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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Research on the Glioma and Tumor Microenvironment

edited by

Maria Beatrice Morelli

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4475 | Submission Open

Keywords: tumour microenvironment; immune cells; cell siganling; tumor niche; tumor heterogeneity; TMZ resistance; new therapeutic strategies; endothelial cells; fibroblasts; extracellular matrix

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidants: The Molecular Guardians Against Oxidative Stress

edited by

Karolina A. Wojtunik-Kulesza

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4406 | Submission Open

Keywords: antioxidant; free radical; oxidative stress; essential oils; secondary plant metabolites

(This special issue belongs to the Section Biochemistry)

MicroRNAs and Other Non-Coding RNAs as Regulators, Biomarkers, and Therapeutic Targets, 2nd Edition

edited by

Wan Lee

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4388 | Submission Open

Keywords: non-coding RNAs; microRNA; lncRNA; circRNA; piRNA; biomarker; therapeutic target

(This special issue belongs to the Section Molecular Biology)

The Roles of Phytochemicals and Antioxidants in Colon Cancers

edited by

Nunzio Antonio Cacciola

Francesca Borrelli

and

Paola De Cicco

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4324 | Submission Open

Keywords: colon cancer; colorectal cancer; natural products; drug-resistant; phytochemicals; antioxidants; cellular and molecular mechanisms; anti-cancer activity; prevention; treatments

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biological and Molecular Aspects of Exercise Adaptation

edited by

Alessandra Modesti

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4284 | Submission Open

Keywords: exercise; redox homeostasis; metabolic state; biological; physiological

(This special issue belongs to the Section Molecular Biology)

Advancing Regenerative Medicine: Basic Research and Translation in Clinics

edited by

Dragan Primorac

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4278 | Submission Open

Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Rifaat Safadi and Johnny Amer

submission deadline 20 Apr 2026 | 5 articles | Viewed by 4201 | Submission Open

Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut– liver axis; liver– spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4153 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Role of Mutations and Polymorphisms in Various Diseases: 2nd Edition

edited by

Anna Cieślińska

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4149 | Submission Open

Keywords: nutrigenomics; polymorphism; SNPs; mutations; predisposition; correlation; diversity; deletion; insertion

(This special issue belongs to the Section Molecular Genetics and Genomics)

Amyotrophic Lateral Sclerosis Behind Motor Neurons

edited by

Patrizia Longone

and Ezia Guatteo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4137 | Submission Open

Keywords: non-neuronal cells; neurotransmitters; systemic disease; motor system; neuronal circuitry; skeletal muscle metabolism; muscle oxidative metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Novel Insights into Bone Tissue: Pathologies and Therapeutic Strategies

edited by

Francesca Salamanna

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4126 | Submission Open

Keywords: bone tissue; pathologies; regenerative medicine; biomechanics; diagnostics; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4105 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

New Therapies, Pathogenetic and Inflammatory Mechanisms in Thrombosis

edited by

Matteo Becatti

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4068 | Submission Open

Keywords: thromboinflammation; endothelial dysfunction; antithrombotic therapies; oxidative stress; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antitumor Activity of Natural Products

edited by

Spiro Mihaylov Konstantinov

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4045 | Submission Open

Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights in the Mechanism of Obstetrical Complications: Prevention, Diagnosis, Monitoring, Treatment

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4021 | Submission Open

Keywords: high blood pressure; gestational diabetes; infections; preeclampsia; eclampsia; preterm labor; depresion; anxiety; pregnancy loss/miscarriage; stillbirth; premature membrane rupture; vaginal bleeding; placenta previa; anemia; intrauterine growth restriction; maternal risk factors; fetal risk factors; endothelial dysfunction; angiogenesis; oxidative stress; hormonal modifications; dyslipidemia; biochemical; genetic; epigenetic determinations; computational analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins

edited by

Eva Terzibasi Tozzini

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4003 | Submission Open

Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular and Physiological Responses of Insects to Biotic, Abiotic and Xenobiotic Constraints

edited by

Farman Ullah

Shuo Yan

and Yaobin Lu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4000 | Submission Open

