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New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition
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New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 2707

Special Issue Editors

Dr. Yutang Wang

E-Mail Website
Guest Editor
Discipline of Life Science, Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3350, Australia
Interests: cardiovascular disease; hypertension; diabetes; atherosclerosis; abdominal aortic aneurysm; renal denervation; dyslipidemia; hyperuricemia
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dianna Magliano

E-Mail Website
Guest Editor
1. School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia
2. Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
Interests: diabetes; obesity; population health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue titled “New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition” (https://www.mdpi.com/journal/ijms/special_issues/08F9N38134).

Cardiovascular disease (CVD) is the leading cause of death worldwide, representing one-third of all global deaths. Comorbidities such as hypertension and diabetes significantly increase the risk of cardiovascular events and mortality. Breakthroughs in cardiovascular research and medicine have led to a decrease in cardiovascular morbidity and mortality. However, more research is needed to further understand the molecular mechanism of hypertension, diabetes, and CVD, which could eventually help reduce the burden of CVD. This Special Issue of IJMS will cover the latest developments in pathogenesis and the molecular mechanisms underlying hypertension, diabetes, and CVD (such as myocardial infarction and stroke), as well as molecular mechanisms underlying therapeutic and other types of treatments against CVD.

Dr. Yutang Wang
Prof. Dr. Dianna Magliano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • myocardial infarction
  • stroke
  • transient ischemic attack
  • hypertension
  • diabetes mellitus
  • atherosclerosis
  • inflammation

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Published Papers (3 papers)

