Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 73
Special Issue Editor
Interests: neutrophil extracellular traps (nets); immunology
Special Issue Information
Dear Colleagues,
Neutrophil extracellular traps (NETs) are web-like structures composed of DNA, histones, and granule proteins and are released by neutrophils as part of the innate immune response. While they were initially identified as a defense mechanism against pathogens, NETs have been implicated in the pathogenesis of a wide range of diseases, including cancer, autoimmune conditions, thrombosis, and chronic inflammation.
Recent advances have begun to unravel the molecular and cellular mechanisms regulating NET formation. However, many aspects of NET biology remain poorly understood, particularly their roles in shaping disease microenvironments, modulating immune responses, and driving tissue damage and therapeutic resistance.
This Special Issue invites original research articles and comprehensive reviews that expand our understanding of NETs in health and disease. We welcome submissions addressing NET biology, molecular regulation, disease associ ations, biomarker discovery, and therapeutic strategies. A central aim is to promote the translation of these insights into improved diagnostic and treatment approaches for NET-related pathologies.
Dr. Rachel Shukrun
Guest Editor
Manuscript Submission Information
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Keywords
- neutrophil extracellular traps (NETs)
- NETosis
- inflammation
- cancer microenvironment
- autoimmune disease
- thrombosis
- molecular signaling
- innate immunity
- biomarkers
- targeted therapy
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