New Therapies, Pathogenetic and Inflammatory Mechanisms in Thrombosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 31
Special Issue Editor
Interests: thrombosis; fibrinogen; oxidative stress; protein structure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Thrombosis remains a major global health challenge, contributing to life-threatening conditions such as myocardial infarction, ischemic stroke, and venous thromboembolism. While anticoagulant and antiplatelet therapies have significantly improved patient outcomes, the intricate interplay between coagulation, inflammation, and endothelial dysfunction continues to pose challenges in both prevention and treatment.
This Special Issue aims to explore the latest advances in thrombosis research, focusing on the molecular mechanisms underlying thrombus formation and resolution, as well as novel therapeutic strategies that target its pathogenetic and inflammatory components. I invite contributions that address key aspects of thrombosis, including:
- Molecular and cellular mechanisms of thrombosis, with emphasis on platelet activation, endothelial dysfunction, and immune-thrombotic interactions.
- The role of oxidative stress, cytokines, and inflammatory pathways in thrombogenesis and thromboinflammation.
- Next-generation anticoagulant and antiplatelet therapies, including targeted approaches to minimize bleeding risks.
- Personalized medicine and biomarker-driven approaches in thrombosis prevention and treatment.
- Metabolic disorders (diabetes, obesity, dyslipidemia) and their impact on thrombotic risk, with potential therapeutic implications.
- Artificial intelligence (AI) and computational models in thrombosis research, including predictive analytics for risk assessment and drug discovery.
- Microbiota-thrombosis interactions, exploring the influence of gut dysbiosis and systemic inflammation.
- Nanotechnology-based drug delivery systems and innovative therapeutic strategies for improved thromboprophylaxis.
- Clinical and translational research on thromboinflammation and novel treatment paradigms.
By gathering cutting-edge research in these areas, this Special Issue aims to bridge the gap between fundamental science and clinical applications, fostering a deeper understanding of thrombotic disorders and paving the way for innovative therapeutic interventions.
I look forward to your valuable contributions to this Special Issue and to advancing research that may improve the prevention and treatment of thrombotic diseases.
Dr. Matteo Becatti
Guest Editor
Manuscript Submission Information
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Keywords
- thromboinflammation
- endothelial dysfunction
- antithrombotic therapies
- oxidative stress
- thrombosis
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