Keywords: climatic changes; chemical insecticides; insect adaptation mechanisms; resistance mechanisms; ecosystem services; insect ecology; thermal stress adaptations

(This special issue belongs to the Section Molecular Biology)

Advances in Lung Inflammation, Injury, and Repair (Second Edition)

edited by

Andreas Schwingshackl

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3951 | Submission Open

Keywords: lung; inflammation; injury; repair; fibrosis; diagnostics; therapeutics; acute respiratory distress syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3940 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives

edited by Muhammad Y. Sheikh

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3922 | Submission Open

Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chitosan Materials: Recent Advances in Modification, Properties and Application

edited by

Gabriela Dudek

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3888 | Submission Open

Keywords: chitosan materials; biomedical applications; agriculture and food industry; water treatment and environmental applications; nanotechnology and advanced materials

(This special issue belongs to the Section Macromolecules)

Latest Review Papers in Molecular Immunology, 3rd Edition

edited by

Manlio Ferrarini

and

Vincenzo Barnaba

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3859 | Submission Open

Keywords: molecular immunology; review; immune cells

(This special issue belongs to the Section Molecular Immunology)

The Role of Long Non-Coding RNAs in Stress and Diseases

edited by

Antonis Giannakakis

and

Vladimir A. Kuznetsov

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3662 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); human health; core stress response; genotoxic stress; exosomes; biomarkers; stress-related diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright

edited by Jeff Abramson

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3626 | Submission Open

Keywords: membrane transporters; membrane protein; glucose transport; cell membrane; interface reaction

(This special issue belongs to the Section Molecular Biology)

Cyclodextrins: Properties and Applications, 3rd Edition

edited by

Miguel A. Esteso

and

Carmen M. Romero

submission deadline 20 Apr 2026 | 5 articles | Viewed by 3615 | Submission Open

Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties

(This special issue belongs to the Section Macromolecules)

Latest Advances in Cytokine Storm

edited by

Raymond Kaempfer

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3532 | Submission Open

Keywords: cytokine storm; cytokine release syndrome; inflammatory; protective immunity; multi-drug resistant bacterial strains

(This special issue belongs to the Section Molecular Immunology)

New Insights into Osteoclasts

edited by

David Gyori

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3524 | Submission Open

Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnosis and Treatments of Diabetes Mellitus: 2nd Edition

edited by

Mihail Virgil Boldeanu

submission deadline 20 Apr 2026 | 4 articles | Viewed by 3509 | Submission Open

Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Extracellular Vesicles in Immunology: Second Edition

edited by

Paolo Colombo

and Valeria Longo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3495 | Submission Open

Keywords: extracellular vesicles; exosomes; microvesicles; apoptotic bodies; cytokines; immunological response; immune system

(This special issue belongs to the Section Molecular Immunology)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

and

Vincenzo Piccolo

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3433 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Liver Disease and Hepatocellular Carcinoma—2nd Edition

edited by

Daniela Gabbia

and Sara Carpi

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3382 | Submission Open

Keywords: hepatocellular carcinoma; NAFLD/NASH; viral hepatitis; autoimmune liver disease; immunotherapy; biomarker

(This special issue belongs to the Section Molecular Oncology)

The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies

edited by Francesco Agostini

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3359 | Submission Open

Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3339 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds of Natural Origin: 2nd Edition

edited by

Katarzyna Pacyga

submission deadline 20 Apr 2026 | 5 articles | Viewed by 3338 | Submission Open

Keywords: plants; extraction methods; bioactive compounds; natural products; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Biomathematics, Computational Biology, and Bioengineering

edited by

Grzegorz Matyszczak

submission deadline 20 Apr 2026 | 5 articles | Viewed by 3321 | Submission Open

Keywords: biomathematics; machine learning; artificial intelligence; data science; systems biology; reaction– diffusion systems; nonlinear dynamics; bioreactors; biochemical reaction engineering

