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Advancing Regenerative Medicine: Basic Research and Translation in Clinics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1260

Special Issue Editor


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Guest Editor
1. Eberly College of Science, Penn State University, 517 Thomas St, State Coll, PA 16803, USA
2. St. Catherine Hospital, Universities of Split, Osijek and Rijeka, 49210 Zabok, Croatia
Interests: personalised medicine; stem cells; pharmacogenetics; paediatrics; DNA analysis; human diseases; bone diseases; forensic genetics; population genetics
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Special Issue Information

Dear Colleagues,

The development of regenerative medicine, based on restoring, replacing, or reconstructing damaged tissue, is challenging the current treatment paradigm. Regenerative medicine, which includes cell-based therapy and synthetic biology approaches to treat various diseases, holds significant promise but may need further development.

Several key segments are associated with regenerative medicine: blood-based therapies (platelet-rich plasma), stem cell therapy, biomaterials, and tissue engineering. AI and 3D bioprinting are revolutionizing regenerative medicine, while next-generation sequencing and other multi-OMICS technologies are helping us understand stem cell biology better, which will eventually play an important role in developing new directions in stem cell research and treatment. However, ethical considerations, particularly in stem cell research and therapy, remain of great importance.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Emerging Issues in Stem Cell Research and Regenerative Medicine;
  • Best Practices in Regenerative Medicine;
  • Tissue Engineering and Biomaterials in Regenerative Medicine;
  • Exosomal Therapy—A New Frontier in Regenerative Medicine;
  • Orthobiologics and Regenerative Medicine;
  • Clinical Trials in Regenerative Medicine.

We look forward to receiving your contributions.

Prof. Dr. Dragan Primorac
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • regenerative medicine
  • stem cells
  • tissue engineering
  • exosomes
  • orthobiologics

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Published Papers (1 paper)

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Review

24 pages, 1321 KiB  
Review
Therapeutic Potential and Mechanisms of Mesenchymal Stem Cells in Coronary Artery Disease: Narrative Review
by Tejas Patel, Jana Mešić, Shai Meretzki, Tomer Bronshtein, Petar Brlek, Vered Kivity, Samir B. Pancholy, Matko Petrović and Dragan Primorac
Int. J. Mol. Sci. 2025, 26(11), 5414; https://doi.org/10.3390/ijms26115414 - 5 Jun 2025
Viewed by 1085
Abstract
Coronary artery disease (CAD) remains a leading cause of global morbidity and mortality despite advances in medical and interventional therapies. Mesenchymal stem cell (MSC) therapy has emerged as a promising regenerative approach for patients with refractory or non-revascularizable CAD. MSCs exhibit unique immunomodulatory, [...] Read more.
Coronary artery disease (CAD) remains a leading cause of global morbidity and mortality despite advances in medical and interventional therapies. Mesenchymal stem cell (MSC) therapy has emerged as a promising regenerative approach for patients with refractory or non-revascularizable CAD. MSCs exhibit unique immunomodulatory, pro-angiogenic, and anti-fibrotic properties, primarily through paracrine mechanisms involving the secretion of cytokines, growth factors, and exosomal microRNAs. Clinical and preclinical studies have demonstrated improvements in myocardial perfusion, left ventricular ejection fraction (LVEF), and functional capacity following MSC-based interventions, particularly in patients with low baseline LVEF and heightened inflammation. Various MSC sources—including bone marrow, adipose tissue, and umbilical cord—offer distinct advantages, while delivery strategies such as intracoronary, intramyocardial, intravenous, and subcutaneous administration impact cell retention and efficacy. Advances in genetic modification, hypoxic preconditioning, and exosome-based therapies aim to enhance MSC survival and therapeutic potency. However, challenges persist regarding cell engraftment, cryopreservation effects, and inter-patient variability. Moving toward precision cell therapy, future approaches may involve stratifying patients by inflammatory status, ischemic burden, and comorbidities to optimize treatment outcomes. MSCs may not yet replace conventional therapies but are increasingly positioned to complement them within a personalized, regenerative framework for CAD management. Full article
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