Brain–Immune Crosstalk and Ischemic Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 32
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue aims to focus on the dynamic interactions between the central nervous system and the immune system in the context of ischemic injury. We aim to explore how immune responses influence brain damage and recovery following ischemic events, such as stroke, and how neural signals modulate systemic and local immune activity.
We aim to collate cutting-edge research elucidating the mechanisms of brain–immune crosstalk in ischemic injury, highlighting translational insights that could inform novel therapeutic strategies for neuroprotection, inflammation modulation, and functional recovery.
Potential topics of interest include the following:
- Innate and adaptive immune responses following cerebral ischemia or haemorrhage;
- Microglia and astrocyte contributions to post-ischemic inflammation;
- Peripheral immune cell trafficking to the brain after stroke;
- Cytokine and chemokine signalling in ischemic injury;
- Neurovascular unit disruption and immune interactions;
- Immune modulation as a therapeutic approach for ischemic injury;
- Biomarkers linking immune activity to stroke severity and outcomes;
- Neuroimaging and spatial mapping of immune activity post-ischemia;
- Sex differences and age-related variations in brain–immune responses;
- Preclinical models vs. human studies of post-ischemic immune dynamics.
Dr. Yvonne Couch
Guest Editor
Manuscript Submission Information
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Keywords
- stroke
- ischemia
- haemorrhage
- inflammation
- cytokines
- macrophages
- neutrophils
- microglia
- immunity
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