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Advanced Research in Veterinary Drugs
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Advanced Research in Veterinary Drugs

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 389

Special Issue Editor

Prof. Dr. Jianyong Li

E-Mail Website
Guest Editor
Key Laboratory of New Animal Drug of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Science of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
Interests: medicinal chemistry; drug mechanism; novel anti-inflammatory and antibacterial drugs; novel drug preparations; pharmacology; toxicology

Special Issue Information

Dear Colleagues,

Veterinary drugs not only play the role of preventing and treating animal diseases, but also have an important role in improving animal production performance, improving the quality of animal products, promoting feed conversion and utilization to improve feed returns, increasing the economic and social benefits of animal production, improving the environment, and maintaining ecological balance. Veterinary drugs are the fundamental guarantee for maintaining animal health and improving animal welfare. They are the basic force for preventing as wel as controlling zoonotic diseases and improving human health. Therefore, the research, development, and revaluation of veterinary drugs are persistent requirements in animal health.

This Special Issue will explore advanced research in veterinary drugs, including novel targets, structures, mechanisms in drug discovery, toxicity, pharmacodynamics, pharmacokinetics, residues, etc. By encompassing various experimental systems and promoting interdisciplinary research, we aim to highlight cutting-edge research and novel insights. Our aim is to provide a comprehensive understanding of veterinary drug mechanisms, their interactions with biological systems, and their potential therapeutic applications. We welcome submissions that explore the multifaceted roles of veterinary drugs, from molecular mechanisms to clinical applications, fostering collaboration among scientific disciplines to improve veterinary drug development and applications.

Prof. Dr. Jianyong Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary drug
  • target
  • chemical structure
  • mechanism
  • medicinal chemistry
  • toxicity
  • pharmacodynamics
  • pharmacokinetics
  • residues

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Published Papers (1 paper)

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Research

25 pages, 8721 KiB  
Article
Synthesis, Antimicrobial Activities, and Model of Action of Novel Tetralone Derivatives Containing Aminoguanidinium Moiety
by Qing-Jie Zhang, Yu-Xi Li, Wen-Bo Ge, Li-Xia Bai, Xiao Xu, Ya-Jun Yang, Xi-Wang Liu and Jian-Yong Li
Int. J. Mol. Sci. 2025, 26(13), 5980; https://doi.org/10.3390/ijms26135980 (registering DOI) - 21 Jun 2025
Abstract
The objectives of this study were to design, synthesize, and evaluate the antibacterial activity of a series of novel aminoguanidine-tetralone derivatives. Thirty-four new compounds were effectively synthesized through nucleophilic substitution reaction and guanidinylation reaction. Chemical structures of all the desired compounds were identified [...] Read more.
The objectives of this study were to design, synthesize, and evaluate the antibacterial activity of a series of novel aminoguanidine-tetralone derivatives. Thirty-four new compounds were effectively synthesized through nucleophilic substitution reaction and guanidinylation reaction. Chemical structures of all the desired compounds were identified by NMR and HR-MS spectroscopy. Most of the synthesized compounds showed significant antibacterial activity against ESKAPE pathogens and clinically resistant Staphylococcus aureus (S. aureus) isolates. S. aureus is an important pathogen that has the capacity to cause a variety of diseases, including skin infections, pneumonia, and sepsis. The most active compound, 2D, showed rapid bactericidal activity against S. aureus ATCC 29213 and MRSA-2 with MIC/MBC values of 0.5/4 µg/mL and 1/4 µg/mL, respectively. The hemolytic activity and cytotoxicity of 2D was low, with HC50 and IC50 (HEK 293-T) values of 50.65 µg/mL and 13.09 µg/mL, respectively. Compound 2D induced the depolarization of the bacterial membrane and disrupted bacterial membrane integrity, ultimately leading to death. Molecular docking revealed that dihydrofolate reductase (DHFR) may be a potential target for 2D. In the mouse skin abscess model caused by MRSA-2, 2D reduced the abscess volume, decreased bacterial load, and alleviated tissue pathological damage at doses of 5 and 10 mg/kg. Therefore, compound 2D may be a promising drug candidate for antibacterial purposes against S. aureus. Full article
(This article belongs to the Special Issue Advanced Research in Veterinary Drugs)
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