac implantable electronic device (CIED) leads is increasingly encountered as transcatheter tricuspid valve interventions (TTVI) expand, yet integrated guidance for managing this “two-device problem” remains limited. We performed a focused synthesis of contemporary evidence, organizing findings [...] Read more.
Tricuspid regurgitation (TR) in patients with transvalvular cardiac implantable electronic device (CIED) leads is increasingly encountered as transcatheter tricuspid valve interventions (TTVI) expand, yet integrated guidance for managing this “two-device problem” remains limited. We performed a focused synthesis of contemporary evidence, organizing findings around mechanisms and diagnosis of TR in the setting of CIED leads, lead–device interactions across TTVI platforms, and clinical trade-offs of transvenous lead extraction (TLE) versus lead preservation or jailing. CIED-associated TR can arise from lead–leaflet impingement, leaflet injury, fibrotic adhesion, pacing-induced remodeling, or infection; true CIED-induced TR accounts for a minority of clinically significant TR, yet progression of TR after lead implantation occurs in 7–45% of patients, and moderate-to-severe TR in CIED populations is associated with 1.6- to 2.5-fold increased mortality risk. Lead conflict and lifetime consequences differ by TTVI modality: repair approaches are generally more lead-tolerant, whereas valve replacement creates obligate lead jailing with implications for lead performance, future extraction feasibility, and infection management. Management of TR with transvalvular CIED leads requires integrated Heart Team planning that anticipates downstream device needs. Standardized TR phenotyping, lead-aware TTVI selection, valve-sparing rhythm-device strategies, and structured post-procedural surveillance may improve outcomes; prospective studies are needed to define optimal extract-versus-jail pathways. Full article
(This article belongs to the Special Issue Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care)
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22 pages, 3984 KB  
Review
From Evidence to Practice: The Growing Role of Angiography-Derived Physiology
by Daniel K. Amponsah and William F. Fearon
J. Clin. Med. 2025, 14(22), 8219; https://doi.org/10.3390/jcm14228219 - 20 Nov 2025
Viewed by 1176
Abstract
Angiography-derived physiology (ADP) has emerged as a validated, wire-free method for the functional assessment of coronary artery disease (CAD). By avoiding pressure-wire instrumentation and hyperemic agents, ADP reduces procedure time, radiation exposure, and cost, while maintaining strong diagnostic performance with invasive physiology. These [...] Read more.
Angiography-derived physiology (ADP) has emerged as a validated, wire-free method for the functional assessment of coronary artery disease (CAD). By avoiding pressure-wire instrumentation and hyperemic agents, ADP reduces procedure time, radiation exposure, and cost, while maintaining strong diagnostic performance with invasive physiology. These platforms include FFRangio (CathWorks), QFR (Medis Medical Imaging), and vFFR (Pie Medical Imaging), which have undergone extensive validation and are FDA approved for use. Randomized trials, predominantly with QFR, thus far demonstrate improved outcomes of ADP-guided strategies compared with angiography alone, whereas non-inferiority to wire-based FFR guidance has not yet been established. As clinical trials continue, thoughtful integration into routine practice requires careful image acquisition, platform-specific training, and awareness of limitations. In particular, validation remains incomplete in complex subsets such as left main disease, bifurcations, and bypass grafts, though evidence is growing in the application in acute coronary syndromes, post-PCI prognostication, and surgical planning. As ongoing studies mature and ADP technology evolves, these tools are poised to reshape physiologic assessment, streamline catheterization laboratory workflow, and become integral to contemporary PCI planning and optimization. This review summarizes current evidence, clinical applications, limitations, integration into the catheterization lab, and future directions of ADP. Full article
(This article belongs to the Special Issue Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care)
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