Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 32
Special Issue Editor
Special Issue Information
Dear Colleagues,
Schiff bases are bioactive molecules, with 41 approved for therapeutic use as antimicrobial, cardiovascular, gastrointestinal, and CNS drugs. They form metal complexes in which metals introduce properties inaccessible to pure organic compounds, such as additional coordination numbers, redox behaviour, and, in some cases, radioactivity and paramagnetism. Therefore, Schiff base metal complexes show different reactivity and, consequently, new modes of action that often result in better activity than their organic counterparts. They can also be activated by external stimuli such as electromagnetic radiation, sound, and heat. Such properties enable their use not only in the treatment but also in the diagnosis of various diseases.
In this Special Issue, we welcome original studies on all aspects related to the advancement of Schiff bases and their metal complexes as bioactive and diagnostic agents for therapeutic and pharmaceutical uses. The Issue will also cover reports dealing with clinical or pure model submissions involving biomolecular experiments.
Dr. Nenad Filipovic
Guest Editor
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Keywords
- hydrazones
- (thio/seleno)semicarbazones
- oximes
- antimicrobial activity
- anticancer activity
- enzyme inhibition
- metal complexes
- diagnostic agents
- photothermal therapy
- photodynamic therapy
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