Molecular Research on Endothelial Cell Injury and Repair
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 691
Special Issue Editors
Interests: hematologic malignancies; thrombosis; complement; cellular therapy; lymphoma; myeloma; COVID-19
Special Issues, Collections and Topics in MDPI journals
Interests: vascular pathology; endothelial dysfunction; hypertension; cardiovascular diseases; chronic inflammation; autoimmune rheumatic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endothelial cells play a pivotal role in vascular homeostasis and fluid balance though a continuous “cross-talk” between the circulation and the surrounding tissues. Endothelial cell injury disturbs endothelial junctions, dysregulates vascular function and damages the homeostatic balance. The regulatory mechanisms responsible for endothelial regeneration and vascular repair are then potentiated, but they are not always effective in restoring the function of the endothelial barrier, regenerating a functional endothelium and reversing vascular damage. As a result, endothelial injury triggers several pathophysiological pathways, eventually resulting in the establishment of a continuously expanding list of diverse clinical diseases.
Despite recent advances, a comprehensive understanding of the molecular mechanisms and signaling pathways that are responsible for endothelial injury and the regulatory mechanisms that mediate endothelial repair and vascular regeneration is lacking. This would facilitate the development of innovative treatment strategies for a wide range of systemic diseases. This Special Issue therefore welcomes the submission of articles that present new concepts and knowledge, including insights into endothelial cell injury and repair. The scope of this Special Issue includes, but is not limited to, the following topics:
- Cardiovascular diseases;
- Hematological disorders including hematopoietic cell transplantation;
- Chronic inflammatory disorders including autoimmune rheumatic diseases;
- Sepsis and acute respiratory distress syndrome;
- Novel entities recognized as endotheliopathies, such as COVID-19.
Dr. Eleni Gavriilaki
Dr. Panagiota Anyfanti
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- endothelial injury
- endothelial repair
- endotheliopathies
- endothelial dysfunction
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