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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Diseases: Molecular Mechanisms, Biomarkers, and Therapies submission deadline 20 Sep 2024 | 4 articles | Viewed by 5923 | Submission Open
Keywords: cardiovascular diseases; oxidative stress; inflammation; risk factors; biomarkers; omics technology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Heavy Metal Toxicity: Molecular Mechanisms and Potential Therapies
edited by
submission deadline 20 Sep 2024 | 4 articles | Viewed by 5893 | Submission Open
Keywords: heavy metals; wildlife exposures; human exposure; metal toxicity; contamination; hexavalent chromium; nickel; lead; arsenic; cadmium; uranium; tungsten
(This special issue belongs to the Section Molecular Toxicology)
Molecular Advances in Oncologic Photodynamic Therapy
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 5721 | Submission Open
Keywords: oncology; photodynamic therapy; photosensitizer; targeted drug delivery system; photonanomedicines; phototoxicity; photo cytotoxicity; dark toxicity; superficial tumors; intracellular delivery and localization; anti-tumor immunity; bioinformatics analysis; therapy-induced tumor cell death; stemness of cancer cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Depression: From Molecular Basis to Therapy
edited by
submission deadline 20 Sep 2024 | 7 articles | Viewed by 5711 | Submission Open
Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers
(This special issue belongs to the Section Molecular Neurobiology)
Epigenetic Mechanisms and Human Pathology 4.0 submission deadline 20 Sep 2024 | 5 articles | Viewed by 5610 | Submission Open
Keywords: epigenetics; human pathology; cancer; DNA methylation; npcRNA; histone modification; personalized therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Activation of the Blood–Brain Barrier and Neurological Dysfunction
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 5515 | Submission Open
Keywords: blood– brain barrier; neuro-infectious diseases; cerebral malaria; Plasmodium; cerebral vasculature; vascular heterogeneity; white matter; gray matter
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Gene and Cell Therapy 2.0 submission deadline 20 Sep 2024 | 3 articles | Viewed by 5432 | Submission Open
Keywords: gene therapy; cell therapy; immunotherapy; RNA; genome editing; vectorology
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Physiology Associated with the Blood–Brain Barrier
edited by
submission deadline 20 Sep 2024 | 5 articles | Viewed by 5384 | Submission Open
Keywords: blood– brain barrier; neurodegenerative diseases; cancer; diet; pharmacology; transporters; receptors; microglial cells; tanycytes; fenestrated vessels; hypothalamus; plasticity
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Thrombosis
edited by
submission deadline 20 Sep 2024 | 4 articles | Viewed by 5382 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gene Doping Control in Human and Animal Sports
edited by
submission deadline 20 Sep 2024 | 5 articles | Viewed by 5374 | Submission Open
Keywords: cell therapy; cell doping; gene doping; gene editing; gene silencing; gene therapy; transgene; CRISPR; therapeutic oligonucleotide
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Cardiovascular Risk Factors
edited by
submission deadline 20 Sep 2024 | 5 articles | Viewed by 5361 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
Cancer Genomics submission deadline 20 Sep 2024 | 3 articles | Viewed by 4831 | Submission Open
Keywords: precision oncology; cancer genomics; personalized medicine; mutagenesis; molecular epidemiology
(This special issue belongs to the Section Molecular Oncology)
Mitochondria-Mediated Oxidative Stress in Diseases: Cell Death and Treatment submission deadline 20 Sep 2024 | 4 articles | Viewed by 4790 | Submission Open
Keywords: mitochondrial dysfunction; reactive oxygen species; oxidative stress; mitochondrial biogenesis; mitotherapy; neurodegenerative diseases; cardiovascular diseases; cancer; biomarkers; mitochondrial dynamics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Abiotic Stress Signaling in Plants: Focus on Atmospheric Stressors submission deadline 20 Sep 2024 | 6 articles | Viewed by 4723 | Submission Open
Keywords: abiotic stress; interactomics; gene expression regulation; kinases; oxidative stress; phytohormones; signaling; sugar sensing and signaling; transcription factors
(This special issue belongs to the Section Molecular Plant Sciences)
New Molecular Insights into Ischemia/Reperfusion
edited by
submission deadline 20 Sep 2024 | 5 articles | Viewed by 4680 | Submission Open
Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Polyphenols and Their Transformation Products: Properties and Mechanism of Action submission deadline 20 Sep 2024 | 4 articles | Viewed by 4630 | Submission Open
Keywords: polyphenols; transformation products; Biological activity; cytotoxic effects; mechanism of action; health effect
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mesenchymal Stem Cells and Their Therapeutic Application 2.0
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 4582 | Submission Open
Keywords: mesenchymal stem cells; regenerating tissue; anti-cancer therapies; therapeutic applications
