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Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches

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Guest Editor
Department of Pathology, University Hospital “La Fe”, 46009 Valencia, Spain
Interests: soft tissue and bone tumors; colon cancer; inflammatory bowel disease
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Special Issue Information

Dear Colleagues,

Inflammatory bowel diseases (IBDs) include Crohn’s disease (CD), ulcerative colitis (UC), coeliac disease, and microscopic colitis, among others. They are chronic immune-mediated conditions, characterized by the recurrent inflammation of the gastrointestinal tract. IBDs affect more than 10 million people worldwide, and different genders are equally affected. It has been shown that patients with IBDs are at an increased risk of colorectal cancer (CRC) and CRC‐related mortality. The intestinal microbiota has been studied as a possible etiology of the disease, but this relationship is not yet clear. Moreover, over the last two decades, biological therapies have revolutionized the treatment of IBDs, although some patients continue to show resistance to medical treatment and require surgical treatment, increasing morbidity. Consequently, more pathological and molecular studies are necessary to improve diagnosis, predicting relapses, prognosis, and therapies in people with IBDs. We are launching this Special Issue with this purpose, hoping that it will be useful for patients, pathologists, and researchers.

Dr. Francisco Giner
Guest Editor

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Keywords

  • coeliac disease
  • microscopic colitis
  • Crohn’s disease
  • ulcerative colitis
  • microbiota
  • biological therapies
  • refractory disease

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Published Papers (1 paper)

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Review

18 pages, 1199 KiB  
Review
Molecular Basis of Chronic Intestinal Wall Fibrosis in Inflammatory Bowel Diseases
by Patrycja Sputa-Grzegrzolka, Anna Socha-Banasiak, Piotr Dziegiel and Bartosz Kempisty
Int. J. Mol. Sci. 2025, 26(12), 5754; https://doi.org/10.3390/ijms26125754 - 16 Jun 2025
Viewed by 163
Abstract
Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), are chronic inflammatory disorders of the gastrointestinal tract. Chronic inflammation in the course of IBD is an important initiating factor of fibrosis of the intestinal wall. Intestinal fibrosis is [...] Read more.
Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), are chronic inflammatory disorders of the gastrointestinal tract. Chronic inflammation in the course of IBD is an important initiating factor of fibrosis of the intestinal wall. Intestinal fibrosis is one of the most common and important complications of IBD and, due to the irreversibility of the process and the need for surgical treatment, currently poses a major clinical challenge. In this review, we presented in detail the process of intestinal wall fibrosis at the molecular, immunological, and clinical levels. We characterized the mediators, including transforming growth factor β (TGF-β), tumor necrosis factor-α (TNF-α), and others participating in this process. We also described the type 2 epithelial–mesenchymal transition (EMT) process closely associated with chronic inflammation, leading to excessive development of connective tissue in the intestinal wall in the course of IBD. Full article
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