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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation

edited by Rossana Scuri

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4399 | Submission Open

Keywords: arteriolar networks organization; blood flow supply; cardiovascular disease; endothelial dysfunction; eNOS regulatory activity; oxidative stress; polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4388 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Advancements in Alzheimer’s Disease Treatment: Exploring Novel Approaches and Strategies

edited by

Sunmin Park

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4382 | Submission Open

Keywords: Alzheimer’ s disease; bioinformatics; novel compounds; in vitro; in vivo; clinical study; Alzheimer’ s disease models

(This special issue belongs to the Section Molecular Neurobiology)

Endometriosis and Infertility

edited by Ludwig Kiesel

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4366 | Submission Open

Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

FTIR Miscrospectroscopy: Opportunities and Challenges

edited by Simona Sabbatini

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4336 | Submission Open

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Developments in Omics Technologies Applied to Oncology Research

edited by

Simona D’Aguanno

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4302 | Submission Open

Keywords: single‑cell genome sequencing; single‑cell epigenome sequencing; single‑cell CRISPR sequencing; imaging mass cytometry; RNAscope; digital spatial profiling; multiplex IHC; multiplex IF; omics technologies

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Pathophysiology of Diabetes, Hypertension and Cardiovascular Diseases

edited by Alessandro Durante

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4269 | Submission Open

Keywords: diabetes; hypertension; cardiology; cardiovascular diseases; coronary artery diseases; athero-sclerosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Coronavirus Disease (COVID-19): Pathophysiology (6th Edition)

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4097 | Submission Open

Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapeutic Targets for Neuroinflammation and Neurodegeneration

edited by Muhammad Sohail Khan and

Cassie S. Mitchell

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4054 | Submission Open

Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations

(This special issue belongs to the Section Molecular Neurobiology)

New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition

edited by

Ilaria Giusti

and

Celeste Caruso Bavisotto

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4034 | Submission Open

Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Cognitive Dysfunction from COVID-19 Infection and Other Respiratory Viruses

edited by

Abdullah Mosabbir

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3907 | Submission Open

Keywords: long COVID; post-COVID; cognitive dysfunction; virus; cognition; brain; viral infection; virol-ogy; RNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genome Structure, Function and Dynamic Regulation of Cell Fate

edited by Georg Hildenbrand and

Michael Hausmann

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3891 | Submission Open

Keywords: genome structure and organization; DNA sequence patterning and functional genomics; epigenetic regulation and chromatin remodeling; DNA damage response and cellular developments; cellular differentiation and cell fate; transcriptional control; chromatin architecture

(This special issue belongs to the Section Molecular Genetics and Genomics)

Lignocellulose Bioconversion and High-Value Utilization

edited by

Jian Zhao

submission deadline 20 Nov 2025 | 5 articles | Viewed by 3838 | Submission Open

Keywords: lignocellulosic biomass; including seed husks from grains; enzymes; microorganisms producing enzymes; chemical catalysts; biomass conversion; biofuels; bioproducts; fermentable sugars; biomass-based functional materials; lignocellulose nanoparticles

(This special issue belongs to the Section Macromolecules)

Advances in Organic Synthesis in Drug Discovery

edited by

Laura Gabriela Sârbu

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3826 | Submission Open

Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization

(This special issue belongs to the Section Molecular Pharmacology)

Editorial Board Members’ Collection Series: “Protein Biophysics”

edited by

Vladimir N. Uversky

and

Assaf Friedler

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3761 | Submission Open

Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics)

Hematological Malignancies: Molecular Mechanisms and Therapy, 2nd Edition

edited by

Stella Bouziana

submission deadline 20 Nov 2025 | 4 articles | Viewed by 3738 | Submission Open

Keywords: hematological malignancies; molecular pathways; genetics; immunopathogenesis; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Epigenetic Analyses in Cancer

edited by Jing Gong

submission deadline 20 Nov 2025 | 4 articles | Viewed by 3657 | Submission Open

Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Response to Drought, Heat, and Light Stress

edited by Mengzhu Lu and Shijiang Cao

submission deadline 20 Nov 2025 | 4 articles | Viewed by 3645 | Submission Open

Keywords: plant stress response; molecular biology techniques; bioinformatics; genetic mechanisms; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Therapeutic Potential of Natural Compounds: Insights into Mechanisms, Molecular Docking, and Biological Activities, 2nd Edition

edited by

Rafał Hałasa

and

Katarzyna Turecka

submission deadline 20 Nov 2025 | 5 articles | Viewed by 3453 | Submission Open

Keywords: natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; therapeutic potential; anticancer; antimicrobial; antiviral; anti-civilization diseases; antiobesity; antidiabetes; preventing the development of cardiovascular diseases; including myocardial infarction; hypertension and ischemic heart disease; food hypersensitivity; antiallergy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer

edited by

Isabel Fabregat

and

Gianluigi Giannelli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3426 | Submission Open

Keywords: TGF-beta; fibrosis; inflammation; cancer; immune cells; fibroblasts; EMT; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Deciphering Molecular Complexity of Pancreatic Cancer

edited by

Dimitrios H. Roukos

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3241 | Submission Open

Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology of Soybean

edited by Zhengjun Xia

submission deadline 20 Nov 2025 | 5 articles | Viewed by 3192 | Submission Open

Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Perspectives in Lung Diseases: Pathogenesis, Diagnosis, and Treatment

edited by

Elena Levantini

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3104 | Submission Open

Keywords: lung cancer models; cancer stem cells; tumor microenvironment; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics

edited by

Ivano Condò

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3052 | Submission Open

Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets

edited by Jue Wang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3040 | Submission Open

Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular Oncology)

Natural Products and Synthetic Compounds for Drug Development: 3rd Edition

edited by

Guan-Jhong Huang

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2978 | Submission Open

Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease

(This special issue belongs to the Section Molecular Pharmacology)

Therapeutics and Pathophysiology of Cognitive Dysfunction

edited by

Maheedhar Kodali

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2949 | Submission Open

Keywords: cognition; neurologic diseases; neuroinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2946 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances and Perspectives of Lung Disease: 2nd Edition

edited by

Longshuang Huang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2943 | Submission Open

Keywords: lung disease; inflammation; regeneration; infection; drug discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pharmacology and Toxicology of Synthetic and Natural Products

edited by

Sherif T.S. Hassan

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2920 | Submission Open

Keywords: pharmacology and toxicology; pharmacodynamics and pharmacokinetics; synthetic drugs; natural products; drug interactions; molecular mechanisms; therapeutic potential; adverse effects; dose– response relationship; drug safety and efficacy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Plant–Environment Interactions

edited by

Magdalena Pawełkowicz

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2874 | Submission Open

Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights in Plant Cell Biology

edited by

Jacek Z. Kubiak

and

Malgorzata Kloc

submission deadline 20 Nov 2025 | 4 articles | Viewed by 2831 | Submission Open

Keywords: chloroplasts; cell wall; vacuoles; microtubule cytoskeleton; plant-cell-specific structures

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling Apoptosis: Deciphering Molecular Mechanisms

edited by

Gabriella Simbula

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2757 | Submission Open

Keywords: apoptosis; development; microenvironment; mitochondria dysfunction; molecular mechanisms; tumors; degenerative diseases; diabetes; metabolic diseases; neurodegenerative disease; novel pharmacological strategies

(This special issue belongs to the Section Biochemistry)

Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases

edited by

Bartłomiej Tomasz Ferra

and Anna Lass

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2747 | Submission Open

Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques

(This special issue belongs to the Section Molecular Microbiology)

Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

edited by

Julita Kulbacka

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2713 | Submission Open

Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI

(This special issue belongs to the Section Molecular Oncology)

The Effects of Dietary Supplements, Functional Foods and Nutraceuticals in the Immune System

edited by

Kaleta Beata

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2711 | Submission Open

Keywords: dietary supplements; functional foods; immune system; immunomodulation; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Pathogenesis and Treatment of Pregnancy Complications

edited by

Melissa Wilson

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2700 | Submission Open

Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2667 | Submission Open

Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Pain: From Molecular Basis to Therapy

edited by Samuel J. Lin

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2633 | Submission Open

Keywords: pain mechanisms; molecular signaling; neurotransmitters; ion channels; genetic predisposition; epigenetic regulation; immune– neuron interaction; pharmacological therapy; gene therapy; neuromodulation; regenerative medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Potential Effects of Medicinal Plants

edited by

Guan-Jhong Huang

submission deadline 20 Nov 2025 | 4 articles | Viewed by 2615 | Submission Open

Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Diagnosis and Latest Treatment for Gastric Cancer

edited by

Petra Hudler

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2612 | Submission Open

Keywords: gastric cancer; biomarkers; genetics; epigenetics; immunotherapy; molecular diagnostics; personalized medicine; predisposition; risk factors

(This special issue belongs to the Section Molecular Oncology)

Multi-Omics Analysis and Application of Plant Natural Products (2nd Edition)

edited by

Qiang Zhang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2574 | Submission Open

Keywords: omics; plant components; bioactivity; signaling; pathway; target; mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic Testing in Molecular Pathology and Diagnosis

edited by

Marco Fabiani

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2558 | Submission Open

Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management

(This special issue belongs to the Section Molecular Biology)

Molecular Design of Artificial Receptors Using Virtual Approaches

edited by Houjin Zhang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2555 | Submission Open

Keywords: artificial receptors; protein design; computational biology; drug targeting; biosensors; tissue engineering; synthetic biology

(This special issue belongs to the Section Molecular Biophysics)

Molecular Research in Cardiovascular Disease, 3rd Edition

edited by

Maria Dorobantu

and

Alexandru Scafa-Udriste

submission deadline 20 Nov 2025 | 4 articles | Viewed by 2541 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; endothelial cells; matrix metalloproteinases; biomarkers; miRNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Dynamics, Binding and Allostery

edited by

Beatriz Ibarra-Molero

Raquel Godoy-Ruiz

and

Encarnación Medina Carmona

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2522 | Submission Open

Keywords: proteins dynamics; enzyme catalysis; conformational changes; allosteric regulation; signal transduction; neurodegenerative disorders; cancer; computational methods; therapeutic interventions

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis

edited by

Michele Marchioni

and

Luigi Schips

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2517 | Submission Open

Keywords: molecular pathogenesis; renal cell carcinoma; genomic profiling; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Burn and Wound Healing

edited by

Alisha R. Oropallo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2498 | Submission Open

Keywords: burn; wound; molecular mechanisms; cell signaling; growth factors; cytokines; extracellular matrix; angiogenesis; healing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2456 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Biomarkers in Ischemic Stroke

edited by Hanna Pawluk and

Renata Kołodziejska

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2421 | Submission Open

Keywords: stroke; brain tissue damage; ischemic stroke; inflammatory markers; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1601-1650 on page 33 of 70.

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