(This special issue belongs to the Section Molecular Biology)
Targeting of Functional Proteins in Disease Therapeutics: Enzyme Function and Inhibition Studies submission deadline 20 Sep 2024 | 4 articles | Viewed by 4567 | Submission Open
Keywords: enzymes; disease therapeutics; inhibitior
(This special issue belongs to the Section Biochemistry)
Sarcomeric Proteins in Health and Disease 3.0
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 4565 | Submission Open
(This special issue belongs to the Section Molecular Biophysics)
Cutting Edge Advances in Prostate Cancer submission deadline 20 Sep 2024 | 3 articles | Viewed by 4541 | Submission Open
Keywords: prostate cancer; prognostic and diagnostic biomarkers; therapy resistance; tumor microenvironment; molecular biology
(This special issue belongs to the Section Molecular Oncology)
Anticancer Activity of Natural Products and Related Compounds submission deadline 20 Sep 2024 | 4 articles | Viewed by 4519 | Submission Open
Keywords: anticancer agent; natural product chemistry; isolation and structure elucidation; medicinal chemistry; molecular mechanism; targeted therapy; structure– activity relationships; phytochemistry; chemical biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Update on Immunotherapies for Cancer submission deadline 20 Sep 2024 | 3 articles | Viewed by 4400 | Submission Open
Keywords: cell therapies; monoclonal antibodies; molecular adjuvants; oncolytic therapies; immunogenic; chemotherapy and radiotherapy; cancer vaccines; immunodominance; neoantigens; clinical trials; tumor immune microenvironment
(This special issue belongs to the Section Molecular Oncology)
Design, Synthesis, and Modification of Efficient Catalyst Materials submission deadline 20 Sep 2024 | 5 articles | Viewed by 4263 | Submission Open
Keywords: surface modification; heterogeneous and homogenous catalysis; surface/texture chemistry; physicochemical characterization of catalytic materials; the applications of catalysts; for example; in environmental processes
(This special issue belongs to the Section Materials Science)
Immunomodulatory Molecules in Cancer
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 4126 | Submission Open
Keywords: cancer; immunomodulatory molecules; mechanism of action; immune system; small-molecule probes; activation/inhibition; biological activity
(This special issue belongs to the Section Molecular Immunology)
The Role of Glycosaminoglycans in Human Diseases
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 4095 | Submission Open
Keywords: glycosaminoglycans; inflammation; infectious disease; cancer
(This special issue belongs to the Section Biochemistry)
Bioactive Natural Compounds: Protecting Plants and Promoting Human Health submission deadline 20 Sep 2024 | 4 articles | Viewed by 4084 | Submission Open
Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Approaches to Male Infertility: From Diagnosis to Decision-Making submission deadline 20 Sep 2024 | 3 articles | Viewed by 4074 | Submission Open
Keywords: male infertility; sperm; omics; epigenome; transcriptome; proteome; metabolome; assisted reproductive technique (ART)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cellular and Molecular Regulatory Signals in Root Growth and Development
edited by
submission deadline 20 Sep 2024 | 4 articles | Viewed by 4008 | Submission Open
Keywords: reactive oxygen species; water supply and deficit; root apoplastic barriers; root architecture; nutrients uptake
(This special issue belongs to the Section Molecular Plant Sciences)
Techniques and Strategies in Drug Design and Discovery, 2nd Edition submission deadline 20 Sep 2024 | 6 articles | Viewed by 3999 | Submission Open
Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
New Challenges and Perspectives in Polycystic Ovary Syndrome
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 3959 | Submission Open
Keywords: polycystic ovary syndrome; evolutionary origins; developmental origins; pathogenesis; pathophysiology; microbiome; pregnancy complications; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research on Antimicrobial Agents
edited by and
submission deadline 20 Sep 2024 | 4 articles | Viewed by 3928 | Submission Open
Keywords: antimicrobial; antibiotic; multidrug resistant microorganisms; natural products; byproducts; biofilms
(This special issue belongs to the Section Molecular Pharmacology)
Metabolic Regulation in the Development of Cardiovascular Disease and Heart Failure 2.0
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 3862 | Submission Open
Keywords: diabetes; metabolism; dyslipidemia; cardiovascular disease; heart failure; diagnosis; prognosis; therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Herpesviruses
edited by
submission deadline 20 Sep 2024 | 4 articles | Viewed by 3779 | Submission Open
(This special issue belongs to the Section Molecular Microbiology)
Advances in Molecular Biology and Treatment of Thymic Epithelial Tumors
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 3735 | Submission Open
Keywords: thymic epithelial tumors; thymomas; tumor biology; pathogenesis; carcinogenesis; biomarkers; tumor microenvironment; targeted therapy; predictive markers
(This special issue belongs to the Section Molecular Oncology)
