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Eosinophilic Esophagitis: Clinical Advances in Diagnosis, Treatment, and Monitoring

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 21 August 2025 | Viewed by 1194

Special Issue Editors


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Guest Editor
Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
Interests: eosinophilic esophagitis; eosinophilic gastrointestinal diseases; esophageal motility; esophageal physiology; gastroesophageal reflux disease (GERD); chronic esophageal diseases
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
Interests: eosinophilic esophagitis; gastroesophageal reflux disease (GERD); esophageal dysmotility; irritable bowel syndrome (IBS); inflammatory bowel disease (IBD)

E-Mail
Guest Editor
Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
Interests: eosinophilic esophagitis; gastroesophageal reflux disease (GERD); esophageal dysmotility; irritable bowel syndrome (IBS); inflammatory bowel disease (IBD)

Special Issue Information

Dear Colleagues,

We are delighted to announce a call for papers for a Special Issue of Journal of Clinical Medicine focused on the latest advances in the diagnosis, treatment, and monitoring of eosinophilic esophagitis (EoE). As a complex chronic, immune-mediated esophageal disease, EoE presents unique challenges in clinical practice and research, necessitating innovative approaches to improve patient outcomes.

This Special Issue seeks to gather insightful reviews that explore cutting-edge developments in the field of EoE. Topics of interest include, but are not limited to, novel diagnostic techniques, emerging therapeutic strategies, and advanced monitoring methods for EoE. We also welcome contributions addressing the underlying pathophysiology of the disease, patient-reported outcomes, and multidisciplinary management approaches.

By bringing together the latest findings from leading experts and researchers, this Special Issue aims to enhance our understanding of EoE and foster the development of more effective, personalized treatment plans. We encourage submissions that provide significant advancements and provoke thoughtful discussion within the medical and scientific communities.

Manuscripts should be submitted by February 2025 through the online submission system of JCM.

We look forward to receiving your submissions.

Dr. Pierfrancesco Visaggi
Prof. Edoardo Vincenzo Savarino
Dr. Nicola De Bortoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eosinophilic esophagitis (EoE)
  • diagnosis 
  • treatment 
  • monitoring
  • disease assessment
  • precision medicine

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Published Papers (1 paper)

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Review

18 pages, 823 KiB  
Review
Endoscopic Management of Eosinophilic Esophagitis: A Narrative Review on Diagnosis and Treatment
by Andrea Pasta, Francesco Calabrese, Manuele Furnari, Edoardo Vincenzo Savarino, Pierfrancesco Visaggi, Giorgia Bodini, Elena Formisano, Patrizia Zentilin, Edoardo Giovanni Giannini and Elisa Marabotto
J. Clin. Med. 2025, 14(11), 3756; https://doi.org/10.3390/jcm14113756 - 27 May 2025
Viewed by 820
Abstract
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease characterized by esophageal eosinophilic infiltration, leading to symptoms such as dysphagia and food impaction. Endoscopy is central to both diagnosis and management, allowing for the direct visualization of characteristic features, biopsy collection, and therapeutic interventions. [...] Read more.
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease characterized by esophageal eosinophilic infiltration, leading to symptoms such as dysphagia and food impaction. Endoscopy is central to both diagnosis and management, allowing for the direct visualization of characteristic features, biopsy collection, and therapeutic interventions. Despite its diagnostic value, up to one-third of patients may present with a normal-appearing esophagus, highlighting the importance of standardized scoring systems and a systematic biopsy approach. This review explores the evolving role of endoscopy in EoE, from traditional diagnostic methods to emerging technologies such as EndoFlip™ for assessing esophageal distensibility, transnasal endoscopy for non-sedated monitoring, and novel dilation techniques for fibrostenotic disease. Additionally, non-invasive biomarkers and minimally invasive tools are reshaping disease monitoring. By integrating endoscopic, histologic, and molecular approaches, future advancements may enhance diagnostic accuracy and optimize personalized treatment strategies for EoE. Full article
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