Neuromodulatory Effects of Serotonin, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 2144
Special Issue Editor
Interests: coronary artery disease; stent; noninvasive monitoring; nonlinear dynamics analysis; approximate entropy; 3D co-culture; glioblastoma; astrocytes; tumor microenvironment; PEGDA; addiction; cancer research; data science in medicine
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Special Issue Information
Dear Colleagues,
Serotonin in the central nervous system has been recognized as an important neurotransmitter and neuromodulator which regulates various physiological functions, such as pain sensation, cognition, and emotions like fear, anxiety, and depression. Serotonin implements many complex functions in the body through its widespread and diverse receptors.
Current research activities have found the association of chronic pain and anxiety with synaptic plasticity in the anterior cingulate cortex and the spinal cord. Serotonin shows the multiple modulatory effects of synaptic transmission and plasticity in those structures, including activation, inhibition, and biphasic actions.
GBM, or glioblastoma multiforme, is a brain tumor which is often associated with epileptic seizures. Recent research suggests that neurotransmitters and neuromodulators such as Serotonin, found in the tumor microenvironment, affect the excitability, proliferation, quiescence, and differentiation of neurons, glial cells, and neural stem cells, playing a significant role in various stages of GBMs.
This Special Issue aims to provide selected contributions on advances in the neuromodulatory effects of Serotonin.
Potential topics include, but are not limited to:
- Large-scale neuromodulation of Serotonin receptor networks.
- Effects of persistent inward currents on individual motor unit discharge patterns.
- Effects of Serotonin on retinal inputs in the thalamus.
- Control of complex adaptive dynamics in the brain.
- Chronic pain and injury-related anxiety.
- Peripheral nerve stimulation.
- Transcranial direct-current stimulation in major depressive disorder.
- Effects of serotonin on fear learning.
- Distribution of subcortical neuromodulatory afferents.
- Emotional memory processing during REM sleep.
- Role of Serotonin in Glioblastoma Multiforme (GBM).
Dr. Yasemin M. Akay
Guest Editor
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Keywords
- neuromodulation
- Serotonin
- pain research
- cognition
- emotions
- depression
- anxiety
- GBM
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