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Periodontal Diseases and Systemic Health: Pathogenesis, Prevention and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 63

Special Issue Editor


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Guest Editor
Department of Stomatology, Tuscan Stomatologic Institute, Foundation for Dental Clinic, Research and Continuing Education, 55041 Camaiore, Italy
Interests: oral surgery; dental implants; manteinance of implant-prosthetic rehabilitation; bone biology; atrophic jaws; periodontal treatments; peri-implantitis; oral health; periomedicine

Special Issue Information

Dear Colleagues,

This Special Issue explores the critical intersection between periodontal health and systemic diseases. Growing evidence underscores the impact of periodontal inflammation on conditions such as diabetes, cardiovascular disease, and adverse pregnancy outcomes. This issue aims to provide a comprehensive overview of these interactions, offering insights for clinicians and researchers alike.

We welcome submissions on the following:

  • Mechanisms linking periodontal pathogens to systemic inflammation;
  • Clinical evidence on periodontal treatment and systemic disease outcomes;
  • Preventive approaches for at-risk populations;
  • Interdisciplinary management strategies in implant-prosthetic rehabilitation.

Dr. Saverio Cosola
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontitis
  • dental implants
  • systemic inflammation
  • diabetes and periodontal disease
  • cardiovascular implications
  • pregnancy and oral health
  • host immune responses
  • preventive dentistry
  • implant-prosthetic rehabilitation

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Published Papers (1 paper)

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25 pages, 1137 KiB  
Systematic Review
Neurosensory Disturbances Following Inferior Alveolar Nerve Relocation and Implant Placement: A Systematic Review and Meta-Analysis
by Raffaele Vinci, Saverio Cosola, Korath Varkey M, Sowndarya Gunasekaran, Jaibin George and Ugo Covani
J. Clin. Med. 2025, 14(16), 5741; https://doi.org/10.3390/jcm14165741 (registering DOI) - 14 Aug 2025
Abstract
Background: Rehabilitation of atrophic posterior mandibles using dental implants is often complicated by anatomical limitations, particularly the proximity of the inferior alveolar nerve (IAN). Techniques such as IAN lateralization and transposition enable implant placement but are associated with neurosensory disturbances (NSDs). This systematic [...] Read more.
Background: Rehabilitation of atrophic posterior mandibles using dental implants is often complicated by anatomical limitations, particularly the proximity of the inferior alveolar nerve (IAN). Techniques such as IAN lateralization and transposition enable implant placement but are associated with neurosensory disturbances (NSDs). This systematic review and meta-analysis aimed to assess the incidence, duration, and predictors of NSDs following IAN repositioning for implant placement and to evaluate the effectiveness of adjunctive methods like piezo-surgery and platelet-rich fibrin (PRF) in minimizing complications. Methods: Following PRISMA 2020 guidelines, a comprehensive search of electronic databases and gray literature identified 20 studies, including randomized controlled trials, prospective cohorts, and retrospective analyses published between 2009 and 2024. Outcomes analyzed included incidence of NSDs, recovery rates, implant stability quotient (ISQ), marginal bone loss, and implant success rates. Meta-analysis was performed using RevMan 5.3 software, with heterogeneity and publication bias assessed using standard Cochrane tools. Results: Transient NSDs occurred in 15–40% of cases, with higher rates observed in transposition techniques. Most patients experienced recovery within 6 months. Piezoelectric surgery significantly reduced the incidence and duration of NSDs compared to rotary instruments. Meta-analysis revealed no statistically significant differences between lateralization and transposition techniques in ISQ, marginal bone loss, success rate, or NSDs at 3 months (p > 0.05). PRF was associated with accelerated nerve recovery. IAN repositioning is effective for implant placement in atrophic mandibles with a risk of transient NSDs. Conclusions: Lateralization combined with piezo-surgery and PRF shows favorable outcomes in minimizing nerve injury and optimizing implant success. The PROSPERO registration code is as follows: CRD420251086835. Full article
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