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Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: 25 August 2026 | Viewed by 1482

Special Issue Editors

Dr. Eleonora M.C. Trecca

E-Mail Website
Guest Editor
Department of Otolaryngology, University Hospital of Foggia, 71100 Foggia, Italy
Interests: otorhinolaryngologic diseases; regenerative medicine; rhinology; otology; otolaryngology
Special Issues, Collections and Topics in MDPI journals
Dr. Andrea Albera

E-Mail Website
Guest Editor
Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy
Interests: otology; otoneurology; middle ear surgery; cochlear implants; bone-conduction hearing aids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue entitled “Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition”. In our previous Special Issue entitled “Clinical Diagnosis and Surgical Strategies Update on Ear Disorders”, we collected original articles covering a wide range of topics and systematic review papers. This is a continuation of the previous series.

Recent advances in neurosciences, technology and imaging techniques have greatly improved our understanding and treatment of ear disorders. Electrophysiology and neuroscientific approaches are crucial for improving our understanding of the mechanisms underlying pathologies, such as congenital or acquired sensorineural hearing loss, autoimmune or metabolic hearing loss, otogenic facial palsy, Menière's disease, and tinnitus, among others.

We are now in an era of "minimally invasive surgery": chronic otitis media, cholesteatoma, otosclerosis, profound deafness and acoustic neuroma can now be treated both microscopically and endoscopically. Furthermore, other interventions are starting to consider lasers, robotic surgery, and image-guided navigation as other viable options.

The aim of this Special Issue is to present original studies and state-of-the-art systematic reviews related to clinical updates on middle and inner ear diseases, as well as cutting-edge original research on innovative surgical techniques, both in children and adults.

Dr. Eleonora M.C. Trecca
Dr. Andrea Albera
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • middle ear
  • inner ear
  • endoscopic ear surgery
  • cholesteatoma
  • Menière’s disease
  • hearing loss
  • robotic surgery
  • oto-sclerosis

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Related Special Issue

Published Papers (3 papers)

