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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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POTS, ME/CFS and Long COVID: Recent Advances and Future Direction
edited by Svetlana Blitshteyn
submission deadline 20 Jan 2026 | 2 articles | Viewed by 12949 | Submission Open
Keywords: POTS; ME/CFS; long COVID; dysautonomia; orthostatic intolerance; autoimmunity
(This special issue belongs to the Section Immunology & Rheumatology)
Oral Health in Children: Clinical Management submission deadline 20 Jan 2026 | 7 articles | Viewed by 11901 | Submission Open
Keywords: pediatric oral health; early childhood caries; preventive strategies; comprehensive clinical approach; early detection; oral care; minimal intervention dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Traumatic Brain Injury: Current Treatment and Future Options
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 10746 | Submission Open
Keywords: traumatic brain injury; trauma; biomarkers; post-traumatic outcome; epidemiology
(This special issue belongs to the Section Clinical Neurology)
Plastic Surgery: Challenges and Future Directions
edited by Philip Brazio and Edward C. Ray
submission deadline 20 Jan 2026 | 5 articles | Viewed by 10364 | Submission Open
Keywords: plastic surgery; reconstructive surgery; esthetic surgery; innovation; challenges; technology
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Foot and Ankle Surgery: State of the Art and Future Perspectives
edited by Sung Jae Kim and Jaehwang Song
submission deadline 20 Jan 2026 | 5 articles | Viewed by 10032 | Submission Open
Keywords: foot and ankle surgery; hallux disorders; lesser toe problem; diabetic foot salvage; calcaneal fracture; pilon fracture; ligament disorder
(This special issue belongs to the Section Orthopedics)
Attention-Deficit/Hyperactivity Disorder (ADHD): Advances in Diagnosis and Treatment
edited by Yanli Zhang-James
submission deadline 20 Jan 2026 | 3 articles | Viewed by 9908 | Submission Open
Keywords: attention-deficit/hyperactivity disorder; neurodevelopmental disorder; hyperactivity; children; adolescents; adult
(This special issue belongs to the Section Clinical Neurology)
Innovative Clinical Approaches in Oral Health Prevention and Management
edited by , and Flavia Vitiello
submission deadline 20 Jan 2026 | 7 articles | Viewed by 8463 | Submission Open
Keywords: oral health; oral prevention; teeth remineralization; oral pathology; oral health management; preventive dentistry; translational dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition
edited by and Panagiota Christia
submission deadline 20 Jan 2026 | 4 articles | Viewed by 7996 | Submission Open
Keywords: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease
(This special issue belongs to the Section Cardiology)
Hip Fracture and Surgery: Clinical Updates and Challenges
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7882 | Submission Open
Keywords: antiosteoporosis medication; fracture liaison service; osteosynthesis; total hip arthroplasty; hemiarthroplasty
(This special issue belongs to the Section Orthopedics)
Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques
edited by , Aniello Iovino and Vito Stifano
submission deadline 20 Jan 2026 | 4 articles | Viewed by 6997 | Submission Open
Keywords: MRI; MSK imaging; soft-tissue tumors; DTI; neuropathies; inflammatory neuropathies; nerve entrapment; motor neuron disease; neurophysiology; MSK ultrasound; peripheral nerve tumor; nerve entrapment; nerve reconstruction
(This special issue belongs to the Section Clinical Neurology)
Advancing Psycho-Oncology: Multidimensional Approaches and Challenges to Cancer Care submission deadline 20 Jan 2026 | 3 articles | Viewed by 6758 | Submission Open
Keywords: psycho-oncology; cancer care; adaptation process; illness experience; risk and protective factors; mental health care; oncofertility; palliative care; critical experience; prevention; qualitative and quantitative methods; quality of life; health behaviors
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis, Risk Stratification, and Personalized Management in Acute Coronary Syndromes
edited by , Barbara P. Fyntanidou and
submission deadline 20 Jan 2026 | 5 articles | Viewed by 6040 | Submission Open
Keywords: acute coronary syndrome (ACS); cardiovascular disease (CVD); ischemic heart disease; emergency medicine; risk stratification; personalized treatment; antiplatelets; primary and secondary prevention
