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Updates on Metal Ions and Related Complexes in Molecular Biology and Biochemistry

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 March 2026 | Viewed by 108

Special Issue Editor


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Guest Editor
1. Department of Environmental and Physical Sciences, Faculty of Science, Concordia University of Edmonton, Edmonton, AB, Canada
2. Metals in Environment and Health (MEH) Research Cluster, Concordia University of Edmonton, Edmonton, AB, Canada
Interests: metals in chemical biology and medicine; computational biochemistry and bioinformatics

Special Issue Information

Dear Colleagues,

From enzymatic reactions to cellular communication and immunity, metal ions and their complexes play a crucial role in biological processes. Metals like iron and copper are essential to most life forms but can cause toxicity if not intricately controlled by the cell. Complexation facilitates the absorption, transportation, and excretion of metal ions and is key to metal homeostasis in living organisms. Studying metals at the cellular and molecular levels can improve our understanding of the delicate yet fundamental interactions between metal ions, humans, and life itself.  

This Special Issue focuses on metal ions and related complexes in molecular biology and biochemistry. We welcome research and review articles in the following subjects: Biomedical applications of metal ions and metal ion complexes, delivery of essential metals to humans and other organisms, metal ion absorption and homeostasis, metal ion transport and storage, metal ions and other molecules in biological systems (e.g., metallomics, metallometabolomics, metalloproteomics), metal poisoning and detoxification, metal ion quantification in biological samples, and molecular pathology of metal-related diseases.

Researchers in agricultural and environmental sciences, food and nutritional sciences, medical sciences, and public health, who explore the molecular biology and biochemistry of metals, are also encouraged to submit their work.

Dr. Makan Golizeh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biochemistry
  • homeostasis
  • metal ions
  • metal ion complexes
  • metallomics
  • molecular biology
  • molecular pathogenesis
  • quantification
  • systems biology
  • toxicity

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Published Papers (1 paper)

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Research

17 pages, 3536 KB  
Article
Protective Effect of PEG-EDTA and Its Zinc(II) Complex on Human Cells
by Tashneet Dhaliwal, Cole Babcock, Brynmar Degenhardt, Isaac Osorio Passos, Tigran Stepanyan and Makan Golizeh
Int. J. Mol. Sci. 2026, 27(1), 44; https://doi.org/10.3390/ijms27010044 (registering DOI) - 20 Dec 2025
Abstract
The most widely used chelating agent, ethylenediaminetetraacetic acid (EDTA), can cause mild to serious side effects when used for clinical applications. Introducing a polyethylene glycol (PEG) moiety into the molecular structure of EDTA has been shown to lower its toxicity; however, it is [...] Read more.
The most widely used chelating agent, ethylenediaminetetraacetic acid (EDTA), can cause mild to serious side effects when used for clinical applications. Introducing a polyethylene glycol (PEG) moiety into the molecular structure of EDTA has been shown to lower its toxicity; however, it is unclear whether this could affect EDTA chelation efficiency due to the steric hindrance and the loss of a coordination site caused by the PEGylation reaction. This research aimed to determine if PEGylation could reduce EDTA toxicity without affecting its chelation efficiency. To this end, effective formation constants were determined for EDTA and PEG-EDTA rare earth metal ion complexes using spectrophotometric and titrimetric methods. The stability of PEG-EDTA complexes with the target metal ions was assessed under different conditions using Fourier-transform infrared spectroscopy. The cytotoxicity and metal detoxification capacity of EDTA, PEG-EDTA, and their zinc(II) complexes were determined in two selected human cell types exposed to toxic heavy metal ions. This study suggests that PEG-EDTA has lower toxicity than EDTA, especially when complexed with a nontoxic metal ion, such as zinc(II), while only slightly losing chelation efficiency, potentially making PEG-EDTA a more favourable metal detoxification reagent for clinical applications. Full article
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