Computational Modelling and Molecular Dynamics Simulations of Biological Systems
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 3677 | Submission Open
Keywords: molecular dynamics simulations; coarse-graining approaches; computational biophysics; agent-based modeling; mechanistic modeling; multiscale modeling; machine learning; protein structure and function
(This special issue belongs to the Section Molecular Informatics)
Molecular Aspects of Adrenal Diseases and Carcinoma
edited by Tamás Micsík
submission deadline 20 Sep 2024 | 4 articles | Viewed by 3650 | Submission Open
Keywords: adrenal neoplasia; adrenocortical cancer; molecular and genetics; omics; artificial intelligence digital pathology; individualized therapy; prognostication
(This special issue belongs to the Section Molecular Oncology)
Novel Pharmacology of Diabetic Complications
edited by and Richard Hulse
submission deadline 20 Sep 2024 | 1 articles | Viewed by 3617 | Submission Open
Keywords: diabetes mellitus; complication; pathophysiology; mechanism; therapeutic strategies
(This special issue belongs to the Section Molecular Pharmacology)
Targeted Therapy for Immune Diseases
edited by
submission deadline 20 Sep 2024 | 5 articles | Viewed by 3609 | Submission Open
Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Genetic and Molecular Mechanisms of Resistance or Adaptation to Abiotic Stress in Plants
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 3575 | Submission Open
(This special issue belongs to the Section Molecular Plant Sciences)
From Molecular Insights to Novel Therapies: Neurological Diseases
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 3508 | Submission Open
Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation
(This special issue belongs to the Section Molecular Neurobiology)
Cyclodextrins: Properties and Applications, 2nd Edition submission deadline 20 Sep 2024 | 4 articles | Viewed by 3174 | Submission Open
Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties
(This special issue belongs to the Section Macromolecules)
New Diagnostic Tools and Biomarkers in Oncological Diseases 2.0
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 3014 | Submission Open
Keywords: oncologic diseases; biomarkers; liquid biopsy; miRNA; ncRNA; exosomes
(This special issue belongs to the Section Molecular Oncology)
Advances in Research on Neurogenesis 3.0 submission deadline 20 Sep 2024 | 3 articles | Viewed by 2992 | Submission Open
Keywords: adult neurogenesis; neurodegeneration; aging; psychiatric disorders; cognition; regeneration; adult neurogenesis evolution
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Computational Research in Pharmacological and Toxicological Issues
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 2964 | Submission Open
Keywords: in silico study; computational toxicology; adverse drug reaction; drug discovery; QSAR analysis; machine learning; artificial intelligence
(This special issue belongs to the Section Molecular Informatics)
New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization and Applications
edited by and Yi Wan
submission deadline 20 Sep 2024 | 1 articles | Viewed by 2938 | Submission Open
Keywords: nanoparticles; nanozymes; fluorescent nanoparticles; aggregates of nanoparticles; antibody; aptamer; nanoparticle– bioreceptor conjugates; protein corona; nanoparticle-based biosensors; enhanced immunoassays; isothermal amplification; nanoparticle-based therapy; nanoparticle-based delivery; nanotheranostics
(This special issue belongs to the Section Molecular Nanoscience)
Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?
edited by
submission deadline 20 Sep 2024 | 3 articles | Viewed by 2914 | Submission Open
Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Current Advances in Novel Antiviral Drugs
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 2889 | Submission Open
Keywords: broad-spectrum antivirals; antiviral mechanisms; non-nucleoside antivirals; antiviral resistance; emerging viruses
(This special issue belongs to the Section Molecular Pharmacology)
Applications of Mesenchymal Stem Cells in Neuroscience 2.0 submission deadline 20 Sep 2024 | 1 articles | Viewed by 2758 | Submission Open
Keywords: mesenchymal stem cells; extracellular vesicles; microvesicles; exosomes; neurodegenerative diseases; neurological conditions  ; inflammation  ; cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Gastrointestinal: Inflammation, Immunity and Cancer Pathways
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 2729 | Submission Open
Keywords: inflammation and cancer biology; infectious agents; post-translational modification; signaling pathway; apoptosis; autophagy; necrosis; necroptosis; innate immunity; host– pathogens interactions; cell proliferation; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research in Antimicrobial Natural Products
edited by Jose Javier Sanz Gomez
submission deadline 20 Sep 2024 | 3 articles | Viewed by 2636 | Submission Open
Keywords: natural products; chemical composition; spoilage microorganisms; pathogens; food preservatives; biofilms; safety assessment; clean label; antibiotics resistance
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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