(This special issue belongs to the Section Cardiology)
New Advances in Cardiovascular Diseases: The Cutting Edge
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 5946 | Submission Open
Keywords: cardiovascular disease (CVD); preventive cardiology; cardiac pharmacology; coronary artery disease (CAD); heart failure (HF); atrial fibrillation (AF); supraventricular and ventricular arrhythmias
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Challenges of Pelvic Floor Disorders Management
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 5878 | Submission Open
Keywords: pelvic floor disorders; pelvic organ prolapse; urinary incontinence; surgery; diagnostics; pelvic pain; vulvodynia; urinary tract symptoms; mesh-related complications
(This special issue belongs to the Section Obstetrics & Gynecology)
Artificial Intelligence (AI) and Deep Learning (DL) in Medical Imaging submission deadline 20 Jan 2026 | 2 articles | Viewed by 5451 | Submission Open
Keywords: artificial intelligence; deep learning; imaging; diagnosis; precision medicine; oncologic
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Eating Disorders: Current Epidemiology and Advances in Diagnosis and Treatment—Second Edition submission deadline 20 Jan 2026 | 4 articles | Viewed by 5367 | Submission Open
Keywords: eating disorder; bulimia nervosa; anorexia nervosa; binge eating disorder; sociocultural context; epidemiology; di-agnosis; treatment; prevention
(This special issue belongs to the Section Mental Health)
Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome submission deadline 20 Jan 2026 | 3 articles | Viewed by 5209 | Submission Open
Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Microsurgery: Current and Future Challenges submission deadline 20 Jan 2026 | 5 articles | Viewed by 5163 | Submission Open
Keywords: microsurgery; reconstruction; reconstructive surgery; breast reconstruction; extremity reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Insights into Pediatric Critical Care
edited by Katherine Biagas and Daniel E Sloniewsky
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4783 | Submission Open
Keywords: PICU; anemia; blood transfusion; critically ill children; traumatic hemorrhage
(This special issue belongs to the Section Intensive Care)
Clinical Advances in Autoimmune Disorders submission deadline 20 Jan 2026 | 4 articles | Viewed by 4512 | Submission Open
Keywords: systemic sclerosis; Raynaud’ s phenomenon; digital ulcers; scleroderma renal crisis; pulmonary arterial hypertension; interstitial lung disease; fibrosis
(This special issue belongs to the Section Immunology & Rheumatology)
Allergen-Specific Immunotherapy (AIT) for Allergic Diseases of the Respiratory Tract and Food Allergies
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4488 | Submission Open
Keywords: allergy; allergic rhinitis; allergic conjunctivitis; allergic asthma; food allergy; peptide immunotherapy; allergoids; SLIT; SCIT; OIT
(This special issue belongs to the Section Immunology & Rheumatology)
Sustaining Success Through Innovation in Kidney Transplantation
edited by Junji Uchida
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4354 | Submission Open
Keywords: kidney transplantation; long-term graft survival; immunosuppression; organ shortage; post-transplant complication
(This special issue belongs to the Section Nephrology & Urology)
Clinical Management of Cardiogenic Shock and Cardiac Arrest: 2nd Edition
edited by Jaime A. Hernández-Montfort
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4175 | Submission Open
Keywords: cardiogenic shock; cardiac arrest; temporary mechanical circulatory support; ECMO; transitions; heart recovery; heart replacement
(This special issue belongs to the Section Cardiology)
Long COVID and Cardiovascular Health: Clinical Perspectives on Risk and Management
edited by Mariana Tudoran and
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4154 | Submission Open
Keywords: long COVID; cardiovascular disease; long COVID therapy; management of long COVID; mechanisms of long COVID
(This special issue belongs to the Section Cardiovascular Medicine)
Sarcopenia Across the Lifespan: Risk Factors, Mechanisms, and Management in Aging and Disease submission deadline 20 Jan 2026 | 3 articles | Viewed by 4109 | Submission Open
Keywords: sarcopenia; aging; chronic disease; risk factors; muscle physiology; prevention; nutrition; exercise; treatment strategies
