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The Roles of Phytochemicals and Antioxidants in Colon Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 947

Special Issue Editors


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Guest Editor
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: polyphenol-rich extract; colorectal carcinogenesis; cannabinoids; apoptosis

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Guest Editor
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: phytotherapy; natural products; skin cancer; inflammatory bowel diseases
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Special Issue Information

Dear Colleagues,

Colon Cancer (CRC) is one of the leading causes of death worldwide. The ineffectiveness of current treatment methods is reflected in the frequent relapses and the emergence of a drug-resistant form of CRC. Numerous scientific studies have shown the great potential of natural products as a source of anti-CRC agents with novel functions.

With this Special Issue, we aim to provide a comprehensive understanding of phytochemicals and antioxidants with anti-CRC activity in various in vitro and in vivo models, particularly the underlying cellular and molecular mechanisms of action of these compounds. We invite the submission of short communications, original articles and reviews that shed light on the history of bioactive dietary compounds and expand our current knowledge on the future treatment and prevention of colorectal cancers.

Dr. Nunzio Antonio Cacciola
Prof. Dr. Francesca Borrelli
Dr. Paola De Cicco
Guest Editors

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Keywords

  • colon cancer
  • colorectal cancer
  • natural products
  • drug-resistant
  • phytochemicals
  • antioxidants
  • cellular and molecular mechanisms
  • anti-cancer activity
  • prevention
  • treatments

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Published Papers (1 paper)

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Research

18 pages, 2900 KiB  
Article
Smilax glabra Flavonoids Inhibit AMPK Activation and Induce Ferroptosis in Obesity-Associated Colorectal Cancer
by Jianqin Xu, Zhaowei Cai, Ziyao Pang, Jiayan Chen, Keyan Zhu, Dejun Wang and Jue Tu
Int. J. Mol. Sci. 2025, 26(6), 2476; https://doi.org/10.3390/ijms26062476 - 10 Mar 2025
Viewed by 582
Abstract
Smilax glabra flavonoids (SGF), the active components of Smilax glabra Roxb., have been demonstrated to exhibit antioxidant activity and metabolic benefits in obesity, leading us to further explore their antitumor effects in obesity-related colorectal cancer (CRC). This study investigated the antiproliferative effects of [...] Read more.
Smilax glabra flavonoids (SGF), the active components of Smilax glabra Roxb., have been demonstrated to exhibit antioxidant activity and metabolic benefits in obesity, leading us to further explore their antitumor effects in obesity-related colorectal cancer (CRC). This study investigated the antiproliferative effects of SGF on obesity-related CRC by using a murine colon adenocarcinoma MC38 cell line. The underlying mechanisms were further explored via RNA-Seq and bioinformatics analysis in combination with experimental validation. SGF was proven to possess cytotoxic effects against MC38 cells, indicated by the inhibition of proliferation and migration, especially in an adipocyte-rich environment. In line with this, SGF exhibited much stronger antiproliferative effects on MC38-transplanted tumors in obese mice. Transcriptomics analysis showed that the cytotoxic effects of SGF might be related to the AMPK pathway and ferroptosis. On this basis, SGF was confirmed to induce ferroptosis and dictate ferroptosis sensitivity in a high-fat context mimicked by a two-step conditioned medium (CM) transfer experiment or a Transwell coculture system. The results of Western blotting validated that SGF suppressed the phosphorylation of AMPK, accompanied by alterations in the biomarkers of ferroptosis. These results demonstrate that SGF exerts in vitro and in vivo antiproliferative effects in obesity-associated CRC through inhibiting AMPK activation, thereby driving ferroptosis. Full article
(This article belongs to the Special Issue The Roles of Phytochemicals and Antioxidants in Colon Cancers)
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