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Advances in Traumatic Brain Injury: Causes and Recovery
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Advances in Traumatic Brain Injury: Causes and Recovery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Brain Injury".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 579

Special Issue Editor

Dr. Antonio Bonora

E-Mail Website
Guest Editor
Emergency and Intensive Care Department, University of Verona, Verona, Italy
Interests: mild traumatic brain injury; atrial fibrillation; sepsis; biomarkers

Special Issue Information

Dear Colleagues,

Traumatic brain injury (TBI) is a very frequent cause of admission in emergency departments, with a higher incidence among all common neurological events, and it represents a leading cause of injury-related death and disability worldwide.

TBI has a wide range of clinical presentations, ranging from severe trauma with life-threatening brain injuries to mild trauma not requiring any measures. Nonetheless, despite continuous technical advancements in the past two decades, TBI still remains a diagnostic and therapeutic challenge.

With the aim of improving the treatment outcomes and quality of life of TBI patients, we invite contributions about the most relevant clinical aspects that need to be investigated. The contributions could be focused on the following topics, including but not limited to:

  • Advances in neuroimaging and diagnostic tools;
  • Progress in neurosurgical and intensive care techniques;
  • Pharmacological and non-pharmacological interventions;
  • The development of biomarkers for assessing the severity and prognosis of TBI;
  • Rehabilitation and cognitive outcomes.

This Special Issue aims to collect original research articles and reviews to provide valuable insights and guidance for clinicians, researchers, and professionals in related fields. We look forward to your contributions that will enrich this critical area of study and underscore the importance of ongoing research in traumatic brain injury.

Dr. Antonio Bonora
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mild traumatic brain injury
  • TBI
  • brain injuries
  • neuroimaging
  • rehabilitation

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

9 pages, 207 KB  
Article
Impact of Different DOACs on Complications of TBI After Low-Energy Trauma
by Anna Antoni, Philipp Puhl, Lukas Wedrich, Rebecca Wagner, Matthias Millesi, Valerie Weihs, Elisabeth Schwendenwein, Silke Aldrian and Stefan Hajdu
J. Clin. Med. 2025, 14(24), 8787; https://doi.org/10.3390/jcm14248787 - 11 Dec 2025
Viewed by 281
Abstract
Background/Objectives: While direct oral anticoagulants (DOACs) are widely used, robust evidence for low-energy trauma is scarce. Studies have shown similar or better outcomes of traumatic brain injury (TBI) under DOAC therapy compared to vitamin K antagonists, but there is limited data on the [...] Read more.
Background/Objectives: While direct oral anticoagulants (DOACs) are widely used, robust evidence for low-energy trauma is scarce. Studies have shown similar or better outcomes of traumatic brain injury (TBI) under DOAC therapy compared to vitamin K antagonists, but there is limited data on the differences among DOAC types. Methods: We performed a retrospective study of TBI patients with pre-injury DOACs who presented to our level 1 trauma unit and received cranial computed tomography. Only low-energy trauma mechanisms were included. Results: We included 643 patients with an average age of 82 years. As per the Glasgow Coma Scale, 637 patients (99.1%) had a mild TBI and 34 patients (5.3%) had intracranial hematomas. No delayed intracranial bleeding occurred during in-hospital observation. Rivaroxaban was the most frequent DOAC (278, 43.2%), followed by apixaban (221, 34.4%), dabigatran (84, 13.1%), and edoxaban (60, 9.3%). Neurosurgical interventions were performed in three cases (0.5%). The head injury-related in-hospital mortality was 0.9% (six patients). Fisher’s Exact Test and regression analysis did not demonstrate statistically significant differences among the DOAC types regarding occurrence of intracranial bleeding, surgical interventions, or mortality. Conclusions: We found no statistically significant differences between DOACs regarding complications of TBI after low-energy trauma. This study shows an overall low risk of complications after low-energy trauma in a predominantly geriatric population with TBI and DOAC therapy. Full article
(This article belongs to the Special Issue Advances in Traumatic Brain Injury: Causes and Recovery)
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