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Research

17 pages, 4818 KB  
Article
Impact of PKC-MAPK Signaling on Cardiac Sympathetic Overactivation in Type-2 Diabetes Mellitus
by Jaswinder Singh, Afia Saabea Owusu Konadu, Yu Li, Boris Shabaltiy and Yu-Long Li
Int. J. Mol. Sci. 2026, 27(2), 723; https://doi.org/10.3390/ijms27020723 - 10 Jan 2026
Viewed by 629
Abstract
Type-2 Diabetes Mellitus (T2DM) is related to cardiac arrhythmias. The stellate ganglion (SG), part of the sympathetic nervous system, regulates heart function. Within the SG, satellite glial cells (SGCs) have gap junction channels (Cx43). Increased Cx43 permeability induces SGC depolarization and activates the [...] Read more.
Type-2 Diabetes Mellitus (T2DM) is related to cardiac arrhythmias. The stellate ganglion (SG), part of the sympathetic nervous system, regulates heart function. Within the SG, satellite glial cells (SGCs) have gap junction channels (Cx43). Increased Cx43 permeability induces SGC depolarization and activates the PKC-MAPK14-ADAM17 signaling pathway, releasing some endogenous factors that stimulate nearby cardiac postganglionic sympathetic neurons (CPSN). This study investigated the activation of the PKC-MAPK14-ADAM17 signaling pathway in T2DM SGs and SGCs as a novel mechanism of sympathetic overactivation. A total of 56 Sprague-Dawley rats were randomly assigned to sham and T2DM groups, and T2DM was induced using a high-fat diet combined with low-dose streptozotocin. Real-time RT-PCR, Western blot, and ELISA quantified mRNA/protein expression and enzymatic activity. The patch clamp technique assessed neuronal voltage-gated Ca2+ currents and action potentials, while electrophysiological recording measured cardiac sympathetic nerve activity (CSNA). T2DM rats exhibited marked upregulation of MAPK14, PKC-α, and ADAM17 mRNA/protein in the SG, alongside elevated enzymatic activities of PKC and ADAM17. T2DM also increased Ca2+ currents and neuronal excitability in the CPSN and induced the elevation of the CSNA. Upregulated PKC-MAPK-ADAM17 signaling in the SG might contribute to cardiac sympathetic overactivation in T2DM rats by enhancing the cell excitability of the CPSN. Full article
(This article belongs to the Special Issue New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition)
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24 pages, 1658 KB  
Article
Oral Toxicity Profile of a Novel Silk Lutein Extract and Assessment of Its Cardiovascular Benefits in Rodents
by Chainarong Tocharus and Manote Sutheerawattananonda
Int. J. Mol. Sci. 2026, 27(2), 577; https://doi.org/10.3390/ijms27020577 - 6 Jan 2026
Cited by 1 | Viewed by 588
Abstract
Silk Lutein (SL), a novel protein-bound lutein complex derived from Bombyx mori cocoons, offers an intriguing alternative to traditional sources. This study aimed to establish the complete toxicological profile of SL. Evaluations of the acute oral toxicity of SL (LD50 > 2000 [...] Read more.
Silk Lutein (SL), a novel protein-bound lutein complex derived from Bombyx mori cocoons, offers an intriguing alternative to traditional sources. This study aimed to establish the complete toxicological profile of SL. Evaluations of the acute oral toxicity of SL (LD50 > 2000 mg/kg body weight (BW)) were conducted in female Wistar rats and ICR mice. In the chronic toxicity trial, male and female Wistar rats were administered daily oral dosages of SL (5, 25, 50 mg/kg BW) for a duration of six months. The results indicated a robust safety profile for SL, with no treatment-related adverse effects detected. Apart from demonstrating its foundational safety, this study found that prolonged SL administration possessed significant, beneficial bioactive properties. Following four months of treatment, both male and female Wistar rats administered SL exhibited a significant hypotensive effect, maintaining their systolic blood pressure at approximately 120 mmHg and thereby averting the age-related hypertension observed in control subjects. Additionally, SL significantly reduced serum triglyceride levels in both sexes. The findings of this study confirm SL’s potential as a multipurpose nutraceutical by demonstrating that it is a safe constituent with a favorable toxicological profile and notable cardiovascular effects. Full article
(This article belongs to the Special Issue New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition)
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21 pages, 1027 KB  
Article
Consumption of Sericin Enhances the Bioavailability and Metabolic Efficacy of Chromium Picolinate in Rats
by Chainarong Tocharus, Jiraphan Saelim and Manote Sutheerawattananonda
Int. J. Mol. Sci. 2025, 26(23), 11505; https://doi.org/10.3390/ijms262311505 - 27 Nov 2025
Cited by 1 | Viewed by 863
Abstract
The effects of silk sericin (SS) supplementation on the functionality of chromium picolinate (CrPic) and lipid metabolism were assessed in male Sprague–Dawley rats to determine whether SS improves the bioavailability of CrPic and contributes to beneficial changes in lipid profiles and cardiovascular risk [...] Read more.
The effects of silk sericin (SS) supplementation on the functionality of chromium picolinate (CrPic) and lipid metabolism were assessed in male Sprague–Dawley rats to determine whether SS improves the bioavailability of CrPic and contributes to beneficial changes in lipid profiles and cardiovascular risk markers. Rats were administered different doses of SS (0, 1, 10, and 100 mg kg−1 body weight (BW)) in conjunction with CrPic (300 µg kg−1 BW) for 8 weeks through oral gavage. Body and organ weights, lipid profiles, glucose levels, chromium (Cr) accumulation, total protein, and adipocyte size were evaluated. Additionally, FTIR analysis was conducted to investigate the binding and release behavior of SS with CrPic. Although body weight and daily feed intake were comparable among groups, a significant increase in pancreas weight and reduction in omentum weight were observed across all CrPic-SS groups. Increased dosages of SS resulted in a significant reduction in triglyceride and plasma glucose levels. All CrPic and CrPic-SS treatments reduced LDL and total cholesterol while increasing HDL. Cr accumulation was elevated in the liver and kidneys of groups administered 10 and 100 mg kg−1 BW of SS, accompanied by a significant increase in total protein levels and a reduction in adipocyte size to less than 50 µm in all rats. FTIR analysis indicated that SS binds to CrPic at pH 2.0 and releases it at pH 7.0, demonstrating pH-dependent delivery similar to the gastrointestinal tract and possibly improved CrPic functionality. These findings indicate that SS improves the bioavailability of CrPic and positively affects lipid metabolism and cardiovascular risk markers in vivo. Full article
(This article belongs to the Special Issue New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition)
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