Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 86
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents the leading cause of chronic liver disease worldwide and is a growing contributor to extrahepatic complications, including cardiovascular disease and hepatocellular carcinoma. Despite advances in epidemiology and clinical stratification, substantial gaps remain in the mechanistic understanding and molecular targeting of MASLD. This Special Issue seeks to showcase innovative research that elucidates the molecular drivers of MASLD initiation and progression—ranging from hepatocellular lipotoxicity, insulin resistance, and mitochondrial dysfunction to gut–liver axis signaling and inflammatory cascades.
We welcome original research and reviews spanning basic, translational, and early-stage clinical studies. Submissions utilizing molecular approaches in preclinical models, patient biospecimens, or integrated omics platforms are particularly encouraged. In addition, the Special Issue will highlight studies that translate molecular findings into diagnostic biomarkers, therapeutic targets, and risk stratification tools. Our aim is to bring together cutting-edge mechanistic insights and clinically relevant innovation to advance the early detection, personalized management, and prevention of MASLD and its complications.
Dr. Rifaat Safadi
Guest Editor
Manuscript Submission Information
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Keywords
- MASLD (metabolic dysfunction-associated steatotic liver disease)
- lipotoxicity
- inflammation
- mitochondrial dysfunction
- gut–liver axis
- liver–spleen axis
- fibrosis biomarkers
- translational hepatology
- precision liver medicine
- insulin resistance
- molecular therapeutics
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