Pathophysiology and Molecular Mechanisms of Cardiovascular, Cardiometabolic, and Cardiorenal Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 11
Special Issue Editor
Interests: cardiology; cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, with their burden further amplified by metabolic disorders and chronic kidney disease (CKD). The interplay of cardiovascular, metabolic, and renal dysfunction defines the expanding spectrum of cardiometabolic and cardiorenal diseases, representing critical public health and socioeconomic challenges. Despite therapeutic progress, the molecular mechanisms linking metabolic dysregulation, renal impairment, and cardiovascular pathology remain incompletely understood, hindering the implementation of effective precision medicine. This Special Issue of the International Journal of Molecular Sciences aims to provide a comprehensive platform for cutting-edge research into the molecular and cellular pathways underlying cardiovascular, cardiometabolic, and cardiorenal diseases. Topics of interest include, but are not limited to, signaling mechanisms in vascular and myocardial remodeling, oxidative stress and redox biology, inflammation and immune regulation, genetic and epigenetic determinants, non-coding RNAs and transcriptomic regulation, mitochondrial function and energy metabolism, and novel biomarkers for early diagnosis and prognosis. Special emphasis will be placed on studies elucidating the molecular crosstalk between the heart, kidneys, and metabolic organs, as well as translational approaches bridging basic science with clinical outcomes. By gathering original research articles and state-of-the-art reviews, this Special Issue seeks to advance our understanding of the complex molecular networks underlying cardiovascular, cardiometabolic, and cardiorenal diseases and to foster innovative strategies for prevention, diagnosis, and therapy.
Prof. Dr. Carmine Savoia
Guest Editor
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Keywords
- heart failure
- cardiorenal syndrome
- oxidative stress
- inflammation
- endothelial dysfunction
- fibrosis and remodeling
- mitochondrial function and energy metabolism
- insulin resistance
- epigenetics and microRNAs
- biomarkers and precision medicine
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