(This special issue belongs to the Section Molecular Informatics)

Molecular Breeding of Plants: From CRISPR/Cas9 to Transcriptomics and MABc

edited by

Kwon-Kyoo Kang

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3286 | Submission Open

Keywords: CRISPR/Cas9; transcriptomics; marker-assisted breeding; genome editing; plant genetics; gene expression; plant genomics; quantitative trait loci (QTL); crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Research on Mitochondrial Genetics and Epigenetics

edited by Arianna Montanari

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3261 | Submission Open

Keywords: mitochondrial DNA dynamics; retrograde regulation; epigenetic modulators; mitochondrial diseases; cellular homeostasis

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Skin Health and Disease

edited by

Mihaela Pertea

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3250 | Submission Open

Keywords: wound healing; molecular research in skin lesions; dermatologic surgery; cosmetic surgery; exosomes: new molecular targets of diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental and Reproductive Toxicology

edited by

Hyun-Jung Park

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3244 | Submission Open

Keywords: spermatogenesis; mouse models; reproduction biology; assisted reproductive technology; cell signaling; cellular biology; developmental biology

(This special issue belongs to the Section Molecular Biology)

Molecular Signatures in Autism Spectrum Disorders

edited by

Nikolay Mehterov

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3142 | Submission Open

Keywords: epigenetics; ncRNA; mRNA; cytokines; mitochondria; inflammation; autism

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Characterization and Applications of Nanomaterials in Nanomedicine and Cancer Therapy

edited by

Costica Caizer

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3113 | Submission Open

Keywords: nanomaterials (preparation methods; characterization techniques; properties); theoretical studies of nanomaterials and computational simulations; biocompatibility and biofunctionalization; applications in nanomedicine; applications in cancer therapy; drug delivery; nanoparticle imaging; magnetic resonance imaging (MRI); contrast agents; nanotheranostics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research on Neuroinflammation and Brain Aging

edited by

Stephen C. Bondy

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3105 | Submission Open

Keywords: neurotoxicology; aging; Alzheimer's disease; neurodegenerative diseases; inflammatory

(This special issue belongs to the Section Molecular Toxicology)

Sarcomas: From Molecular Insights to Personalized Therapies

edited by

Hye Jin You

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3020 | Submission Open

Keywords: soft tissue sarcoma; biomarkers; molecular mechanisms; experimental models; clinical factors associated with sarcoma development

(This special issue belongs to the Section Molecular Oncology)

Bone and Cartilage Injury and Repair: Molecular Aspects

edited by Silvia María Díaz-Prado

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3000 | Submission Open

Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

New Insights and Discoveries in the Pathogenesis, Diagnosis and Therapy of Neuromuscular Diseases

edited by

Dimitrios Kanakis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2996 | Submission Open

Keywords: neuromuscular diseases; autophagy; mitochondrial dysfunction; molecular genetics; blood-based biomarkers; antisense oligonucleotides; monoclonal antibodies

(This special issue belongs to the Section Molecular Neurobiology)

Fungal Pathogen-Host Interactions

edited by Patricia Albuquerque

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2992 | Submission Open

Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils

(This special issue belongs to the Section Molecular Microbiology)

Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches

edited by Francisco Giner

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2969 | Submission Open

Keywords: coeliac disease; microscopic colitis; Crohn’ s disease; ulcerative colitis; microbiota; biological therapies; refractory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiota’s Role in Respiratory Disorders and Diseases

edited by

Ioannis Alexandros Charitos

and Mauro Carone

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2936 | Submission Open

Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation

(This special issue belongs to the Section Molecular Microbiology)

Synthetic Chemistry in Drug Discovery

edited by Kathiravan Suppan

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2928 | Submission Open

Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis

(This special issue belongs to the Section Molecular Pharmacology)

Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential

edited by

Gregory Christodoulidis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2883 | Submission Open

Keywords: natural compounds; cancer research; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2701-2750 on page 55 of 70.

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