(This special issue belongs to the Section Orthopedics)
Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition
edited by Gerond V. Lake-Bakaar
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3906 | Submission Open
Keywords: NAFLD; NASH; cirrhosis; hepatocellular carcinoma; hepatitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Sports Injuries: Recent Advances in Prevention and Rehabilitation, 2nd Edition submission deadline 20 Jan 2026 | 2 articles | Viewed by 3867 | Submission Open
Keywords: sports injuries; treatment; musculoskeletal disorders; rehabilitation; physical rehabilitation; exercise science; sports science; injury prevention
(This special issue belongs to the Section Sports Medicine)
Emerging Treatment Options in Inflammatory Bowel Disease
edited by and Roberta Maselli
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3749 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; small molecule therapies; personalized medicine; therapeutic drug monitoring; immunology; gut microbiome; clinical practice; endoscopic mucosal resection (EMR); endoscopic submucosal dissection (ESD); endoscopic balloon dilation and endoscopic stent placement; chromoendoscopy; confocal laser endomicroscopy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Application of Radiotherapy in Modern Oncology submission deadline 20 Jan 2026 | 2 articles | Viewed by 3628 | Submission Open
Keywords: brain metastasis; bone metastasis; brain tumors; head and neck cancers; thoracic oncology; breast cancer; prostate cancer; sarcoma
(This special issue belongs to the Section Oncology)
Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3606 | Submission Open
Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke
(This special issue belongs to the Section Clinical Neurology)
Advances and Trends in Pediatric Surgery submission deadline 20 Jan 2026 | 4 articles | Viewed by 3559 | Submission Open
Keywords: pediatric surgery; minimally invasive surgery; robotics; trends; advances
(This special issue belongs to the Section Clinical Pediatrics)
Current and Emerging Therapies for Rheumatoid Arthritis
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3384 | Submission Open
Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)
(This special issue belongs to the Section Immunology & Rheumatology)
Insights and Innovations in Sports Cardiology submission deadline 20 Jan 2026 | 3 articles | Viewed by 3120 | Submission Open
Keywords: sports cardiology; athlete heart; cardiovascular screening; arrhythmias; sudden cardiac death; cardiac rehabilitation; exercise prescription; mobile health; preventive cardiology; personalized medicine; pediatric fitness
(This special issue belongs to the Section Sports Medicine)
Advances in the Treatment of Glaucoma and Ocular Hypertension
edited by Ahnul Ha
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3105 | Submission Open
Keywords: glaucoma; ocular hypertension; intraocular pressure (IOP); minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI); neuroprotection; meta-analysis
(This special issue belongs to the Section Ophthalmology)
Advanced Diagnostic and Therapeutic Strategies for Sarcoidosis submission deadline 20 Jan 2026 | 2 articles | Viewed by 2982 | Submission Open
Keywords: sarcoidosis; cardiac sarcoidosis; pulmonary fibrosis; magnetic resonance imaging; FDG-PET/CT; echocardiography; neurosarcoidosis; differential diagnosis; hypercalcaemia; IGRA; sarcoidosis-associated pulmonary hypertension; fatigue; corticosteroids; metotrexat; infliximab; antifibrotic treatment; lung transplantation; artificial intelligence; broncho-alveolar lavage; cytokines
(This special issue belongs to the Section Respiratory Medicine)
Advances in Tuberculosis: Comprehensive Insights and Management Strategies
edited by Aliaksandr Skrahin
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2651 | Submission Open
Keywords: pulmonary and extra-pulmonary tuberculosis (TB); TB epidemiology; TB screening; TB prevention; TB diagnostics; TB treatment; TB co-infections (e.g.; HIV; Hepatitis B and C); TB co-morbidities (e.g.; diabetes); host and Mycobacteria genetic; molecular mechanisms and genotype/phenotype correlations
(This special issue belongs to the Section Infectious Diseases)
Glaucoma Surgery: Current Challenges and Future Perspectives submission deadline 20 Jan 2026 | 3 articles | Viewed by 2312 | Submission Open
Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics
(This special issue belongs to the Section Ophthalmology)
Acute Myocardial Infarction: Diagnosis, Treatment, and Rehabilitation
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2107 | Submission Open
Keywords: acute myocardial infarction; coronary angioplasty; acute heart failure; cardiogenic shock; rehabilitation programs
(This special issue belongs to the Section Cardiovascular Medicine)
Endometriosis: Diagnosis and Treatment submission deadline 20 Jan 2026 | 2 articles | Viewed by 2087 | Submission Open
Keywords: endometriosis; diagnosis; video laparoscopy with and without robotic assistance; chronic pelvic pain; fertility preservation; minimally invasive surgery; biomarkers; artificial intelligence in endometriosis; adenomyosis; and adenomyoma care; multidisciplinary care; personalized medicine
(This special issue belongs to the Section Obstetrics & Gynecology)
Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases
edited by Mario J. Garcia and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1238 | Submission Open
Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S
(This special issue belongs to the Section Cardiology)
Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes
edited by Ivan Krečak, Marko Skelin and Zinaida Perić
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1187 | Submission Open
Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis
(This special issue belongs to the Section Hematology)
Cardiac Arrest Research: Neuroprognostication and Improving Outcomes
edited by and Jin-hong Min
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1105 | Submission Open
Keywords: cardiac arrest; prognosis; hypothermia; induced; resuscitation; magnetic resonance imaging; electroencephalography; blood pressure; hypoxia-ischemia; brain; extracorporeal membrane oxygenation
(This special issue belongs to the Section Cardiovascular Medicine)
Idiopathic Pulmonary Fibrosis (IPF): Current Perspectives and Future Directions
edited by Vito D’Agnano
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1058 | Submission Open
Keywords: pulmonary fibrosis; IPF; ILD; antifibrotics; EMT; respiratory physiology; metabolism
(This special issue belongs to the Section Respiratory Medicine)
Cardiac and Pulmonary Involvements in High-Risk Neonatal Cohorts: Short- and Long-Term Issues
edited by Arvind Sehgal
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1057 | Submission Open
Keywords: fetal growth restriction; lung disease; cardiac maladaptation; placenta; public health; neurodevelopment; long term; adulthood; Barker’ s hypothesis; newborn; vascular
(This special issue belongs to the Section Clinical Pediatrics)
Artificial Intelligence (AI) in Dental Clinical Practice
edited by and Keiichiro Watanabe
submission deadline 20 Jan 2026 | 1 articles | Viewed by 956 | Submission Open
Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Perspectives in Chronic Kidney Disease, Transplantation and Immune System
edited by and Dimitrios A. Tsakiris
submission deadline 20 Jan 2026 | 1 articles | Viewed by 932 | Submission Open
Keywords: kidney transplantation; HLA; matching at the epitope level; DSAs; complement; kidney disease epigenetics; diabetic nephropathy; hemostasis; graft rejection; B and T cell immunophenotyping; end stage renal disease
(This special issue belongs to the Section Nephrology & Urology)
Current Practice and Future Perspectives on Laryngeal Surgery submission deadline 20 Jan 2026 | 1 articles | Viewed by 917 | Submission Open
Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery
(This special issue belongs to the Section Otolaryngology)
Aortic Valve Disease: Current Evolution and Future Opportunities
edited by Gianluigi Perri
submission deadline 20 Jan 2026 | 1 articles | Viewed by 861 | Submission Open
Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease
(This special issue belongs to the Section Cardiology)
Rehabilitation and Treatment of Post-COVID-19 Condition submission deadline 20 Jan 2026 | 1 articles | Viewed by 815 | Submission Open
Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work
(This special issue belongs to the Section Clinical Rehabilitation)
Multiple Myeloma: Therapeutic and Management Strategies
edited by Terri Parker
submission deadline 20 Jan 2026 | 1 articles | Viewed by 795 | Submission Open
Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management
(This special issue belongs to the Section Hematology)
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