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Novel Insights into Bone Tissue: Pathologies and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 727

Special Issue Editor


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Guest Editor
Surgical Sciences and Technologies, IRCCS Instituto Ortopedizo Rizzoli, 40136 Bologna, Italy
Interests: biocompatibility; tissue engineering; stem cells and regenerative medicine; cell biology; advanced in vitro, ex vivo and in vivo models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone tissue, with its intricate physiology and susceptibility to a wide range of pathologies, remains a critical focus of scientific research. Understanding its mechanisms and disorders is essential for addressing global health challenges, as bone-related diseases, ranging from osteoporosis to rare genetic disorders, affect millions worldwide. This Special Issue highlights fundamental discoveries and clinical practice advancements, publishing high-quality, peer-reviewed articles that explore the molecular, cellular, and biomechanical aspects of bone health and disease. Topics of interest include the etiology and progression of bone disorders, innovative diagnostic tools, the interplay between bone and systemic conditions, and the development of cutting-edge therapeutic approaches, such as regenerative medicine, biomaterials, and pharmacological interventions. Researchers, clinicians, and interdisciplinary teams are invited to contribute original research, reviews, and case studies that advance the field, foster deeper understanding, and drive transformative clinical applications to improve patient outcomes globally.

Dr. Francesca Salamanna
Guest Editor

Manuscript Submission Information

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Keywords

  • bone tissue
  • pathologies
  • regenerative medicine
  • biomechanics
  • diagnostics
  • therapeutic strategies

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Published Papers (1 paper)

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Review

26 pages, 2031 KiB  
Review
Bone Defect Treatment in Regenerative Medicine: Exploring Natural and Synthetic Bone Substitutes
by Angelo Santoro, Andrea Voto, Luigi Fortino, Raffaella Guida, Carolina Laudisio, Mariarosaria Cillo and Anna Maria D’Ursi
Int. J. Mol. Sci. 2025, 26(7), 3085; https://doi.org/10.3390/ijms26073085 - 27 Mar 2025
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Abstract
In recent years, the management of bone defects in regenerative medicine and orthopedic surgery has been the subject of extensive research efforts. The complexity of fractures and bone loss arising from trauma, degenerative conditions, or congenital disorders necessitates innovative therapeutic strategies to promote [...] Read more.
In recent years, the management of bone defects in regenerative medicine and orthopedic surgery has been the subject of extensive research efforts. The complexity of fractures and bone loss arising from trauma, degenerative conditions, or congenital disorders necessitates innovative therapeutic strategies to promote effective healing. Although bone tissue exhibits an intrinsic regenerative capacity, extensive fractures and critical-sized defects can severely compromise this process, often requiring bone grafts or substitutes. Tissue engineering approaches within regenerative medicine have introduced novel possibilities for addressing nonunions and challenging bone defects refractory to conventional treatment methods. Key components in this field include stem cells, bioactive growth factors, and biocompatible scaffolds, with a strong focus on advancements in bone substitute materials. Both natural and synthetic substitutes present distinct characteristics and applications. Natural grafts—comprising autologous, allogeneic, and xenogeneic materials—offer biological advantages, while synthetic alternatives, including biodegradable and non-biodegradable biomaterials, provide structural versatility and reduced immunogenicity. This review provides a comprehensive analysis of the diverse bone grafting alternatives utilized in orthopedic surgery, emphasizing recent advancements and persistent challenges. By exploring both natural and synthetic bone substitutes, this work offers an in-depth examination of cutting-edge solutions, fostering further research and innovation in the treatment of complex bone defects. Full article
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