Synthetic Chemistry in Drug Discovery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 1030
Special Issue Editor
Interests: drug derivatization; catalysis; electrochemistry; AI-driven molecular design; late-stage functionalization of drugs
Special Issue Information
Dear Colleagues,
This Special Issue highlights the pivotal role of synthetic chemistry in advancing drug discovery, focusing on the design, synthesis, and optimization of novel molecular entities with therapeutic potential. At the molecular level, synthetic chemistry enables the construction of complex drug-like molecules, the exploration of structure–activity relationships (SARs), and the development of innovative synthetic methodologies to address unmet medical needs. Contributions are encouraged to cover diverse areas, including the synthesis of bioactive compounds, fragment-based drug design, late-stage functionalization, and the application of cutting-edge technologies, such as automated synthesis and AI-driven molecular design. This Special Issue aims to showcase how synthetic chemistry drives the discovery of new drug candidates, enhances drug efficacy, and overcomes challenges in bioavailability, selectivity, and toxicity. By bridging chemical innovation with biological relevance, this Special Issue seeks to inspire interdisciplinary collaborations and accelerate the development of next-generation therapeutics.
Dr. Kathiravan Suppan
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- late-stage functionalization
- AI-driven synthesis
- drug discovery
- synthetic chemistry
- transition metal catalysis
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