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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 20 Sep 2026 | 1 articles | Viewed by 3476 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition

edited by

Yutang Wang

and

Dianna Magliano

submission deadline 20 Sep 2026 | 3 articles | Viewed by 3376 | Submission Open

Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3332 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics; metabolomics; proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Damage to Plants and Microorganisms Caused by Heavy Metal Toxicity

edited by

Xiaomeng Chen

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3313 | Submission Open

Keywords: metal; oxidative stress; stress response; molecular function; gene regulation; metabolic regulation; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Phenolics and Polyphenols 2025

edited by

Davide Barreca

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3238 | Submission Open

Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments

edited by Angelo Delmonte and Alberto Verlicchi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 3167 | Submission Open

Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Plant Metabolism and Natural Product Biosynthesis

edited by

Andrej Frolov

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3124 | Submission Open

Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Pathophysiology and Molecular Mechanisms of Cardiovascular, Cardiometabolic, and Cardiorenal Diseases

edited by

Carmine Savoia

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3085 | Submission Open

Keywords: heart failure; cardiorenal syndrome; oxidative stress; inflammation; endothelial dysfunction; fibrosis and remodeling; mitochondrial function and energy metabolism; insulin resistance; epigenetics and microRNAs; biomarkers and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Relationship Between Plant Microbiome and Immunity

edited by

Sergio Molinari

submission deadline 20 Sep 2026 | 1 articles | Viewed by 3048 | Submission Open

Keywords: microbiome; plant immune system; rhizosphere of plant roots; microbe-associated molecular patterns (MAMPs)

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia

edited by Fabrizio Barbetti

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3016 | Submission Open

Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plasma-Based Technologies for Food Safety and Health Enhancement

edited by

Ihn Han

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2986 | Submission Open

Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation

(This special issue belongs to the Section Biochemistry)

Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition

edited by

Bruna Scaggiante

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2935 | Submission Open

Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing

(This special issue belongs to the Section Molecular Oncology)

The Differential Role of B Cells in Autoimmune Diseases: From Autoantibodies to Antigen Presentation

edited by

Markus C. Kowarik

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2622 | Submission Open

Keywords: autoantibodies; B cells; antigen presentation; B cell functions; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Current Advances in Immuno-Oncology

edited by Gratiela Grădișteanu Pircălabioru

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2619 | Submission Open

Keywords: immuno-oncology; tumor microenvironment; immune checkpoint inhibitors; CAR-T cells; adoptive cell therapy; cancer vaccines; oncolytic viruses; tumor immune evasion; immunometabolism; biomarkers; tumor immunology; microbiome and cancer

(This special issue belongs to the Section Molecular Oncology)

Neuromodulatory Effects of Serotonin, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2508 | Submission Open

Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Synapse: Diversity, Function and Signaling

edited by Leonora Balaj

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2483 | Submission Open

Keywords: synaptic signaling; synaptic plasticity; brain disorders; synapse diversity; molecular composition of synapse

(This special issue belongs to the Section Molecular Neurobiology)

The Regulation of Microorganisms on Human Endocrine and Metabolic Systems

edited by Thi Phuong Nam Bui and Valentina Tremaroli

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2454 | Submission Open

Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases

(This special issue belongs to the Section Molecular Microbiology)

Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry

edited by

Robert O'Reilly

submission deadline 20 Sep 2026 | 3 articles | Viewed by 2432 | Submission Open

Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia

edited by Anna Sicuranza

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2384 | Submission Open

Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Trace Elements in Nutrition and Health, 2nd Edition

edited by Jie Feng

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2321 | Submission Open

Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism of Immune Response

edited by Marisa Mariel Fernández

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2300 | Submission Open

Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity

(This special issue belongs to the Section Molecular Immunology)

Advanced Research in Veterinary Drugs

edited by Jianyong Li

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2266 | Submission Open

Keywords: veterinary drug; target; chemical structure; mechanism; medicinal chemistry; toxicity; pharmacodynamics; pharmacokinetics; residues

(This special issue belongs to the Section Molecular Pharmacology)

Contribution of Astrocytes and Microglia for the Development of Neurological Disorders

edited by

Rommy Von Bernhardi

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2233 | Submission Open

Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2222 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

Advances in Vitiligo: From Mechanisms to Treatment Innovations

edited by Hyun Jeong Ju

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2210 | Submission Open

Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Spectral Control of Stress Response in Plants

edited by

Gábor Kocsy

and Zsolt Gulyás

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2172 | Submission Open

Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Kidney Diseases: Molecular Research and Novel Therapies

edited by Niels Olsen Saraiva Camara

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2137 | Submission Open

Keywords: kidney disease; immunology and inflammation; zebrafish models; therapeutic targets; modern-era drivers of renal pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Zoonotic Diseases: Current Advances and Perspectives

edited by

Gabriela Goujgoulova

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2119 | Submission Open

Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Interactions and Advanced Computational Methods for Biomolecular Systems

edited by

Amar Singh

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2114 | Submission Open

Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques

(This special issue belongs to the Section Molecular Biophysics)

Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources

edited by

Elena Dreassi

and

Annalaura Brai

submission deadline 20 Sep 2026 | 3 articles | Viewed by 2086 | Submission Open

Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Antimicrobial Resistance

edited by

Maria Teresa Mascellino

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2080 | Submission Open

Keywords: drug resistance; microorganisms; molecular mechanisms; mobile genetic elements; CRISPR/Cas9; nucleic acid hybriditation; probes; LAMP

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research and Utilization of Environmental Microbial Resources

edited by

Hikmate Abriouel

submission deadline 20 Sep 2026 | 4 articles | Viewed by 2071 | Submission Open

Keywords: environmental microbiology; molecular microbial resources; microbial metabolites; microbial diversity; microbial ecology; bioremediation; agricultural microbiology; omics technologies; biofilm formation; microbiome applications

(This special issue belongs to the Section Molecular Microbiology)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2047 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Bioinformatics in Human Disease

edited by Maria Rosaria De Filippo

submission deadline 20 Sep 2026 | 3 articles | Viewed by 2025 | Submission Open

Keywords: bioinformatics; omics data; machine learning; biomarker prediction

(This special issue belongs to the Section Molecular Informatics)

Genetic Advances in Neurobiology of Health and Disease

edited by

Efthimios M. C. Skoulakis

and Katerina Papanikolopoulou

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2018 | Submission Open

Keywords: genomics; proteins; proteomics; signaling

(This special issue belongs to the Section Molecular Neurobiology)

Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1962 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1952 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Pharmacology of Protein Kinase Inhibitor

edited by

Liming Hu

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1770 | Submission Open

Keywords: protein kinase inhibitor; molecular pharmacology; signaling pathway; preclinical/clinical evaluation; computational modeling; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Oxidation Processes and Biodegradation for Emerging Contaminants Treatment: 2nd Edition

edited by

Chengdu Qi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1744 | Submission Open

Keywords: advanced oxidation processes; persistent organic compounds; water pollution control; biodegradation; emerging contaminants; water treatment; wastewater treatment; toxicity assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advanced Functionalization of Biopolymers and Bio-Oligomers for Precision Therapeutics

edited by

Dayong Wang

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1740 | Submission Open

Keywords: precision therapeutics; biopolymers; drug delivery; biopharmaceuticals; pharmacology

(This special issue belongs to the Section Materials Science)

Antioxidants: Design, Synthesis, and Mechanism of Actions

edited by Choon Young Lee

submission deadline 20 Sep 2026 | 3 articles | Viewed by 1722 | Submission Open

Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator

(This special issue belongs to the Section Macromolecules)

Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application

edited by Nenad Filipovic

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1716 | Submission Open

Keywords: hydrazones; (thio/seleno)semicarbazones; oximes; antimicrobial activity; anticancer activity; enzyme inhibition; metal complexes; diagnostic agents; photothermal therapy; photodynamic therapy

(This special issue belongs to the Section Biochemistry)

Advanced Research on Nanosensors for Molecular Sensing Applications

edited by

Giorgio Rispoli

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1676 | Submission Open

Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor

(This special issue belongs to the Section Molecular Nanoscience)

New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition

edited by

Ramón Cacabelos

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1629 | Submission Open

Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Brain–Immune Crosstalk and Ischemic Injury

edited by

Yvonne Couch

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1618 | Submission Open

Keywords: stroke; ischemia; haemorrhage; inflammation; cytokines; macrophages; neutrophils; microglia; immunity

(This special issue belongs to the Section Molecular Immunology)

Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies

edited by

Mohammad Ejaz Ahmed

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1606 | Submission Open

Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond Drivers and Suppressors: Investigating Upstream Regulators of Cell Death

edited by

Damian Kołat

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1605 | Submission Open

Keywords: cell death; driver genes; suppressor genes; upstream regulators; gene expression; in silico; in vitro; in vivo

(This special issue belongs to the Section Molecular Biology)

Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management—2nd Edition

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1597 | Submission Open

Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

From Plant Genomics Investigations to Plant Biotechnology Exploitation

edited by

Maria R. Ercolano

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1576 | Submission Open

Keywords: sequencing; plant genomes; biotechnological applications; translational genomics; new discoveries

(This special issue belongs to the Section Molecular Plant Sciences)

Updates on Metal Ions and Related Complexes in Molecular Biology and Biochemistry

edited by

Makan Golizeh

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1565 | Submission Open

Keywords: biochemistry; homeostasis; metal ions; metal ion complexes; metallomics; molecular biology; molecular pathogenesis; quantification; systems biology; toxicity

(This special issue belongs to the Section Biochemistry)

Displaying special issue 1601-1650 on page 33 of 64.

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