Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances

Dear Colleagues,

The pancreas is a complex organ, integral to both exocrine and endocrine systems, through its binary functions of digestive enzyme secretion and hormone synthesis. Despite its physiological importance, it remains vulnerable to a range of severe diseases, most notably acute and chronic pancreatitis, and pancreatic ductal adenocarcinoma (PDAC), the latter being one of the deadliest cancers worldwide. The insidious nature of pancreatic diseases, coupled with diagnostic complexities and the often-inflamed tumor microenvironment of pancreatic cancer, underscores an urgent need for innovative research. The overlapping pathophysiological pathways among these diseases, their complex clinical presentations, and the limited efficacy of current diagnostic and therapeutic strategies render pancreatic diseases a persistent global health concern.                          

This Special Issue invites high-quality original research and comprehensive reviews that delve into the molecular and clinical connections between pancreatitis, pancreatic cancer, and other pancreatic disorders. We welcome contributions that address novel insights into disease pathogenesis, innovative diagnostic tools for early detection, and advances in treatment modalities—from precision oncology approaches and targeted therapies to immunotherapies and surgical and neoadjuvant strategies aimed at overcoming resistance. Generating interdisciplinary knowledge, this collection aspires to spark progress in translational research and ultimately improve outcomes for patients affected by pancreatic disease.

Dr. Cristian George Ţieranu
Prof. Dr. Adrian Saftoiu
Guest Editors

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