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Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional...
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Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: closed (10 February 2026) | Viewed by 714

Special Issue Editor

Dr. Massimiliano Creta

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
Interests: bladder cancer; radical cystectomty; radical nephroureterectomy; transurethral resection of bladder tumor; upper urinary tract urothelian carcinoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The history of urinary stone disease goes back to the Ancient Egyptians and Mesopotamia. Hippocrates defined the symptoms of bladder stones and the first recorded details of “perineal lithotomy” were those of Cornelius Celsus. Currently, urolithiasis represents one of the most common urologic diagnoses globally, with significant burden and cost on healthcare systems worldwide. In recent years, several advances have strongly contributed to rapid evolution stone management: the miniaturization of instruments; the introduction of new laser technologies; the development of stone debris removal systems; the development of new biomaterials, new coatings, and new stent designs; and robotic surgery. Technological advances have helped to tailor management to the individual patient, attain better stone-free rates, decrease complication rates, and improve quality of life. Patient selection, long-term outcomes, and the management of patients with abnormal anatomies still represent open issues. In this Special Issue, we welcome authors to submit papers concerning the advancement of surgery in the field of urolithiasis, including extracorporeal shock wave therapy, ureteroscopy, percutaneous surgery, robotic surgery.

Prof. Dr. Massimiliano Creta
Guest Editor

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Keywords

  • extracorporeal shock wave lithotripsy
  • lasers
  • percutaneous lithotripsy
  • robotic surgery
  • ureteroscopy
  • urolithiasis

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Published Papers (1 paper)

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Research

10 pages, 629 KB  
Article
Effect of Adjuvant Silodosin on Stone Clearance After Extracorporeal Shock Wave Lithotripsy for Renal Stones: A Randomised Controlled Trial
by Phanpon Leelahawong and Chinnakhet Ketsuwan
J. Clin. Med. 2026, 15(7), 2471; https://doi.org/10.3390/jcm15072471 - 24 Mar 2026
Viewed by 298
Abstract
Background/Objectives: To evaluate whether adjunctive silodosin improves the stone-free rate (SFR) and clinical outcomes of extracorporeal shock wave lithotripsy (ESWL) for renal calculi. Methods: In this prospective randomised controlled trial, 100 adults with solitary radiopaque non-lower pole renal stones measuring 5–20 [...] Read more.
Background/Objectives: To evaluate whether adjunctive silodosin improves the stone-free rate (SFR) and clinical outcomes of extracorporeal shock wave lithotripsy (ESWL) for renal calculi. Methods: In this prospective randomised controlled trial, 100 adults with solitary radiopaque non-lower pole renal stones measuring 5–20 mm underwent single-session ESWL and were randomised (1:1) to receive either silodosin 8 mg once daily plus standard care or standard care alone for up to 12 weeks. Participants were followed up for three months. The primary outcome was SFR at three months on follow-up imaging. The secondary outcomes included time to stone clearance, renal colic episodes, analgesic requirement and adverse events. Results: At three months, the SFR was higher in the silodosin group than in the control group (68.0% vs. 50.0%; RR 1.36, 95% CI 0.97–1.90), but this difference did not reach statistical significance (p = 0.067). In a prespecified exploratory subgroup analysis, patients with stones measuring 10–20 mm showed a higher SFR with silodosin than controls (61.8% vs. 34.4%; p = 0.026), whereas no benefit was observed for stones measuring 5–9 mm (p = 0.803). Time-to-clearance analysis using Kaplan–Meier methods suggested earlier confirmed stone clearance in the silodosin group (hazard ratio 1.58, 95% CI 1.02–2.45; log-rank p = 0.036). Silodosin was also associated with fewer renal colic episodes and lower analgesic requirements. No serious drug-related adverse events were observed. Conclusions: This randomised controlled trial did not meet its primary endpoint because adjunctive silodosin did not significantly improve the overall SFR after ESWL. However, a possible benefit was observed in patients with renal stones measuring 10–20 mm, together with improved pain-related outcomes. These findings suggest that silodosin may have a role in selected patients, but the subgroup effects should be considered hypothesis-generating rather than definitive. Full article
(This article belongs to the Special Issue Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence)
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