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Research

14 pages, 1062 KB  
Article
The Potential Impact of Serum Sodium and Potassium Levels on Sensorineural Hearing Loss and Tinnitus
by Stefani Maihoub, Panayiota Mavrogeni, Aphrodite Mavrogenis and András Molnár
J. Clin. Med. 2026, 15(6), 2225; https://doi.org/10.3390/jcm15062225 - 15 Mar 2026
Viewed by 129
Abstract
Objectives: This study aimed to analyse the impact of serum sodium and potassium levels on sensorineural hearing loss and tinnitus. Material and Methods: A total of 616 individuals participated—248 with sensorineural hearing loss and tinnitus, 136 with tinnitus only, and 232 controls. All [...] Read more.
Objectives: This study aimed to analyse the impact of serum sodium and potassium levels on sensorineural hearing loss and tinnitus. Material and Methods: A total of 616 individuals participated—248 with sensorineural hearing loss and tinnitus, 136 with tinnitus only, and 232 controls. All patients received thorough examinations by specialists in otorhinolaryngology and audiology. Additionally, all participants underwent laboratory testing. Results: Serum sodium levels were slightly elevated in the tinnitus group with sensorineural hearing loss compared to both the tinnitus group and the control group, although these differences were not statistically significant (p = 0.27 and p = 0.89). Additionally, this trend was not observed when comparing the tinnitus group to the control group (p = 0.32). The serum potassium levels did not show a significant difference among the three groups (p = 0.155). In the group experiencing sensorineural hearing loss and tinnitus, a significant positive correlation was found between serum sodium levels and the onset of sensorineural hearing loss (p = 0.000, rho = 0.223). Additionally, there was a significant correlation between age and the onset of symptoms (p = 0.000, rho = 0.235). No significant correlations were found regarding serum potassium levels. Patients with hearing levels exceeding 40 dB exhibited slightly higher serum sodium levels (p = 0.56). Both the groups with tinnitus and sensorineural hearing loss, as well as the tinnitus-only group, showed a trend indicating that higher serum sodium levels were associated with greater tinnitus intensities (p = 0.43 and p = 0.62, respectively). A logistic regression analysis indicated that the development of sensorineural hearing loss and tinnitus was significantly associated with changes in serum sodium levels (p = 0.030; OR: 0.186, 95% CI = 0.027–5.550). Additionally, serum sodium levels were found to be significant predictors of more severe hearing loss, defined as hearing levels exceeding 40 dB (p = 0.019; OR: 1.950, 95% CI = 0.504–7.540). Conclusions: The findings of this investigation suggest that changes in serum sodium levels may influence the development and severity of tinnitus and sensorineural hearing loss. Further studies involving more cases are needed to solidify these results. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition)
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18 pages, 1770 KB  
Article
Quality of Life Outcomes After Endoscopic Cholesteatoma Surgery: A Prospective Cohort Study
by Luana-Maria Gherasie, Viorel Zainea, Tamer Ebaied, Razvan Hainarosie, Corina Daniela Negrila, Andreea Rusescu, Irina-Gabriela Ionita and Catalina Voiosu
J. Clin. Med. 2026, 15(4), 1556; https://doi.org/10.3390/jcm15041556 - 16 Feb 2026
Viewed by 482
Abstract
Background: Cholesteatoma is a destructive middle ear lesion that compromises hearing and quality of life, for which endoscopic ear surgery (EES) has emerged as a minimally invasive alternative to microscopic approaches. While recurrence and audiological outcomes are frequently reported, patient-centered evaluations using validated [...] Read more.
Background: Cholesteatoma is a destructive middle ear lesion that compromises hearing and quality of life, for which endoscopic ear surgery (EES) has emerged as a minimally invasive alternative to microscopic approaches. While recurrence and audiological outcomes are frequently reported, patient-centered evaluations using validated patient-reported outcome measures (PROMs) remain limited. Objective: This study aimed to assess postoperative quality of life in patients undergoing exclusive endoscopic cholesteatoma surgery, using validated patient-reported outcome measures. Methods: We conducted a prospective observational cohort study in a tertiary referral center, enrolling 41 patients who underwent exclusive endoscopic cholesteatoma surgery over 20 months. Pre- and postoperative QoL was assessed using the Chronic Otitis Media Questionnaire-12 (COMQ-12) and the Glasgow Benefit Inventory (GBI). Results: COMQ-12 scores improved significantly from baseline (54.0 ± 4.2) to 12 months (10.2 ± 3.3; mean difference −43.8, 95% CI: −46.1 to −41.5; p < 0.001). GBI scores were consistently high, increasing from 82.6 ± 4.8 at 6 months to 84.1 ± 4.9 at 12 months (p < 0.001). Audiometric evaluation demonstrated a significant postoperative improvement, with the mean air–bone gap (ABG) decreasing from 52.1 ± 5.3 dB preoperatively to 26.4 ± 4.7 dB postoperatively (p < 0.001), indicating substantial closure of the conductive gap. Conclusions: Exclusive endoscopic cholesteatoma surgery yields robust QoL improvement, favourable hearing outcome, and recurrence rates similar to classic techniques at short-term evaluation. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition)
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18 pages, 1649 KB  
Article
Managing Complex Chronic Otitis Media: Insights from Subtotal Petrosectomy with Blind Sac Closure
by Angelo Immordino, Simone Oliva, Palmira Immordino, Federico Sireci, Francesco Lorusso, Riccardo Manzella, Salvatore Gallina, Antonino Maniaci, Giannicola Iannella, Quentin Mat and Francesco Dispenza
J. Clin. Med. 2025, 14(24), 8633; https://doi.org/10.3390/jcm14248633 - 5 Dec 2025
Viewed by 790
Abstract
Objectives: Chronic otitis media poses a surgical challenge, and subtotal petrosectomy represents a last-resort intervention. This study aims to evaluate the efficacy and safety of subtotal petrosectomy with blind sac closure of the external auditory canal in managing chronic and recurrent otitis [...] Read more.
Objectives: Chronic otitis media poses a surgical challenge, and subtotal petrosectomy represents a last-resort intervention. This study aims to evaluate the efficacy and safety of subtotal petrosectomy with blind sac closure of the external auditory canal in managing chronic and recurrent otitis media by sharing our experiences and discussing the findings from a comprehensive literature review. Methods: A retrospective analysis including nine patients undergoing subtotal petrosectomy with blind sac closure of the external auditory canal was conducted. Additionally, two independent otolaryngologists conducted a review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The criteria for considering studies for the review were based on the population, intervention, comparison, outcome, timing, and setting (PICOTS) framework. Results: Our retrospective analysis comprised eight chronic cholesteatomatous otitis media cases and one atelectatic case. No postoperative complications occurred. The literature review discussed SP applications, surgical techniques, and outcomes from 17 selected studies. Conclusions: Subtotal petrosectomy with blind sac closure of the external auditory canal effectively manages chronic otitis, exhibiting minimal complications and improved postoperative outcomes. Despite study limitations, including a small sample size, this research provides valuable insights into subtotal petrosectomy’s application and success. The literature review enhances understanding by summarizing findings from diverse studies, offering a comprehensive view of the procedure’s evolution and applications. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition)
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